(Isocyanoimino)triphenylphosphorane
Grundinformationen
- CAS
73789-56-7- Standard-SMILES
[C-]#[N+]N=P(c1ccccc1)(c1ccccc1)c1ccccc1- InChIKey
NIDTXBFHPXMXTR-UHFFFAOYSA-N- Summenformel
- C19H15N2P
- Durchschnittliche Molmasse
- 302,3 g/mol
- Monoisotopische Masse
- 302,09728549
Namen und Bezeichner
- Bevorzugter Name
- (Isocyanoimino)triphenylphosphorane
- IUPAC
- isocyanoimino(triphenyl)-λ5-phosphane
- Englischer Name
- (Isocyanoimino)triphenylphosphorane
- Summenformel
- C19H15N2P
- Molmasse
- 302.309561
Namen und Synonyme
(Isocyanoimino)triphenylphosphoraneDTXSID10460651RefChem:406557DTXCID00411470678-573-773789-56-7isocyanoimino(triphenyl)-lambda5-phosphaneMFCD09038528SCHEMBL989571NSC371099AKOS025295682NSC-371099
Weitere Namen anzeigen
(N-Isocyanoi(N-Isocyanoimino)Triphenylphosphorane(Isocyanoimino)triphenylphosphorane>(N-Isocyanoimino)triphenylphosphorane 95%(N-Isocyanoimino)triphenylphosphorane1-methylidyne-2-(triphenyl-lambda~5~-phosphanylidene)diazanium1-methylidyne-2-(triphenyl-lambda~5~-phosphanylidene)diazani...
I0643T72892ISOCYANO(TRIPHENYL-??-PHOSPHANYLIDENE)AMINEisocyanoiminotriphenylphosphoraneisocyano(triphenyl-N-isocyaniminotriphenC19H15N2PN-isocyaniminotriphenylphosphorane
Datenbank-Bezeichner
- CAS
73789-56-7- PubChem CID
- 11266621
- DTXSID
DTXSID10460651- EC Number
- 678-573-7
- Nikkaji
- J1.078.415H、J1.296.091C
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 5
- Polarare Oberfläche (TPSA)
- 16,7 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 22
- Formalladung
- 0
- Komplexität
- 391
Physikochemische Eigenschaften
- Schmelzpunkt
- 160 · 160-161 °C
- storage temp.
- 2 · under inert gas (nitrogen or Argon) at 2-8°C
- Aggregatzustand
- solid
- Farbe
- White to Light yellow to Light orange
- Major Application
- peptide synthesis
- InChI
- 1S/C19H15N2P/c1-20-21-22(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19/h2-16H
- InChIKey
- NIDTXBFHPXMXTR-UHFFFAOYSA-N
- SMILES
- [P](=N[N+]#[C-])(c3ccccc3)(c2ccccc2)c1ccccc1
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302+H312+H332 (20%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 5 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (40%)
Sicherheitsdaten
- wgk
- WGK 3
- hs_code
- 29319090
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2STOT SE 3
Chemie und Industrie
Anwendungen
VerwendenDespite growing interest for therapeutic and other biological applications, cyclic peptidomimetics are challenging to synthesize. As reported by the lab of Andrei Yudin, (N-isocyanoimino)triphenylphosphorane (Pinc) enables zwitterionic-controlled generation of peptide macrocyles from linear peptides and aldehydes. Containing a 1,3,4-oxadiazole, the resulting peptide exhibits both improved membrane permeability, lipophilicity, and aqueous solubility.Different functional groups can be introduced by varying the aldehyde, and initial work used propionaldehyde (538124), phenylacetaldehyde (107395), and isovaleraldehyde (146455).
Vor- und nachgelagerte Produkte
Nachgelagerte Produkte
Zugehörige Reaktionen
7
Notizen zur Verbindung
Wird geladen…