Grundinformationen
- CAS
82-88-2- Standard-SMILES
CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12- InChIKey
ISFHAYSTHMVOJR-UHFFFAOYSA-N- Summenformel
- C19H19N
- Durchschnittliche Molmasse
- 261,4 g/mol
- Monoisotopische Masse
- 261,15174961
Überblick
Phenindamine is an indene.
Namen und Bezeichner
- Bevorzugter Name
- Phenindamine
- IUPAC
- 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine
- Lokaler Name
- 2,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno(2,1-c)pyridin
- Englischer Name
- phenindamine
- Summenformel
- C19H19N
- Molmasse
- 261.36
Namen und Synonyme
PhenindamineThephorin82-88-2FenindaminaPhenindaminum772BQ8KSSTNU-15042,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno(2,1-c)pyridine1H-Indeno(2,1-c)pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-DTXSID00234521H-Indeno[2,1-c]pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-2,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno[2,1-c]pyridine
Weitere Namen anzeigen
phenindamine USP/EP/BPPhenindamine Hydrogen Tartrate2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine1H-Indeno2,1-cpyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-
2-METHYL-9-PHENYL-1H,2H,3H,4H,9H-INDENO[2,1-C]PYRIDINE2-methyl-9-phenyl-1H,2H,3H,4H,9H-indeno(2,1-c)pyridineRefChem:172693DTXCID403452R06AX042,3,4,9-tetrahydro-2-methyl-9-phenyl-lH-indeno-(2,1-c)pyridine201-443-4Fenindamina [INN-Spanish]
Datenbank-Bezeichner
- CAS
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 3,1
- Polarare Oberfläche (TPSA)
- 3,2 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 1
- Frei drehbare Bindungen
- 1
- Schwere Atome
- 20
- Formalladung
- 0
- Komplexität
- 391
Experimentelle und physikochemische Eigenschaften
Solubility2.77e-02 g/L
Human Drugs
Breast Feeding; Lactation; Milk, Human; Antihistamines
Pharmaceuticals
Melting Point91 °C
Physical DescriptionSolid
Physikochemische Eigenschaften
- Schmelzpunkt
- 90 · 90-91°
- Dichte
- 1.17 · 1.17
- pka
- 8.11 · pKa 8.11±0.08(H2O,t undefined,I=0.30(NaCl)) (Uncertain)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Gefahrenhinweise
Regulatory Information1H-Indeno2,1-cpyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-: Does not have an individual approval but may be used under an appropriate group standard
Toxikologische Informationen
Toxicity Summary
Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
Signs and SymptomsSymptoms of a phenindamine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Chemie und Industrie
Pharmakologische Informationen
ATC Code
R - Respiratory system
QR - Respiratory system
Pharmacodynamics
Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Allergies are caused by an excessive type 1 hypersensitivity response of the body to allergens, mediated by inappropriate histamine signalling. By inhibiting the binding of histamine, antihistamines decrease the normal histamine response from cells, consequently decreasing allergic symptoms.
Mechanism of Action
Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
MeSH Pharmacological Classification
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Cellular LocationsMembrane
Metabolite PathwaysPhenindamine H1-Antihistamine Action
Verwendung und Herstellung
UsesUsed to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold.
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