N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride
Grundinformationen
- CAS
97075-46-2- Standard-SMILES
Cl.Cl.c1ccc(C(NCCNC(c2ccccc2)c2ccccc2)c2ccccc2)cc1- InChIKey
YRQCDCNQANSUPB-UHFFFAOYSA-N- Summenformel
- C28H30Cl2N2
- Durchschnittliche Molmasse
- 465,5 g/mol
- Monoisotopische Masse
- 464,1786044
Überblick
AMN082 dihydrochloride is a hydrochloride obtained by combining N,N'-bis(diphenylmethyl)ethane-1,2-diamine with two molar equivalent of hydrochloric acid. It has a role as a geroprotector, a metabotropic glutamate receptor agonist and a neuroprotective agent. It contains a N,N'-bis(diphenylmethyl)ethane-1,2-diamine(2+).
Namen und Bezeichner
- Bevorzugter Name
- N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride
- IUPAC
- N,N'-dibenzhydrylethane-1,2-diamine;dihydrochloride
- Englischer Name
- 1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride
- Summenformel
- C28H29ClN2
- Molmasse
- 429
Namen und Synonyme
N,N'-Dibenzhydrylethane-1,2-diamine dihydrochlorideDTXSID701017562RefChem:926417DTXCID20147574997075-46-2AMN082 DIHYDROCHLORIDEAMN 082 dihydrochloride83027-13-8N1,N2-Dibenzhydrylethane-1,2-diamine dihydrochlorideAMN 082 (Free base)N,N'-bis(diphenylmethyl)-1,2-ethanediamine dihydrochlorideAMN082 free base
Weitere Namen anzeigen
N,N'-dibenzhydrylethane-1,2-diamineAMN082 dihydrochloride, mGlu7 agonist1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride
N,N'-dibenzhydrylethane-1,2-diamine;dihydrochlorideN,N'-dibenzhydrylethylenediamine dihydrochlorideN,N'-dibenzhydryl-1,2-ethanediamine dihydrochlorideN,N inverted exclamation marka-bis(diphenylmethyl)-1,2-ethanediamine, dihydrochlorideAMN082 HClC28H30Cl2N2N,N/'-dibenzhydrylethane-1,2-diamine;dihydrochlorideorb1217420
Datenbank-Bezeichner
- CAS
97075-46-2
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 24,1 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 9
- Schwere Atome
- 32
- Formalladung
- 0
- Komplexität
- 362
Physikochemische Eigenschaften
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- 46.55 mg/ml · <46.55mg/ml in DMSO;insoluble in H2O
- Aggregatzustand
- solid
- Farbe
- White
- InChI
- 1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H
- InChIKey
- YRQCDCNQANSUPB-UHFFFAOYSA-N
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- WGK 3
- risk_code
- 22-50
- hazard_code
- Xn,N
- safety_code
- 61
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
BeschreibungAMN082 is an orally bioavailable allosteric agonist of metabotropic glutamate receptor 7 (mGluR7). It inhibits cAMP accumulation induced by forskolin in CHO cells expressing human mGluR7b (EC50 = 64 nM). AMN082 (10 μM) is selective for mGluR7a and mGluR7b over mGluR1b, mGluR4, and mGluR8a with 140, 90, 15, 18, and 20% activation, respectively, as well as over mGluR2, mGluR3, mGluR5a, mGluR6, GluR3, and NMDA receptors containing NR1a, NR2A, or NR2B subunits. AMN082 also binds to the norepinephrine transporter (NET) and α1-adrenergic receptor (α1-AR). It increases the proliferation of neural progenitor cells (NPCs) and induces their differentiation into neurons when used at a concentration of 1 μM. AMN082 (2.5 mg/kg) inhibits apomorphine-induced circling in a rat model of Parkinson''s disease induced by 6-hydroxy dopamine (6-OHDA; ).
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