HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Lasmiditan
LasMiditan (COL-144 · 2,4-difluoro-N-(6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl)benzamide · CS-2381 · COL 144 · LY573144 · Lamiditam · Lamiditan · LasMiditan
Identifikatoren & physikalische Daten
| CAS No. | 439239-90-4 |
|---|---|
| Summenformel | C19H18F3N3O2 |
| Durchschnittliche Molmasse | 377,4 g/mol |
| Monoisotopische Masse | 377,13511148 g/mol |
| SMILES | CN1CCC(C(=O)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 |
| InChIKey | XEDHVZKDSYZQBF-UHFFFAOYSA-N |
| PubChem CID | 11610526 |
| ChEMBL | CHEMBL3039520 |
| DTXSID | DTXSID40469435 |
Chemische & physikalische Eigenschaften
| XLogP | 2,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 62,3 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 7 |
| Frei drehbare Bindungen | 4 |
| Schwere Atome | 27 |
| Formalladung | 0 |
| Komplexität | 530 |
| Arzneimittel | DEA Schedule V Controlled Substance -> DepressantsPharmaceuticals -> UnknownPharmaceuticals -> Listed in ZINC15 |
| Human Drugs | Breast FeedingLactationSerotonin Receptor AgonistsSerotonin 5-HT1 Receptor AgonistsVasoconstrictor AgentsFDA approved drugs -> Active ingredientEMA approved medicines: Human medicine |
| Schmelzpunkt | 255℃ |
| Siedepunkt | 433.3±45.0 °C(Predicted) |
| Dichte | 1.351 |
| Lagerbedingungen | -20°C Freezer, Under inert atmosphere |
| Löslichkeit | Chloroform (Slightly), DMSO (Slightly) |
| pKa (Säurekonstante) | 9.91±0.70(Predicted) |
| Aggregatzustand | Solid |
| Farbe | White to Off-White |
Sicherheit & Vorschriften
| Regulatorische Informationen | DEA schedule V controlled substance |
|---|---|
| Hepatotoxicity | In preregistration controlled trials of lasmiditan in several thousand patients, mild-to-moderate serum aminotransferase elevations arose in a small percentage of patients (1% or less) and overall rates were not different from those in placebo recipients. In the controlled trials and subsequently with general use, there have been no reports of liver injury with symptoms or jaundice attributed to lasmiditan. |
| Effects During Pregnancy and Lactation | ◉ Summary of Use during Lactation |
| Alarmwort | Warnung |
| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H319 |
Anwendungen & Verwendung
Beschreibung
Lasmiditan (Item No. 28369) is an analytical reference standard categorized as an agonist of the serotonin (5-HT) receptor subtype 5-HT1F. Formulations containing lasmiditan have been used in the treatment of migraine headache. Lasmiditan has low abuse potential. Lasmiditan is regulated as a Schedule V compound in the United States. This product is intended for research and forensic applications.
Verwenden
Lasmiditan is used in diagnosing, treating and/or preventing periodontal disease and/or tooth loss.