Zoniporide hydrochloride
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Grundinformationen
- CAS
241800-97-5- Standard-SMILES
Cl.NC(N)=NC(=O)c1cnn(-c2cccc3ncccc23)c1C1CC1- InChIKey
JTEXNYIOROVPIR-UHFFFAOYSA-N- Summenformel
- C17H17ClN6O
- Durchschnittliche Molmasse
- 356,817 g/mol
- Monoisotopische Masse
- 356,11523684
Namen und Bezeichner
- Bevorzugter Name
- Zoniporide hydrochloride
- IUPAC
- 5-Cyclopropyl-N-(diaminomethylidene)-1-(quinolin-5-yl)-1H-pyrazole-4-carboxamide--hydrogen chloride (1/1)
- Englischer Name
- ZONIPORIDE DIHYDROCHLORIDE
- Summenformel
- C17H17ClN6O
- Molmasse
- 356.81
Namen und Synonyme
Zoniporide dihydrochZONIPORIDE DIHYDROCHLORIDE[1-(quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine hydrochloride[1-(QUINOLIN-5-YL)-5-CYCLOPROPYL-1H-PYRAZOLE-4-CARBONYL]GUANIDINE DIHYDROCHLORIDE5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide:hydrochloride
Datenbank-Bezeichner
- CAS
241800-97-5- PubChem CID
- 11962997
- DTXSID
DTXSID4058520- ChEMBL
CHEMBL5715927- UNII
- B2ZBB5T6KM
Eigenschaften
Physikochemische Eigenschaften
- storage temp.
- -20 °C · Desiccate at -20°C
- Löslichkeit
- 1 mg/ml · ≤1mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
- Aggregatzustand
- crystalline solid
- Stabilität
- Hygroscopic
Chemie und Industrie
Anwendungen
VerwendenThe sodium-hydrogen exchanger isoform-1 (NHE-1) is the most predominant isoform of the Na+/H+ exchanger and is expressed in the heart where it contributes to cardiomyocyte pH homeostasis. It plays an important role in the myocardial response to ischemia-reperfusion. Zoniporide inhibits human NHE-1 with an IC50 value of 14 nM, displaying greater than 150-fold selectivity over other NHE isoforms. It has been shown to reduce infarct size in a rabbit myocardial ischemia-reperfusion model without adversely affecting hemodynamics or cardiac function. In isolated heart, zoniporide reduced infarct size with an EC50 value of 0.25 nM.
Anbieter14 Anbieter
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
VDM Biochemicals0330-2528181 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
EMMX Biotechnology LLC888-539-0666 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
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