Hypromellose Acetate Succinate
Grundinformationen
- CAS
71138-97-1- Standard-SMILES
CC(=O)O.CC(O)CO.CO.O=C(O)CCC(=O)O- InChIKey
ZUAAPNNKRHMPKG-UHFFFAOYSA-N- Summenformel
- C10H22O9
- Durchschnittliche Molmasse
- 286,28 g/mol
Überblick
structure given in first source
Namen und Bezeichner
- Bevorzugter Name
- Hypromellose Acetate Succinate
- IUPAC
- acetic acid;butanedioic acid;methanol;propane-1,2-diol
- Englischer Name
- Hydroxypropyl methyl cellulose acetate succinate
- Summenformel
- C10H22O9
- Molmasse
- 0
Namen und Synonyme
Hypromellose acetate succinate71138-97-1UNII-24P2YXD2PWUNII-36BGF0E889hydroxypropylmethylcellulose acetate succinateUNII-6N003M473WHypromellose acetate succinate [NF]RefChem:147500HpmcasHypromellose ASLF; Affinisol HPMCAS 912GHydroxypropyl methylcellulose acetate succinateacetic acid;butanedioic acid;methanol;propane-1,2-diol
Weitere Namen anzeigen
acetic acid, methanol, propane-1,2-diol, succinic acidHPMCAS AS-MFacetic acid, methanolacidhydroxypropylmethylacidesterHypromellose Acetate Succinate(HPMCAS)Hypromellose Acetate Succinate (100 mg)Hypromellose Acetate Succinate (1335279)Acetate hydroxypropyl methylcellulose succinate
SCHEMBL15366423C10H22O9FH167007acetic acid;methanol;propane-1,2-diol;succinic acidCellulose,2-hydroxypropylmethylehter,acetatehydrogenbutanedioateCellulose, 2-hydroxypropyl methyl ether, acetate hydrogen butanedioate
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 173 Ų
- H-Brücken-Donoren
- 6
- H-Brücken-Akzeptoren
- 9
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 19
- Formalladung
- 0
- Komplexität
- 146
Physikochemische Eigenschaften
- Schmelzpunkt
- 203 °C · >203°C (dec.)
- storage temp.
- -20 °C · Hygroscopic, -20°C Freezer, Under inert atmosphere
- Löslichkeit
- Practically insoluble in ethanol (95%), hexane, unbuffered water, and xylene. On the addition of acetone, or a mixture of ethanol (95%) and dichloromethane (1 : 1), a clear or turbid viscous solution is produced. Hypromellose acetate succinate also forms a clear or turbid solution in buffers of pH greater than 4.5 with the rank order of solubility for the various grades increasing with the ratio of acetyl over succinoyl substitution. The exact pH value at which the polymer starts to swell and dissolve depends on the buffer type and ionic strength, although the rank order for the different grades is independent of the buffer used. No solvent has been found to completely dissolve hypromellose acetate succinate polymer; the resulting clear or turbid solutions significantly scatter light in both static and dynamic light scattering experiments, indicating that the polymer may exist as colloids or aggregates. The data is collated from the Shin-Etsu Chemical Co. Ltd and the research work of the authors (R Chen, BC Hancock, and RM Shanker).
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Stabilität
- Hygroscopic
- Major Application
- pharmaceutical
- Kosmetik-Inhaltsstoffe Funktionen
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 100% (25 of 25) of all reports.
Not Classified
Aggregated GHS information provided per 25 reports by companies from 1 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesNot Classified
Sicherheitsdaten
- wgk
- WGK 3
- hs_code
- 3912390000
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
VerwendenHypromellose Acetate Succinate HPMCAS;is a pharmaceutical compound comprising enzalutamide.
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Anbieter98 Anbieter
国药集团化学试剂有限公司86-21-63210123 · [email protected]
江西益众化工有限公司15307925109 15350027073 · [email protected]
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
湖北万得化工有限公司15377098680 15377098680 · [email protected]
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]
山东泰诚生物科技有限公司18769832557 18769832557 · [email protected]
湖北鑫杰成化工科技有限公司13554075426 · [email protected]
湖北盛明安化工有限公司13928406992 · [email protected]
山东海舟生物工程有限公司130-0567-0367 13006570367 · [email protected]
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