Uridin-5'-(trihydrogen-diphosphat), Dinatriumsalz
Disodium uridine 5'-diphosphate
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Grundinformationen
- CAS
27821-45-0- Standard-SMILES
O=c1ccn([C@@H]2O[C@H](COP(=O)([O-])OP(=O)([O-])O)[C@@H](O)[C@H]2O)c(=O)[nH]1.[Na+].[Na+]- InChIKey
ZQKVPFKBNNAXCE-WFIJOQBCSA-L- Summenformel
- C9H12N2Na2O12P2
- Durchschnittliche Molmasse
- 448,12 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Disodium uridine 5'-diphosphate
- IUPAC
- disodium;[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] hydrogen phosphate
- Lokaler Name
- Uridin-5'-(trihydrogen-diphosphat), Dinatriumsalz
- Englischer Name
- Uridine-5'-diphosphate disodium salt
- Summenformel
- C9H15N2NaO12P2
- Molmasse
- 428.16
Namen und Synonyme
27821-45-0Uridine-5'-diphosphate disodium saltUDP disodium saltUridine 5'-(trihydrogen diphosphate), disodium saltDisodium uridine 5'-diphosphateCU84BH96WLURIDINE DIPHOSPHATE DISODIUM [WHO-DD]RefChem:589552URIDINE DIPHOSPHATE DISODIUM248-678-9EINECS 248-678-9URIDINE 5'-(TRIHYDROGEN DIPHOSPHATE), SODIUM SALT (1:2)
Weitere Namen anzeigen
Uridine-5-diphosphate disodiumUDP 2NAUDP.Na25′-UDP,2Na5'-UDP-Na25'-UDP 2Na HydrateDiquafosol Impurity 17Uridine 5’-diphosphateSodium 1-((2R,3R,4S,5R)
Uridine 5'-diphosphate disodium saltUridine 5'-diphosphate sodiumUridine 5'-diphosphoric acid disodium saltSCHEMBL1873401MFCD00084679HMS3263B12AKOS015893509CCG-222509
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- Polarare Oberfläche (TPSA)
- 218 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 12
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 27
- Formalladung
- 0
- Komplexität
- 665
Physikochemische Eigenschaften
- storage temp.
- -20 °C · -20°C
- Aggregatzustand
- Powder
- Farbe
- White to Off-white
- Biologische Quelle
- synthetic
- Wasserlöslichkeit
- Slightly soluble in water.
- BRN
- 8817400 · 8817400
- InChIKey
- KWDGQJWFEYTPBN-IBOJMDDDSA-L
- SMILES
- O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=CC(=O)NC1=O)O.[NaH] |&1:1,2,3,15,r|
- CAS Datenbank
- 27821 · 27821-45-0(CAS DataBase Reference)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Sicherheitsdaten
- F
- 10-21
- wgk
- 3
- hs_code
- 29349990
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2STOT SE 3
Chemie und Industrie
Anwendungen
BeschreibungUridine-5'-diphosphate disodium salt (UDP-Na2) is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). It is an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis. It has also been used as a purinergic agonist, in order to study its effect on the flux of absorbed cations in cochlear outer sulcus cells (OSC) and vestibular migratory cells (VTC). UDP-Na2 has also been used to determine the activity of nucleoside diphosphatase (NDPase) in the rabbit retina.
VerwendenUridine-5'-diphosphate disodium salt is mainly used in nucleic acid (RNA) biosynthesis and cell signalling studies. Uridine-5'-monophosphate disodium salt (UDP-MS) is a structural analogue of uridine and is used as a dietary supplement. It has been shown to inhibit phosphodiesterase and cyclic nucleotide phosphodiesterase, both of which are enzymes that degrade the secondary messenger cyclic adenosine monophosphate (cAMP).
VerwendenUridine-5'-diphosphate disodium salt (UDP-Na2) is an organometallic compound, It is a P2Y6 receptor agonist and GPR105 receptor inhibitor. It is used in studies on nucleic acid (RNA) biosynthesis and cell signaling. UDP is a nucleotide that upon phosphorylation to UTP becomes a substrate for enzymes such as RNA polymerase(s) and GTPases. These enzymes are involved in a wide range of applications from the synthesis of RNA to the regulation of G-coupled Protein Receptors (GPCR) and cell signaling molecules such as Rho-signaling via Guanine Nucleotide Exchange Factors (GEF).
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