HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diloxanid
RD3803 · RD 3803 · RD-3803 · Diloxanid · diloxanide · Diloxanida · diloxanide USP/EP/BP · Diloxanide, 10 mM in DMSO
Identifikatoren & physikalische Daten
| CAS No. | 579-38-4 |
|---|---|
| Summenformel | C9H9Cl2NO2 |
| Durchschnittliche Molmasse | 234,08 g/mol |
| Monoisotopische Masse | 233,0010339 g/mol |
| SMILES | CN(C(=O)C(Cl)Cl)c1ccc(O)cc1 |
| InChIKey | GZZZSOOGQLOEOB-UHFFFAOYSA-N |
| PubChem CID | 11367 |
| ChEMBL | CHEMBL2103768 |
| EC No. | 209-439-4 |
| DTXSID | DTXSID0022939 |
| Lokaler Name | Diloxanid |
Chemische & physikalische Eigenschaften
| XLogP | 2 |
|---|---|
| Polarare Oberfläche (TPSA) | 40,5 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 14 |
| Formalladung | 0 |
| Komplexität | 203 |
| Arzneimittel | Pharmaceuticals -> Listed in ZINC15 |
| LogP (Verteilungskoeffizient) | 1.78 |
| Human Drugs | Antiamoebic and antigiardiasis medicines |
| Schmelzpunkt | 175° |
| Siedepunkt | 356.2±42.0 °C(Predicted) |
| Dichte | 1.439±0.06 g/cm3(Predicted) |
| Lagerbedingungen | Store at -20°C |
| Löslichkeit | DMSO:33.33(Max Conc. mg/mL)142.39(Max Conc. mM) |
| Aggregatzustand | Solid |
| pKa (Säurekonstante) | 9.95±0.15(Predicted) |
| Farbe | Light brown to brown |
Anwendungen & Verwendung
Verwenden
Diloxanide is also active against cysts and trophozoites localized in the lumen of the intestine, and it is used for treating the carrier E. histolytica, as well as for treating asymptomatic or moderate forms of amebiasis. In the transition stage to trophozoites, the drug is less active than iodoquinol. A synonym of this drug is furamide.