Territrem A

BeschreibungTerritrem A is a mycotoxin originally isolated from A. terreus that irreversibly inhibits acetylcholinesterase (AChE; IC50 = 24 nM for the electric eel enzyme). It is toxic to mice, inducing tremors with a median tremulous dose of 0.31 mg/kg, and has an LD50 value of 17.6 mg/kg.

VerwendenTerritrem A is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem A is a potent insecticide acting via irreversible inhibition of acetylcholinesterase (AChE). The binding mechanism is very different from typical irreversible AChE inhibitors like neostigmine and the organophospates.