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HCID 119921Erstellt: 26. Oktober 2026

1,2,3,4-Tetrahydro-5-hydroxynaphthalin-1-on

5-hydroxy-3,4-dihydronaphthalen-1(2H)-one · 1-TETRALON-5-OL · 5-Hydroxy-1-tetraL · 5-HYDROY-1-TETRAIONE · 5-HYDROXY-1-TETRALONE · 5-Hydroxy-α-tetralone · 5-Hydroxy-1-tetrazole · Levobunolol Impurity 5

https://huagongshe.com/de/chemical/119921

Molekülstruktur von 1,2,3,4-Tetrahydro-5-hydroxynaphthalin-1-on

Identifikatoren & physikalische Daten

CAS No.28315-93-7
SummenformelC10H10O2
Durchschnittliche Molmasse162,18 g/mol
Monoisotopische Masse162,06807956 g/mol
SMILESO=C1CCCc2c(O)cccc21
InChIKeyYPPZCRZRQHFRBH-UHFFFAOYSA-N
PubChem CID119921
ChEMBLCHEMBL3561186
EC No.248-958-0
DTXSIDDTXSID0057700
Lokaler Name1,2,3,4-Tetrahydro-5-hydroxynaphthalin-1-on

Chemische & physikalische Eigenschaften

XLogP2,1
Polarare Oberfläche (TPSA)37,3
H-Brücken-Donoren1
H-Brücken-Akzeptoren2
Frei drehbare Bindungen0
Schwere Atome12
Formalladung0
Komplexität188
Schmelzpunkt206-209 °C (lit.)
Siedepunkt228.88°C (rough estimate)
Dichte1.0281 (rough estimate)
Brechungsindex1.5380 (estimate)
LagerbedingungenSealed in dry,Room Temperature
LöslichkeitSoluble in alcohol, ether, benzene and acetic acid.
AggregatzustandSolid
pKa (Säurekonstante)9.37±0.20(Predicted)
FarbeWhite to Off-White
BRN2437410
InChIInChI=1S/C10H10O2/c11-9-5-1-3-7-8(9)4-2-6-10(7)12/h1,3,5,11H,2,4,6H2
InChIKeyYPPZCRZRQHFRBH-UHFFFAOYSA-N
SMILESC1(=O)C2=C(C(O)=CC=C2)CCC1
CAS Datenbank28315-93-7(CAS DataBase Reference)
NIST chemische Informationen5-Hydroxy-1-tetralone(28315-93-7)

Sicherheit & Vorschriften

GHS-EinstufungThis chemical does not meet GHS hazard criteria for 14.3% (1 of 7) of reports.WarningH315 (85.7%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (85.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (71.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 7 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 1 of 7 reports by companies.There are 3 notifications provided by 6 of 7 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Regulatorische Informationen1(2H)-Naphthalenone, 3,4-dihydro-5-hydroxy-: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesSkin Irrit. 2 (85.7%)Eye Irrit. 2A (85.7%)STOT SE 3 (71.4%)
Wassergefährdungsklasse (WGK)3
Zollcode29145090
R-Sätze (R)36/37/38
GefahrensymboleXi
Sicherheitshinweise (S)22-24/25-37/39-26-36
GefahrenklasseIRRITANT
Lagerklasse11 - Combustible Solids

Anwendungen & Verwendung

Verwenden

5-Hydroxy-1-tetralone, is used as a metabolite of Levobunolol (L335000) and d-Bunolol (L335010). It is also used as a reagent for the determination of hexoses and oligosaccharides by a fluorescence technique. A reagent that is used for fluorescence determination of enzyme activity. Some of the other applications include as internal standard during HPLC determination of 4-hydroxymephenytoin (4-OH-M) in human urine, as fluorescent labeling reagent during micro detection of glycosphingolipid on TLC plates, in synthesis of 1,2,3,4-tetrahydro-5H-1-benzazepine-quinone derivatives, in synthesis of new chiral oxathiane.