Pulchinenoside B4
Anemoside B4 · Pulchinenoside C · Anemoside B4 Pulchinenoside B4 · Chinensioside A · PULCHINENOSIDE B4 · Pulsatilla saponin B4 · Pulchinenoside B4 CRS · AnemosideB4 129741-57-7
Identifikatoren & physikalische Daten
| CAS No. | 129741-57-7 |
|---|---|
| Summenformel | C59H96O26 |
| Durchschnittliche Molmasse | 1.221,4 g/mol |
| Monoisotopische Masse | 1.220,61898316 g/mol |
| SMILES | C=C(C)[C@@H]1CC[C@]2(C(=O)O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O[C@@H]6OC[C@H](O)[C@H](O)[C@H]6O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O)[C@@](C)(CO)[C@@H]5CC[C@]43C)[C@@H]12 |
| InChIKey | OUHBKBTZUPLIIA-OTEDBJMHSA-N |
| PubChem CID | 11636713 |
| ChEMBL | CHEMBL450226 |
Chemische & physikalische Eigenschaften
| XLogP | -1,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 413 |
| H-Brücken-Donoren | 15 |
| H-Brücken-Akzeptoren | 26 |
| Frei drehbare Bindungen | 15 |
| Schwere Atome | 85 |
| Formalladung | 0 |
| Komplexität | 2.340 |
| Schmelzpunkt | 208-215℃ |
| Dichte | 1.48 |
| Löslichkeit | DMSO : 125 mg/mL (102.34 mMNeed ultrasonic) |
| Aggregatzustand | Powder |
| pKa (Säurekonstante) | 12.50±0.70(Predicted) |
| Farbe | White to light yellow |
| Hauptanwendungen | pharmaceutical |
| InChIKey | OUHBKBTZUPLIIA-UFEMLMIJNA-N |
Anwendungen & Verwendung
Beschreibung
Pulchinenoside B4 is a triterpenoid glycoside that has been found in P. chinensis and has diverse biological activities. It inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities in HEK293 cells when used at concentrations of 6 and 12 μM. Pulchinenoside B4 (50 and 100 mg/kg twice per day) prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels, markers of kidney injury, in a mouse model of cisplatin-induced nephrotoxicity. It prevents xylene-induced ear edema in mice in a dose-dependent manner. Pulchinenoside B4 (50 mg/kg) inhibits LPS-induced increases in serum TNF-α, IL-6, and IL-1β levels a mouse model of LPS-induced systemic inflammation.
Verwenden
Pulchinenoside C is a triterpenoid saponin extract which acts as a minor molluscicidal agent in addition to tumor necrosis factor-α secretion inhibition. Anti-inflammatory.