| GHS-Einstufung | DangerH304 (44.5%): May be fatal if swallowed and enters airways [Danger Aspiration hazard]H315 (54.7%): Causes skin irritation [Warning Skin corrosion/irritation]H373 (44.5%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]H413 (97%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]P260, P264, P273, P280, P301+P316, P302+P352, P319, P321, P331, P332+P317, P362+P364, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 236 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.H413 (100%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] |
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| Regulatorische Informationen | Chemical: Benzene, bis(1-methylethyl)-Benzene, 1,2-bis(1-methylethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Benzene, 1,2-bis(1-methylethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Cease Manufacture Update: 23-05-2013 https://echa.europa.eu/registration-dossier/-/registered-dossier/13543 |
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| Brandgefahren | Combustible. Above 77 °C explosive vapour/air mixtures may be formed. |
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| Brandpotenzial | Moderate, when exposed to heat or flame. |
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| Gefahrenübersicht | Inhalation of high concentrations can cause CNS depression[ICSC] An eye, mucous membrane, and upper respiratory tract irritantMay cause CNS depressionDefats the skin[CAMEO] May cause mild to moderate irritation, based on animal studies[CHEMINFO]A skin, eye, and respiratory tract irritantMay be harmful after ingestion, inhalation, or skin contactAnesthetic effect at high doses[MSDSonline] |
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| UN-Einstufung | UN Hazard Class: 9UN Pack Group: III |
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| DOT Emergency Guidelines | /GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Isopropylbenzene//GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Isopropylbenzene//GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Isopropylbenzene//GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. /Isopropylbenzene/For more DOT Emergency Guidelines (Complete) data for 1,2-DIISOPROPYLBENZENE (8 total), please visit the HSDB record page. |
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| Hazard Classes and Categories | Aquatic Chronic 4 (100%)Asp. Tox. 1 (44.5%)Skin Irrit. 2 (54.7%)STOT RE 2 (44.5%)Aquatic Chronic 4 (97%)Flammable liquids - Category 4Specific target organ toxicity - Repeated exposure - Category 2 (nervous system, liver)Hazardous to the aquatic environment (Acute) - Category 1Hazardous to the aquatic environment (Long-term) - Category 1 |
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| Hazardous Reactivities and Incompatibilities | ... Can react with oxidizing materials. |
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| Brandbekämpfung | Use powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
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| Erste-Hilfe-Maßnahmen | Fresh air, rest.Rinse and then wash skin with water and soap.Rinse with plenty of water (remove contact lenses if easily possible).Rinse mouth. Rest. |
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| Sichere Lagerung | Provision to contain effluent from fire extinguishing. Keep in a well-ventilated room. Store in an area without drain or sewer access. |
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| Brandbekämpfungsverfahren | Foam, carbon dioxide, dry chemical, water spray or mist. |
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| Verschüttetes entsorgen | Remove all ignition sources. Do NOT let this chemical enter the environment. Ventilation. Collect leaking liquid in covered containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. |
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| Eye Prevention | Wear safety spectacles. |
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| Fire Prevention | NO open flames. Above 77 °C use a closed system and ventilation. |
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| Inhalation Risk | No indication can be given about the rate at which a harmful concentration of this substance in the air is reached. |
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| Skin Prevention | Protective gloves. |
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| Exposure Prevention | PREVENT GENERATION OF MISTS! |
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| Ingestion Prevention | Do not eat, drink, or smoke during work. |
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| Inhalation Prevention | Use ventilation. |
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| Umweltverhalten | TERRESTRIAL FATE: Based upon an estimated Koc value of 4000(1), diisopropylbenzene is expected to be relatively immobile in soil(SRC). Insufficient data are available to predict the rates or importance of soil degradation processes(SRC).AQUATIC FATE: Volatilization and adsorption to sediment may be important transport processes in water for diisopropylbenzene. Volatilization half-lives of 3.8 and 45 hours can be estimated for a model river (1 meter deep) and model pond (2 meters deep), respectively, when the effects of adsorption are not present(1-2)in the presence of adsorption (Koc of 4000), the volatilization half-life from the pond increases to 27 days(2). Based upon an estimated Koc of 4000(3), diisopropylbenzene may partition from the water column to sediment and suspended material. Insufficient data are available to predict the importance of biodegradation(SRC).ATMOSPHERIC FATE: Based upon vapor pressures of 0.25 to 0.39 mm Hg at 25 °C(1), the diisopropylbenzene isomers are expected to exist almost entirely in the vapor-phase in the ambient atmosphere(2). Diisopropylbenzene will degrade in an average ambient atmosphere by reaction with photochemically produced hydroxyl radicals (estimated half-life of 30 hours)(3,SRC). |
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| Unerwünschte Wirkungen | Neurotoxin - Acute solvent syndrome |
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| Signs and Symptoms | Headache. Drowsiness. |
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| Effluent Concentrations | m- and p-Diisopropylbenzene were qualitatively detected in water samples collected from advanced waste treatment facilities in Pomona, CA (Jun 17, 1975) and Lake Tahoe, CA (Oct 24, 1974)(1). Diisopropylbenzene was detected in the wastewater effluent from a chemical manufacturing facility in LA (concn, site or date not reported)(2). |
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| ICSC Environmental Data | The substance is very toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment. |
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| Soil Adsorption/Mobility | Using a structure estimation method based on molecular connectivity indexes, the Koc for diisopropylbenzene can be estimated to be about 4000(1). This estimated Koc indicates that diisopropylbenzene will be relatively immobile in soil(2,SRC). |
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| Natural Pollution Sources | Diisopropylbenzene is reported to occur in coal(1). |
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| Artificial Pollution Sources | Diisopropylbenzene occurs in large amounts in the high-boiling fractions of cumene production facilities(1) and can therefore be released in waste streams and fugitive emissions associated with cumene production. Distillate fractions containing diisopropylbenzene can be blended into gasoline, diesel and other hydrocarbon fuels(2)therefore, evaporation or incomplete combustion of these fuels can release diisopropylbenzene into the atmosphere. Diisopropylbenzene and its individual isomers are used in solvents and as feedstock for making other chemicals(1-3) which can result in their release to the environment through evaporation and manufacturing waste streams(SRC). |
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| Environmental Bioconcentration | The log BCF (bioconcentration factor) of the o- and m-isomers of diisopropylbenzene was experimentally measured to be 2.11-2.14(1) in goldfish. This suggests that some bioconcentration may occur in aquatic organisms(SRC). |
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| Volatilization from Water/Soil | The Henry's Law constant for diisopropylbenzene can be estimated(SRC) to be 0.0204 atm-cu m/mole using a structure estimation method(1). This value of Henry's Law constant indicates rapid volatilization from water(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep flowing 1 m/sec with a wind velocity of 3 m/sec) can be estimated(SRC) to be about 3.8 hours(2). The volatilization half-life from a model environmental pond can be estimated to be about 45 hours if the effect of adsorption to sediment is ignored(3)if the effect of adsorption to sediment is predicted from an estimated Koc of 4000(4), the estimated volatilization half-life from the pond increases to about 27 days(3,SRC). |
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| Non-Human Toxicity Excerpts | Rated 1 on rabbit eyes. /On a scale of 1 to 10 with 10 being the most severe./Diisopropylbenzene occurs in three isomeric forms, namely as the ortho, the meta, and the para derivatives ... . Orally, they are of very low toxicity. Of 10 rats dosed with 5.0 ml/kg, no deaths for the meta, and one death for the ortho and the para isomers occurred. ... Rats and rabbits exposed to 0.2 to 1.0 mg/l (30 to 150 ppm) for 90 minutes daily for 5 weeks developed vascular hyperemia, hemorrhaging in most major organs, and fatty and protein dystrophy in the liver, kidney, and heart, and hyperplasia of the bone marrow.Diisopropylbenzene rated 1 on rabbit eyes /on a scale of 1 to 10 with 10 being the most severe/. /Diisopropylbenzene/Diisopropylbenzene occurs in three isomeric forms, namely as the ortho, the meta, and the para derivatives ... . Orally, they are of very low toxicity. Of 10 rats dosed with 5.0 ml/kg, no deaths for the meta, and one death for the ortho and the para isomers occurred. ... Rats and rabbits exposed to 0.2 to 1.0 mg/l (30 to 150 ppm) for 90 minutes daily for 5 weeks developed vascular hyperemia, hemorrhaging in most major organs, and fatty and protein dystrophy in the liver, kidney, and heart, and hyperplasia of the bone marrow. meta-Diisopropylbenzene caused decreased fertility in the rat and mouse at 1 to 3 mg/l for 30 days. |
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| Environmental Abiotic Degradation | The rate constant for the vapor-phase reaction of diisopropylbenzene with photochemically produced hydroxyl radicals has been estimated to be about 1.3X10-11 cu cm/molecule-sec at 25 °C which corresponds to an atmospheric half-life of about 30 hrs at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1). Benzenes are generally resistant to aqueous environmental hydrolysis(2), therefore, diisopropylbenzene is not expected to hydrolyze in the environment(SRC). |
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| TSCA-Inventar-Status | TSCA listed |
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| UN-Transportnummer | 3082 |
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| Zollcode | 29029000 |
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| RTECS-Nr. | CZ6330000 |
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| R-Sätze (R) | 10-37-51/53-65 |
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| Gefahrensymbole | Xn,N |
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| Sicherheitshinweise (S) | 24/25-62-61-37-24 |
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| Gefahrenklasse | 9 |
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| Verpackungsgruppe | III |
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| Gefahrstoffdaten | 25321-09-9(Hazardous Substances Data) |
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