Uracil
Daten werden ergänzt – lade die Seite später neu, um den aktuellen Stand zu sehen
Grundinformationen
- CAS
24897-50-5- Standard-SMILES
O=c1cc[nH]c(=O)[nH]1- InChIKey
ISAKRJDGNUQOIC-UHFFFAOYSA-N- Summenformel
- C4H4N2O2
- Durchschnittliche Molmasse
- 112,09 g/mol
- Monoisotopische Masse
- 112,02727738
Überblick
Uracil is a common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription. It has a role as a prodrug, an allergen, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite and a Daphnia magna metabolite. It is a pyrimidine nucleobase and a pyrimidone. It is a tautomer of a (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one.
Namen und Bezeichner
- Bevorzugter Name
- Uracil
- IUPAC
- 1H-pyrimidine-2,4-dione
- Englischer Name
- URACIL-5-D1
- Summenformel
- C4H3DN2O2
- Molmasse
- 113.09
Namen und Synonyme
uracil66-22-8pyrimidine-2,4(1H,3H)-dione2,4(1H,3H)-PyrimidinedionePyrodPirodHybar X2,4-Dioxopyrimidine2,4-Pyrimidinedione1H-Pyrimidine-2,4-dione1,2,3,4-tetrahydropyrimidine-2,4-dioneDTXSID4021424
Weitere Namen anzeigen
Nsc29742Uracil-5-Uracil-5-DURACIL-5-D1[6-2H]-UracilURACIL (5-D, 98%)
56HH86ZVCTNSC-3970SQ-6201SQ-7726SQ-8493CHEBI:17568BMS-205603-01NSC3970
Datenbank-Bezeichner
- CAS
24897-50-5、2920-92-5、51953-14-1、51953-20-9、66-22-8- PubChem CID
- 1174
- DTXSID
DTXSID4021424- ChEMBL
CHEMBL566- ChEBI
CHEBI:17568- UNII
- 56HH86ZVCT
- EC Number
- 200-621-9
- Nikkaji
- J4.842I
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- -1,1
- Polarare Oberfläche (TPSA)
- 58,2 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 8
- Formalladung
- 0
- Komplexität
- 161
Experimentelle und physikochemische Eigenschaften
Chemical ClassesBiological Agents -> Nucleic Acids and Derivatives
Drugs
Pharmaceuticals -> Listed in ZINC15
Pharmaceuticals
SpringerMaterials Properties15N nuclear magnetic resonance spectrum
LogP
-1.07
-1.0
Solubility3.6 mg/mL
Melting Point330 °C
Physical Description
Solid; [Merck Index] White powder; [Alfa Aesar MSDS]
Solid
Ionization Efficiency
Positive
0.68
2.7
Agilent XCT
Electrospray ionization
formic acid (5.3nM)
Dissociation Constants9.45
Collision Cross Section
126.98 Ų [M+H]+ [CCS Type: DT; Method: stepped-field]
115 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine]
112.9 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
118.5 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
126.2 Ų [M+H]+
Physikochemische Eigenschaften
- CAS Number Unlabeled
- 66 · 66-22-8
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 82.4% (14 of 17) of all reports.
Warning
H315 (11.8%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 17 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
REACH registered substance: Dihydroxypyrimidine (EC: 454-380-1)
REACH registered substance: Uracil (EC: 200-621-9)
2,4(1H,3H)-Pyrimidinedione: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 2,4(1H,3H)-Pyrimidinedione: Environment tier I assessment
Hazards SummaryMay cause irritation; [Alfa Aesar MSDS] See Uracil.
Hazard Classes and CategoriesSkin Irrit. 2 (11.8%)
Chemie und Industrie
Pharmakologische Informationen
Tissue LocationsAll Tissues
Cellular LocationsExtracellular
Metabolite PathwaysBeta Ureidopropionase Deficiency
Verwendung und Herstellung
Uses
Produced by hydrolysis of nucleic acids; Used in biochemical research; [Merck Index]
Use (kg; approx.) in Germany (2009): >10
General Manufacturing Information2,4(1H,3H)-Pyrimidinedione: ACTIVE
Anwendungen
VerwendenUracil-d can be used to treat Hepatitis C, HSV, RSV, HCV, and as an anti-tumor agent.
Zugehörige Reaktionen
164
Notizen zur Verbindung
Wird geladen…