| GHS-Einstufung | DangerH302 (96.6%): Harmful if swallowed [Warning Acute toxicity, oral]P260, P261, P262, P264, P270, P271, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P320, P321, P330, P361+P364, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 58 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
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| Regulatorische Informationen | Status: Active Update: 06-01-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/11864Ethanesulphonyl chloride: Does not have an individual approval but may be used under an appropriate group standard |
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| Gefahrenübersicht | A lachrymatorAll rats exposed to 1273 ppm died within 30 to 130 minutes4-hr LC50 (rat) = approximately 86 ppmRats exposed to lethal concentrations have lacrimation, salivation, gasping, and pulmonary hemorrhage[HSDB] Reacts violently with waterA corrosive substance that can cause injury to the skin, eyes, and respiratory tractInhalation may cause chemical pneumonitisEffects in high-dose animal studies include acute pulmonary edema[MSDSonline] |
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| Hazard Classes and Categories | Acute Tox. 4 (96.6%) |
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| Skin, Eye, and Respiratory Irritations | /Ethanesulfonyl chloride is a/ lachrymator ... |
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| Entsorgungsverfahren | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations. |
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| Preventive Measures | SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning. |
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| Unerwünschte Wirkungen | Dermatotoxin - Skin burns. |
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| Human Toxicity Excerpts | /SIGNS AND SYMPTOMS/ /Ethanesulfonyl chloride is a/ lachrymator ... |
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| Non-Human Toxicity Excerpts | /LABORATORY ANIMALS: Acute Exposure/ A single dermal application of 2000 mg/kg to rabbits killed two of three animals. No deaths occurred following a dermal application of 200 mg/kg to rabbits./LABORATORY ANIMALS: Acute Exposure/ Acute (4-hr) inhalation studies indicated an LC50 of approximately 86 ppm in the rat. Clinical signs included eye irritation, lacrimation, salivation, and gasping. Decedents exhibited pulmonary hemorrhage. All rats died within 30 to 130 min during an exposure to 1273 ppm./LABORATORY ANIMALS: Acute Exposure/ Ethanesulfonyl chloride is corrosive to rabbit skin and eyes, and the vapor caused irritation of the eyes and respiratory tract. In rabbits, irritation of the eye 20 to 30 sec after instillation did not reduce the conjunctival necrosis, corneal opacity, or iridial changes. Corneal opacity persisted through 7 days. |
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| Toxicity Data | LCLo (rat) = 410 mg/m3/4h |
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| Non-Human Toxicity Values | LD50 rat oral 360 mg/kgLC50 rat inhalation 86 ppm/4 hr |
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| F | 19-21 |
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| Wassergefährdungsklasse (WGK) | 3 |
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| TSCA-Inventar-Status | TSCA listed |
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| UN-Transportnummer | UN 2927 6.1/PG 2 |
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| Zollcode | 29049090 |
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| RTECS-Nr. | KI8050000 |
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| R-Sätze (R) | 21/22-23-34-22 |
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| Gefahrensymbole | T |
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| Sicherheitshinweise (S) | 26-36/37/39-45 |
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| Gefahrenklasse | 6.1Acute Tox. 2 InhalationAcute Tox. 4 DermalAcute Tox. 4 OralEye Dam. 1Skin Corr. 1BSTOT SE 3 |
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| Verpackungsgruppe | II |
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| Lagerklasse | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
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| Gefahrstoffdaten | 594-44-5(Hazardous Substances Data) |
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