(1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo(3.2.1)octane
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Grundinformationen
- CAS
195875-84-4- Standard-SMILES
CCOC[C@@H]1[C@@H](c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H]1N2C- InChIKey
VCVWXKKWDOJNIT-ZOMKSWQUSA-N- Summenformel
- C17H23Cl2NO
- Durchschnittliche Molmasse
- 328,283 g/mol
- Monoisotopische Masse
- 327,11566972
Namen und Bezeichner
- Bevorzugter Name
- (1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo(3.2.1)octane
- IUPAC
- (1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane
- Englischer Name
- tesofensine
- Summenformel
- C17H23Cl2NO
- Molmasse
- 328.28
Namen und Synonyme
Tesofensine-13C-d3Tesofensine 0.5mg TabletsTesofensine 500mcg Tablets(1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane(1S,3S,4R,5R)-3-(3,4-dichlorophenyl)-4-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane8-Azabicyclo[3.2.1]octane, 3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-, (1R,2R,3S,5S)-
Datenbank-Bezeichner
- CAS
195875-84-4- PubChem CID
- 11370864
- DTXSID
DTXSID70905114- ChEMBL
CHEMBL3989690- UNII
- BLH9UKX9V1
Eigenschaften
Physikochemische Eigenschaften
- Siedepunkt
- 396.6 · 396.6±42.0 °C(Predicted)
- Dichte
- 1.161 · 1.161±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- 2 mg/mL,DMSO: · DMF: 2 mg/mL,DMSO: 1 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.14 mg/mL
- Aggregatzustand
- A solid
- pka
- 10.46 · 10.46±0.60(Predicted)
- Farbe
- White to off-white
- Stabilität
- Hygroscopic
- InChI
- InChI=1S/C17H23Cl2NO/c1-3-21-10-14-13(9-12-5-7-17(14)20(12)2)11-4-6-15(18)16(19)8-11/h4,6,8,12-14,17H,3,5,7,9-10H2,1-2H3/t12-,13+,14+,17+/m0/s1
- InChIKey
- VCVWXKKWDOJNIT-ZOMKSWQUSA-N
- SMILES
- [C@@]12([H])N(C)[C@@]([H])(CC1)C[C@H](C1=CC=C(Cl)C(Cl)=C1)[C@H]2COCC
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- Alarmwort
- Warnung
- Gefahrenhinweise
- Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H315
Chemie und Industrie
Anwendungen
HistoryTesofensine is a dopamine, serotonin, and noradrenaline (triple) reuptake inhibitor originally developed by NeuroSearch for the treatment of Alzheimer's disease and Parkinson's disease. Development of the compound for these neurological indications was unsuccessful but significant weight loss was reported during the clinical trials in Parkinson's disease. Hence, tesofensine is now being developed by NeuroSearch for the treatment of obesity and type 2 diabetes[1].
VerwendenTesofensine, is a serotonin–noradrenaline–dopamine reuptake inhibitor from the phenyltropane family of drugs, which is currently in clinical development for the treatment of obesity.
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