Mozavaptan
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Grundinformationen
- CAS
137975-06-5- Standard-SMILES
Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(N(C)C)c3ccccc32)cc1- InChIKey
WRNXUQJJCIZICJ-UHFFFAOYSA-N- Summenformel
- C27H29N3O2
- Durchschnittliche Molmasse
- 427,548 g/mol
- Monoisotopische Masse
- 427,22597717
Namen und Bezeichner
- Bevorzugter Name
- Mozavaptan
- IUPAC
- N-{4-[5-(Dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl]phenyl}-2-methylbenzamide
- Englischer Name
- Mozavaptan
- Summenformel
- C27H29N3O2
- Molmasse
- 427.54
Namen und Synonyme
CS-134OPC31260lOPC 31260MOZAVAPTANMozavaptan USP/EP/BPMozavaptan (OPC-31260)N-(4-(5-(Dimethylamino)Mozavaptan, 10 mM in DMSOOPC-31260OPC31260LOPC 31260-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)
Datenbank-Bezeichner
- CAS
137975-06-5- PubChem CID
- 119369
- DTXSID
DTXSID8057641- ChEMBL
CHEMBL420762- ChEBI
CHEBI:135694- UNII
- 17OJ42922Y
- Nikkaji
- J464.170A
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 213 · 213 - 217°C
- Siedepunkt
- 543 · 543.0±50.0 °C(Predicted)
- Dichte
- 1.21 · 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 13.04 · 13.04±0.70(Predicted)
- Farbe
- White to Off-White
- InChIKey
- WRNXUQJJCIZICJ-UHFFFAOYSA-N
- SMILES
- C(NC1=CC=C(C(N2C3=CC=CC=C3C(N(C)C)CCC2)=O)C=C1)(=O)C1=CC=CC=C1C
Chemie und Industrie
Anwendungen
BeschreibungMozavaptan is an oral vasopressin V2 antagonist that has been launched in Japan for inappropriate antidiuretic hormone secretion syndrome (IADHS), an affliction manifesting as hyponatremia. It joins another nonpeptidic benzazepine, conivaptan, which corrects sodium and water imbalance by blocking the renal V2 receptor resulting in enhanced diuresis, thereby effectively increasing serum sodium concentration. While conivaptan inhibits both V1 and V2 receptors, mozavaptan is significantly more selective for V2 (IC50 of 14nM vs. 1.2 mM for V1).
VerwendenMozavaptan is a vasopressin-receptor antagonist. It is used in the treatment of congestive heart failure and hyponatremia.
Anbieter100 Anbieter
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
陕西缔都新材料有限公司81124267 17392282731 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd+86-13119157289 · [email protected]
Suzhou ARTK Medchem Co., Ltd.+86-18168183658 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
江苏南创化学与生命健康研究院有限公司15720605021 · [email protected]
南京腾怡生物科技有限公司17714337195 · [email protected]
北京索莱宝科技有限公司
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