Trimethylamin, in wässriger Lösung(C > 15%)
Methylamine, N,N-dimethyl- · TRIMETHYLAMINE HCL · FEMA 3241 · TRIMETHYLAMIN · Methanamine, N,N-dimethyl- · N, N-DIMETHYLMETHYLAMINE HCL · ai3-15639 · TMA solution
Identifikatoren & physikalische Daten
| CAS No. | 75-50-3 |
|---|---|
| Summenformel | C3H9N |
| Durchschnittliche Molmasse | 59,11 g/mol |
| Monoisotopische Masse | 59,07349929 g/mol |
| SMILES | CN(C)C |
| InChIKey | GETQZCLCWQTVFV-UHFFFAOYSA-N |
| PubChem CID | 1146 |
| ChEMBL | CHEMBL439723 |
| ChEBI | CHEBI:18139 |
| EC No. | 200-875-0 |
| DTXSID | DTXSID2026238 |
| Lokaler Name | Trimethylamin, in wässriger Lösung(C > 15%) |
Chemische & physikalische Eigenschaften
| XLogP | 0,3 |
|---|---|
| Polarare Oberfläche (TPSA) | 3,2 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 1 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 4 |
| Formalladung | 0 |
| Komplexität | 8 |
| Stoffklassen | Nitrogen Compounds -> Amines, AliphaticFlammable agents - 4th degree |
| Arzneimittel | Pharmaceuticals -> Metabolite of Levocarnitine |
| pH | Strong basea strong base (pH 9.8) |
| SpringerMaterials Properties | 15N nuclear magnetic resonance spectrum |
| Duftstoffe | Fragrance Ingredient (Trimethylamine) -> IFRA transparency List |
| LogP (Verteilungskoeffizient) | log Kow = 0.160.2-0.3 |
| Geruch | Pungent, fishy, ammoniacalFishy, amine odorA fish-like odor at low concentrations changing to an ammonia-like odor at higher concentrations. |
| Geschmack | Old fishSaline taste |
| Lebensmittelzusatzstoffe | FLAVORING AGENT OR ADJUVANT -> FDA Substance added to food |
| Dichte | 0.633 at 68 °F (USCG, 1999) - Less dense than waterwill float0.6356 (NTP, 1992) - Less dense than water0.6709 at 0 °C/4 °CSaturated liquid density= 40.890 lb/cu ft @ 35 °CSaturated vapor density= 0.29910 lb/cu ft @ 70 °CRelative density (water = 1): 0.6 (liquid)0.63 g/mL at 20 °C (lit.) |
| Aromastoffe | EU Flavoring substances |
| Viscosity | 5.1564X10-4 Pa.sec at 200 K |
| Schmelzpunkt | -117 °C (lit.) |
| Siedepunkt | 3-4 °C (lit.) |
| Dampfdichte | 2.09 (vs air) |
| Dampfdruck | 430 mm Hg ( 25 °C) |
| Brechungsindex | n20/D 1.357 |
| FEMA | 3241 | TRIMETHYLAMINE |
| Flammpunkt | 38 °F |
| Lagerbedingungen | Store at +5°C to +30°C. |
| Löslichkeit | very soluble in water, slightly soluble in alcohol, ether, benzene, toluene, xylene, ethylbenzene, chloroform maximum allowable concentration: TLV 10 p.p.m. (24 mg/m3) and STEL of 15 p.p.m. (36 mg/m3) (ACGIH 1986)Soluble In Water, 8.9e+005 mg/L. |
| Aggregatzustand | Liquid |
| pKa (Säurekonstante) | pKb (25°): 4.13 |
| Farbe | Colorless |
| Geruch | smelling like rotting fish, rotting eggs, garbage, or urine. |
| Geruchsart | fishy |
| Biologische Quelle | synthetic |
| Explosionsgrenze | 11.6% |
| Geruchsschwelle | 0.000032ppm |
| Spezifische Wärmekapazität | Cp(liquid): 2.33 J/(g·K)Cp(gas): 1.55 J/(g·K), at 25℃ |
| Merck | 14,9710 |
| JECFA Number | 1610 |
| BRN | 956566 |
| Henry-Konstante | 9.9×10-2 mol/(m3Pa) at 25℃, Burkholder et al. (2019) |
| Dielektrizitätskonstante | 2.9(4℃) |
| Stabilität | Stable. Incompatible with a wide variety of materials, including bases, acids, oxidizing agents, brass, zinc, magnesium, aluminium, mercury, mercury oxides, acid chlorides, acid anhydrides. Hygroscopic. Highly flammable. Readily forms explosive mixtures with air. |
| InChI | 1S/C3H9N/c1-4(2)3/h1-3H3 |
| InChIKey | GETQZCLCWQTVFV-UHFFFAOYSA-N |
| SMILES | CN(C)C |
| LogP (Verteilungskoeffizient) | 0.06 |
| CAS Datenbank | 75-50-3(CAS DataBase Reference) |
| EPA chemische Informationen | Trimethylamine (75-50-3) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH220: Extremely flammable gas [Danger Flammable gases]P203, P210, P222, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P332+P317, P362+P364, P377, P381, P403, P403+P233, P405, and P501 (click each P-code to see the statement)H224: Extremely flammable liquid and vapor [Danger Flammable liquids]P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) |
|---|---|
| Regulatorische Informationen | Chemical: Methanamine, N,N-dimethyl-Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)Methanamine, N,N-dimethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Methanamine, N,N-dimethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 08-09-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14936Trimethylamine, anhydrous: HSNO Approval: HSR001014 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| DOT-Kennzeichnung | Flammable GasFlammable Liquid Corrosive |
| Brandgefahren | FLAMMABLE. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. Vapor is heavier than air and may travel a considerable distance to a source of ignition and flash back. (USCG, 1999)Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:· Flammable/combustible material.· EXTREMELY FLAMMABLE.Extremely flammable. Gives off irritating or toxic fumes (or gases) in a fire. Gas/air mixtures are explosive.Extremely flammable. Gives off irritating or toxic fumes (or gases) in a fire. Vapour/air mixtures are explosive. |
| Brandpotenzial | Flammable gas. |
Anwendungen & Verwendung
Occurrence
TMA is widely distributed in the environment as a normal constituent of animal and plant tissue and as a result of its formation during the decay of organic matter in plants, animals, fish, sewage and animal waste (Graedel 1978; Hippe et al 1977; Oremland et al 1982). The amine is formed primarily as the result of microbial degradation of the plant and animal constituents betaine and choline and from bacterial reduction of trimethylamine oxide, a common constituent of aquatic organisms. It also occurs naturally in a variety of foodstuffs and in tobacco smoke and these are the most likely sources of human exposure (HSDB 1988).Numerous strains of bacteria isolated from various sources have been found capable of growing on TMA (HSDB 1988). Degradation products formed under anaerobic conditions include dimethylamine, formaldehyde, formate and C02, while under aerobic conditions, TMA is converted to dimethylamine, ammonia and methane.
Verwenden
Trimethylamine is used as a warning agent for natural gas, a synthetic flavor (fish) ingredient, and in the synthesis of photochemicals, choline salts, flotation agents, dyes, pesticides, ion-exchange resins, cationic starches, and intense sweeteners (HSDB 2006). Organic synthesis, especially of choline salts, warning agent for natural gas, manufacture of disinfectants, flotation agent, insect attractant, quaternary ammonium compounds, plastics.
Herstellung & Synthese
synthetische
Trimethylamine can be synthesized from paraformaldehyde and ammonium chloride, by the reaction of formic acid, formaldehyde, and ammonia, and by interaction of methanol and ammonia with a catalyst at high temperature.