Uracil

HCID 1174CAS 24897-50-5

Grundinformationen

Standard-SMILES
O=c1cc[nH]c(=O)[nH]1
InChIKey
ISAKRJDGNUQOIC-UHFFFAOYSA-N
Summenformel
C4H4N2O2
Durchschnittliche Molmasse
112,09 g/mol
Monoisotopische Masse
112,02727738

Namen und Bezeichner

Bevorzugter Name
Uracil
IUPAC
1H-pyrimidine-2,4-dione
Englischer Name
URACIL-5-D1
Summenformel
C4H3DN2O2
Molmasse
113.09

Namen und Synonyme

uracil66-22-8pyrimidine-2,4(1H,3H)-dione2,4(1H,3H)-PyrimidinedionePyrodHybar X2,4-DioxopyrimidinePirod2,4-Pyrimidinedione1H-Pyrimidine-2,4-dione1,2,3,4-tetrahydropyrimidine-2,4-dioneDTXSID4021424
Weitere Namen anzeigen
Nsc29742Uracil-5-Uracil-5-DURACIL-5-D1[6-2H]-UracilURACIL (5-D, 98%)
NSC-3970SQ-6201SQ-7726SQ-8493CHEBI:17568BMS-205603-0156HH86ZVCTNSC3970

Datenbank-Bezeichner

CAS
24897-50-5、2920-92-5、51953-14-1、51953-20-9、66-22-8
PubChem CID
1174
DTXSID
DTXSID4021424
ChEMBL
CHEMBL566
ChEBI
CHEBI:17568
UNII
56HH86ZVCT
EC Number
200-621-9
Nikkaji
J4.842I

Eigenschaften

Berechnete Struktureigenschaften

XLogP
-1,1
Polarare Oberfläche (TPSA)
58,2 Ų
H-Brücken-Donoren
2
H-Brücken-Akzeptoren
2
Frei drehbare Bindungen
0
Schwere Atome
8

Experimentelle und physikochemische Eigenschaften

LogP · 2 Einträge

-1.07

-1.07

LogS-1.48
Solubility · 2 Einträge

3600

3.6 mg/mL

Melting Point · 2 Einträge

338

330 °C

Caco2 Permeability-5.37
Physical Description · 2 Einträge

Solid; [Merck Index] White powder; [Alfa Aesar MSDS]

Solid

Physikochemische Eigenschaften

CAS Number Unlabeled
66 · 66-22-8

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 6 Einträge

This chemical does not meet GHS hazard criteria for 82.4% (14 of 17) of all reports.

Warning

H315 (11.8%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (11.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (11.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 17 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Reported as not meeting GHS hazard criteria per 14 of 17 reports by companies.;There are 3 notifications provided by 3 of 17 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

Regulatory Information · 2 Einträge

Status: Active Update: 31-01-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19811

2,4(1H,3H)-Pyrimidinedione: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - 2,4(1H,3H)-Pyrimidinedione: Environment tier I assessment;IMAP assessments - 2,4(1H,3H)-Pyrimidinedione: Human health tier I assessment
Hazards SummaryMay cause irritation; [Alfa Aesar MSDS] See Uracil.
Hazard Classes and CategoriesSkin Irrit. 2 (11.8%);Eye Irrit. 2A (11.8%);STOT SE 3 (11.8%)

Regulatorische Informationen

Regulatory Information · 2 Einträge

Status: Active Update: 31-01-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19811

2,4(1H,3H)-Pyrimidinedione: Does not have an individual approval but may be used under an appropriate group standard

Chemie und Industrie

Pharmakologische Informationen

Tissue LocationsAll Tissues;Placenta;Prostate
Cellular LocationsExtracellular
Metabolite Pathways · 1 Eintrag

Beta Ureidopropionase Deficiency;beta-Alanine metabolism;Carnosinuria, carnosinemia;Dihydropyrimidinase Deficiency;GABA-Transaminase Deficiency;MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy);Pyrimidine metabolism;UMP Synthase Deficiency (Orotic Aciduria);Ureidopropionase Deficiency

Verwendung und Herstellung

Uses · 2 Einträge

Produced by hydrolysis of nucleic acids; Used in biochemical research; [Merck Index]

Use (kg; approx.) in Germany (2009): >10;Consumption (g per capita; approx.) in Germany (2009): 0.000122;Calculated removal (%): 75.1

General Manufacturing Information2,4(1H,3H)-Pyrimidinedione: ACTIVE

Anwendungen

VerwendenUracil-d can be used to treat Hepatitis C, HSV, RSV, HCV, and as an anti-tumor agent.

Anbieter11 Anbieter

常州科化生物科技有限公司0519-68985668 13685222090 · [email protected]
济南德迈医药科技有限公司18669728830 15806766175 · [email protected]
江苏艾康生物医药研发有限公司025-66113011 13913916777 · [email protected]
上海贤鼎生物科技有限公司4009209199 · [email protected]
上海昶衍化工科技有限公司021-20242659 18930833303 · [email protected]

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