N-hydroxy-1-naphthalenamine
Grundinformationen
- CAS
607-30-7- Standard-SMILES
ONc1cccc2ccccc12- InChIKey
CWFINLADSFPMHF-UHFFFAOYSA-N- Summenformel
- C10H9NO
- Durchschnittliche Molmasse
- 159,18 g/mol
- Monoisotopische Masse
- 159,06841391
Überblick
N-hydroxynaphthalen-1-amine is a N-substituted amine. It is functionally related to a 1-naphthylamine.
Namen und Bezeichner
- Bevorzugter Name
- N-hydroxy-1-naphthalenamine
- IUPAC
- N-naphthalen-1-ylhydroxylamine
- Englischer Name
- N-hydroxy-1-naphthylamine
- Summenformel
- C10H9NO
- Molmasse
- 159.18
Namen und Synonyme
1-NAPHTHYLHYDROXYLAMINEN-Hydroxy-1-naphthylamineN-Hydroxy-1-naphthalenamine1-Hydroxyaminonaphthalenealpha-Naphthylhydroxylamine607-30-7N-1-NaphthylhydroxylamineHydroxylamine, N-1-naphthyl-1-Naphthalenamine, N-hydroxy-5O045G232PDTXSID40209510RefChem:76546
Weitere Namen anzeigen
N-(1-Naphtyl)hydroxylamine(Z)-naphthalen-1(8aH)-one oxiMe
DTXCID90132001N-Hydroxy-1-aminonaphthaleneN-(naphthalen-1-yl)hydroxylamineN-naphthalen-1-ylhydroxylamineN-hydroxynaphthalen-1-amineCCRIS 1175HSDB 2142BRN 2638939
Datenbank-Bezeichner
- CAS
607-30-7- PubChem CID
- 11828
- DTXSID
DTXSID40209510- ChEMBL
CHEMBL261899- ChEBI
CHEBI:34871- UNII
- 5O045G232P
- Nikkaji
- J2.985H
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,4
- Polarare Oberfläche (TPSA)
- 32,3 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 1
- Schwere Atome
- 12
- Formalladung
- 0
- Komplexität
- 149
Experimentelle und physikochemische Eigenschaften
Chemical ClassesNitrogen Compounds -> Naphthylamines
Physikochemische Eigenschaften
- Schmelzpunkt
- 79 °C · 79°C
- Siedepunkt
- 284.68 °C · 284.68°C (rough estimate)
- Dichte
- 1.1202 · 1.1202 (rough estimate)
- Brechungsindex
- 1.546 · 1.5460 (estimate)
- pka
- 9 · 9.00±0.30(Predicted)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Gefahrenhinweise
Hazards SummaryA strong eye and mucous membrane irritant; A corrosive substance that may cause damage to skin; [HSDB] Tumorigenic; [RTECS] See beta-Naphthylamine and alpha-Naphthylamine.
Toxikologische Informationen
Adverse EffectsDermatotoxin - Skin burns.
Human Toxicity Excerpts
...CORROSIVE TO SKIN & HIGHLY IRRITANT TO EYES & MUCOUS MEMBRANES. REPEATED EXPOSURE MAY ENHANCE ALLERGIC REACTION PARTICULARLY OF BACK OF HANDS & FOREARMS FROM 1-2 WK TO 2-5 YR AFTER COMMENCEMENT OF EXPOSURE & CASES OF ECZEMA...FOLLOWING PROLONGED CONTACT. ... NO CASES OF SYSTEMIC POISONING...IN WORKERS. /HYDROXYLAMINE/
/HYDROXYLAMINE IS/ ABOUT EQUIPOTENT TO NITRITE AS METHEMOGLOBIN FORMER, BUT IT HAS GREATER TENDENCY TO PRODUCE SULFHEMOGLOBIN, HEINZ BODIES & OTHER IRREVERSIBLE RED CELL DAMAGE. /PRC: N-1-NAPHTHYLHYDROXYLAMINE IS NOT EXPECTED TO CAUSE EXTENSIVE METHEMOGLOBIN WHEN COMPARED TO HYDROXYLAMINE./ ... SYSTEMIC POISONING CHARACTERIZED BY CYANOSIS, CONVULSIONS & COMA. /HYDROXYLAMINE/
Non-Human Toxicity Excerpts
/HIGH CONCN/ IN ANIMALS...CAUSES CONVULSIONS FOLLOWED BY PARALYSIS & DEATH FROM CESSATION OF BREATHING... CHRONIC ABSORPTION OF MODERATE DOSES (1 MG/KG) MAY LEAD TO SLIGHT ANEMIA. /HYDROXYLAMINE/
...INHIBITOR OF CATALASE &...WHEN ADMIN PARENTERALLY, 40 MG CAUSING CONVULSIONS, NYSTAGMUS & DEATH IN RABBIT. LOCAL APPLICATION OF 10% SOLN...TO RABBIT EYES...CAUSED MODERATE INFLAMMATION OF CONJUNCTIVA. /HYDROXYLAMINE/
HYDROXYLAMINE ELEVATES BRAIN GABA /GAMMA-AMINOBUTYRIC ACID/ LEVELS IN RATS. /HYDROXYLAMINE/
CHEMICAL SYNTHESIS OF 1-NAPHTHYLHYDROXYLAMINE SHOWED THAT THIS COMP IS TUMORIGENIC IN /RATS/ & MORE POTENT THAN 2-NAPHTHYLHYDROXYLAMINE. NEITHER COMPD INDUCES BLADDER TUMORS IN /RATS/ BUT BOTH CAUSE LIVER TUMORS.
For more Non-Human Toxicity Excerpts (Complete) data for 1-NAPHTHYLHYDROXYLAMINE (6 total), please visit the HSDB record page.
Chemie und Industrie
Pharmakologische Informationen
Mechanism of ActionTHE CARCINOGEN N-HYDROXY-1-NAPHTHYLAMINE REACTED WITH NUCLEIC ACID & PROTEIN UNDER SLIGHTLY ACIDIC CONDITIONS (PH5) TO FORM COVALENTLY BONDED DERIV WITH 3 TO 20 NAPHTHYL RESIDUES/1000 MONOMER UNITS.
Anbieter2 Anbieter
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
上海指月生物科技有限公司13918644899 · [email protected]
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