CP 94253 hydrochloride
Grundinformationen
- CAS
845861-39-4- Standard-SMILES
CCCOc1ccc2[nH]cc(C3=CCNCC3)c2n1.Cl- InChIKey
PIIOXKQIZCVXMD-UHFFFAOYSA-N- Summenformel
- C15H20ClN3O
- Durchschnittliche Molmasse
- 293,79 g/mol
- Monoisotopische Masse
- 293,12949
Namen und Bezeichner
- Bevorzugter Name
- CP 94253 hydrochloride
- IUPAC
- 5-propoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[3,2-b]pyridine;hydrochloride
- Englischer Name
- CP 94253 hydrochloride
- Summenformel
- C15H20ClN3O
- Molmasse
- 293.8
Namen und Synonyme
CP 94253 hydrochloride845861-39-4131084-35-0CP94253 hydrochlorideCP94253 (hydrochloride)CP94253 HCl5-propoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[3,2-b]pyridine hydrochloride5-propoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[3,2-b]pyridine;hydrochloride5-PROPOXY-3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-PYRROLO[3,2-B]PYRIDINE hydrochloride5-PROPOXY-3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-PYRROLO[3,2-B]PYRIDINEHYDROCHLORIDECP 94253 HCl1H-Pyrrolo[3,2-b]pyridine, 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-,monohydrochloride
Weitere Namen anzeigen
CP94253 hydrochloride, 10 mM in DMSOCP 94253 dihydrochloride, 5-HT1B agonistCP94253,CP94253 hydrochloride,Serotonin Receptor,inhibit,CP 94253,CP-94253,5-hydroxytryptamine Receptor,Inhibitor,5-HT Receptor
CP 94253 dihydrochlorideorb1305849SCHEMBL2159345CHEMBL5087653DTXSID401336802VIB86139EX-A11530HB1671
Datenbank-Bezeichner
- CAS
845861-39-4- PubChem CID
- 11652258
- DTXSID
DTXSID401336802- ChEMBL
CHEMBL5087653
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 49,9 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 20
- Formalladung
- 0
- Komplexität
- 331
Physikochemische Eigenschaften
- storage temp.
- Desiccate at RT
- Löslichkeit
- 25 mM · Soluble to 25 mM in water and to 100 mM in DMSO
- Aggregatzustand
- Powder
- Farbe
- Pale yellow
- InChI
- InChI=1S/C15H19N3O.ClH/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11;/h3-5,10,16-17H,2,6-9H2,1H3;1H
- InChIKey
- PIIOXKQIZCVXMD-UHFFFAOYSA-N
- SMILES
- O(C1=CC=C2NC=C(C3=CCNCC3)C2=N1)CCC.Cl
Chemie und Industrie
Anwendungen
BeschreibungCP 94,253 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B (Ki = 2 nM in a radioligand binding assay). It is selective for 5-HT1B over 5-HT1A, 5-HT1D, 5-HT1C, and 5-HT2 receptors (Kis = 89, 49, 860, and 1,600 nM, respectively). CP 94,253 (10 and 17 mg/kg) reduces aggressive behavior in a resident-intruder test in mice, as well as decreases alcohol-induced aggression in mice with an ED50 value of 3.8 mg/kg. It decreases the time mice spend immobile in the forced swim test by 43%, indicating antidepressant-like activity, when administered at a dose of 5 mg/kg. CP 94,253 (2.5 mg/kg) also increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats.
VerwendenCP 94253 Hydrochloride is a potent and selective serotonin 5-HT1B receptor agonist with anticonvulsant activity.
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Notizen zur Verbindung
Wird geladen…