HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Ethyl-1-butanamin
2-ETHYLBUTYLAMINE · 2-ethyl-butylamin · 2-ethyl-1-butanamin · 2-ETHYL-N-BUTYLAMINE · 1-amino-2-ethylbutane · 2-Ethylbutylamine,97% · 3-(aMinoMethyl)pentane · 1-Butanamine, 2-ethyl-
Identifikatoren & physikalische Daten
| CAS No. | 617-79-8 |
|---|---|
| Summenformel | C6H15N |
| Durchschnittliche Molmasse | 101,19 g/mol |
| Monoisotopische Masse | 101,12044948 g/mol |
| SMILES | CCC(CC)CN |
| InChIKey | MGWAGIQQTULHGU-UHFFFAOYSA-N |
| PubChem CID | 12049 |
| EC No. | 210-530-6 |
| DTXSID | DTXSID00210703 |
| Lokaler Name | 2-Ethyl-1-butanamin |
Chemische & physikalische Eigenschaften
| XLogP | 1,3 |
|---|---|
| Polarare Oberfläche (TPSA) | 26 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 1 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 7 |
| Formalladung | 0 |
| Komplexität | 31,2 |
| Stoffklassen | Nitrogen Compounds -> Amines, Aliphatic |
| Geruch | Amine odor |
| Dichte | 0.776 @ 20 °C/20 °C |
| Color/Form | Water-white liquid |
| Löslichkeit | Soluble in methyl and ethyl alcohols, ethyl ether, ethyl acetate, acetone, aromatic and aliphatic hydrocarbons, fixed oils, mineral oil, oleic and stearic acids.Chloroform (Sparingly), DMSO (Slightly)Soluble in water at 25°C 3.83E+04 mg/L. |
| Siedepunkt | 125 °C |
| Decomposition | When heated to decomposition it emits toxic fumes of nitroxides. |
| Dampfdichte | 3.49 (AIR= 1) |
| Dampfdruck | 15.0 [mmHg] |
| Physical Description | Colorless liquid with an amine odor[HSDB] Colorless liquid or low melting solidmp = 20-23 deg C[MSDSonline] |
| Other Experimental Properties | 1 MG/L= 242 PPM1 PPM= 4.14 MG/CU M |
| Schmelzpunkt | 20°C |
| Brechungsindex | 1.4100 |
| Flammpunkt | 14 °C |
| Lagerbedingungen | Flammables area |
| Aggregatzustand | liquid |
| pKa (Säurekonstante) | 10.75±0.10(Predicted) |
| Farbe | Colourless |
| Henry-Konstante | 1.8×10-1 mol/(m3Pa) at 25℃, Yaws (2003) |
| InChI | InChI=1S/C6H15N/c1-3-6(4-2)5-7/h6H,3-5,7H2,1-2H3 |
| InChIKey | MGWAGIQQTULHGU-UHFFFAOYSA-N |
| SMILES | C(N)C(CC)CC |
| CAS Datenbank | 617-79-8(CAS DataBase Reference) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH225 (66.7%): Highly Flammable liquid and vapor [Danger Flammable liquids]P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P321, P330, P337+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 6 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Brandpotenzial | A very dangerous fire hazard when exposed to heat or flame ... |
| Gefahrenübersicht | Flammable liquid[Hawley] A skin and severe eye irritant[SAX] External application to rabbit eyes scored 9 on a scale of 1-10 (10 being most severe) for degree of injury after 24 hoursEmergency treatment: Irritants[HSDB] A corrosive substance that can cause injury to the skin, eyes, and respiratory tractMay be absorbed through skinInhalation may result in chemical pneumonitis[MSDSonline] |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Skin, Eye, and Respiratory Irritations | A skin and severe eye irritant. |
| Hazardous Reactivities and Incompatibilities | ... Can react with oxidizing materials. |
| Brandbekämpfungsverfahren | To fight fire, use dry chemical, carbon dioxide, foam. |
| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
| Preventive Measures | SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.Keep away from heat and open flame. |
| Unerwünschte Wirkungen | Dermatotoxin - Skin burns. |
| Non-Human Toxicity Excerpts | 2-ETHYLBUTYLAMINE RATED 9 ON RABBIT EYES /ON SCALE OF 1-10 WITH ATTENTION TO DEGREE OF CORNEAL INJURY 24 HR AFTER EXTERNAL APPLICATION./INHALATION TOXICITY: RATS EXPOSED TO 2200 PPM FOR 4 HR RESULTED IN MORTALITY RATE OF 0/6. /FROM TABLE/SKIN IRRITATION TO RABBITS GRADED 6. 6= MORE NECROSIS FROM UNDILUTED, LESS THAN EDEMA FROM 10%. /FROM TABLE/ |
| Antidote and Emergency Treatment | Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush the eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic Bases/Amines and Related compounds/Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV of D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Monitor for signs of hypoglycemia (decreased LOC, tachycardia, pallor, dilated pupils, diaphoresis, and/or dextrose stick or glucometer readings below 50 mg/dL) and administer 50% dextrose if necessary. Draw blood sample before administration ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic Bases/Amines and Related compounds/ |
| Toxicity Data | LC50 (rat) = 500 ppm/4h |
| Non-Human Toxicity Values | LD50 Rat oral 310 mg/kgLC50 Rat ihl 500 ppm/ 4 hrLD50 Rabbit skin 2000 mg/kgLD50 Rat oral 0.39 g/kgLD50 Rabbit skin 2.00 ml/kg |
| Wassergefährdungsklasse (WGK) | WGK 3 |
| UN-Transportnummer | 2733 |
| Zollcode | 2921199990 |
| R-Sätze (R) | 34-20/21/22-11-36-22 |
| Gefahrensymbole | C-F,F,C,Xn |
| hazard_note | Flammable/Harmful/Corrosive |
| Sicherheitshinweise (S) | 45-36/37/39-26-16 |
| Gefahrenklasse | 3Acute Tox. 4 OralEye Irrit. 2 |
| Verpackungsgruppe | II |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrstoffdaten | 617-79-8(Hazardous Substances Data) |
Anwendungen & Verwendung
Verwenden
2-Ethylbutylamine is used in preparation of Amide-substituted Heterocyclic compounds for the treatment of conditions related to the modulation of IL-12, IL-23 and/or IFN-alpha.