HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
SK&F 81297
sk&f81297 · (±)-6-Chloro-PB · SKF 81297 hydrobromi · SKF 81297 HYDROBROMIDE · (+/-)-SKF-81297 HYDROBROMIDE · (±)-6-Chloro-PB hydrobromide · (+/-)-6-CHLORO-PB HYDROBROMIDE · (+-)-6-CHLORO-PB HYDROBROMIDE (+-)-SKF-8 1297, HCL
Identifikatoren & physikalische Daten
| CAS No. | 71636-61-8 |
|---|---|
| Summenformel | C16H16ClNO2 |
| Durchschnittliche Molmasse | 289,75 g/mol |
| Monoisotopische Masse | 289,08695643 g/mol |
| SMILES | Oc1cc2c(c(Cl)c1O)CCNCC2c1ccccc1 |
| InChIKey | GHWJEDJMOVUXEC-UHFFFAOYSA-N |
| PubChem CID | 1218 |
| ChEMBL | CHEMBL353335 |
| ChEBI | CHEBI:91517 |
| EC No. | 635-324-7 |
| DTXSID | DTXSID3043815 |
Chemische & physikalische Eigenschaften
| XLogP | 2,7 |
|---|---|
| Polarare Oberfläche (TPSA) | 52,5 |
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 20 |
| Formalladung | 0 |
| Komplexität | 322 |
| Lagerbedingungen | Desiccate at +4°C |
| Löslichkeit | H2O: 1.7 mg/mLH2O: 1.7mg/mLDMSO: >10mg/mLethanol: 6.3mg/mL |
| Aggregatzustand | solid |
| Farbe | gray |
| InChI | 1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20/h1-5,8,13,18-20H,6-7,9H21H |
| InChIKey | RMIJGBMRNYUZRG-UHFFFAOYSA-N |
| SMILES | Br[H].Oc1cc2C(CNCCc2c(Cl)c1O)c3ccccc3 |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| Wassergefährdungsklasse (WGK) | 3 |
| R-Sätze (R) | 36/37/38 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 22-26-36 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Eye Irrit. 2Skin Irrit. 2STOT SE 3 |
Anwendungen & Verwendung
Verwenden
(±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signalregulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats.