Lorediplon
Grundinformationen
- CAS
917393-39-6- Standard-SMILES
CC(=O)N(C)c1cc(-c2ccnc3c(C(=O)c4cccs4)cnn23)ccc1F- InChIKey
NQPOCLFSADOXBR-UHFFFAOYSA-N- Summenformel
- C20H15FN4O2S
- Durchschnittliche Molmasse
- 394,4 g/mol
- Monoisotopische Masse
- 394,08997494
Überblick
an hypnotic
Namen und Bezeichner
- Bevorzugter Name
- Lorediplon
- IUPAC
- N-[2-fluoro-5-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-N-methylacetamide
- Englischer Name
- Lorediplon
- Summenformel
- C20H15FN4O2S
- Molmasse
- 394.42
Namen und Synonyme
Lorediplon917393-39-6VKU6Z23NSYAcetamide, N-(2-fluoro-5-(3-(2-thienylcarbonyl)pyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-methyl-N-(2-Fluoro-5-(3-(thiophene-2-carbonyl)pyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-methylacetamideN-[2-fluoro-5-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-N-methylacetamideDTXSID00238684N-{2-fluoro-5-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl}-N-methylacetamideN-(2-fluoro-5-(3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-N-methylacetamidelorediplonumRefChem:154102DTXCID50161175
Weitere Namen anzeigen
Lorediplon, 10 mM in DMSOThionorphine HydrochlorideAcetamide, N-[2-fluoro-5-[3-(2-thienylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-N-methyl-GABA Receptor,γ-Aminobutyric acid Receptor,inhibit,Inhibitor,Lorediplon,Gamma-aminobutyric acid Receptor
Lorediplon [INN]UNII-VKU6Z23NSYGF-015535-00Lorediplon?MFCD27987938LOREDIPLON [WHO-DD]orb1296263SCHEMBL1316601
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,8
- Polarare Oberfläche (TPSA)
- 95,8 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 28
- Formalladung
- 0
- Komplexität
- 609
Physikochemische Eigenschaften
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- 25 mg/ml; · DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 14 mg/ml
- Aggregatzustand
- A crystalline solid
- Farbe
- Light yellow to yellow
Chemie und Industrie
Anwendungen
BeschreibungLorediplon is a non-benzodiazepine belonging to pyrazolopyrimidine family isunderdevelopment for the management for insomnia. Lorediplon acts by modulationof the GABAgreceptor. Its long plasma half-life has the potential of hypnotic effect. Ithas the potential for maintenance of sleep and the sleep architecture. In the phase Ipharmacodynamic study,it showed better efficacy in quality and maintenance ofsleep as compared with zolpidem. It has been shown to be well tolerated, safe with noresidual effects as compared with other sedative-hypnotic. Currently, the drug has completed Phase ll clinical trial. Results indicated strongefficacy in sleep maintenance with an acceptable safety profile. It also seems topreserve natural sleep architecture.
VerwendenLorediplon is GABAA receptor modulator and is used in the treatment of insomnia.
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