Propan-1,2-diyldiacetat

1.059 AT 20 °C/4 °C

Relative density (water = 1): 1.06

1.055-1.060 (20 °C)

VERY SOL IN WATER; SOL IN ETHYL ALCOHOL, ETHYL ETHER

1.00E+05 mg/L @ 25 °C (exp)

Solubility in water, g/100ml: 10 (good)

Very slightly soluble in water

Soluble (in ethanol)

190 °C AT 762 MM HG

190.00 to 191.00 °C. @ 760.00 mm Hg

190 °C

189-191 °C

0.57 [mmHg]

Vapor pressure, Pa at 20 °C: 30

This chemical does not meet GHS hazard criteria for 99.8% (2573 of 2579) of all reports.

Not Classified

Aggregated GHS information provided per 2579 reports by companies from 5 notifications to the ECHA C&L Inventory.

Chemical: 1,2-Propanediol, diacetate

1,2-Propanediol, 1,2-diacetate is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2-Propanediol, 1,2-diacetate are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 29-03-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14142

1,2-Propanediol, diacetate: Does not have an individual approval but may be used under an appropriate group standard

Emergency treatment: irritants; [HSDB] Mild irritant when tested on human skin; Causes general anesthesia in lethal-dose feeding studies of guinea pigs; [RTECS] Forms explosive mixtures with air; May cause chemical pneumonitis if aspirated; [ICSC] An irritant; [MSDSonline] See Propylene glycol.

No data.

Fresh air, rest.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

Rinse with plenty of water (remove contact lenses if easily possible).

Rinse mouth. Do NOT induce vomiting.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Remove all ignition sources. Ventilation. Collect leaking liquid in covered containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that 1,2-propylene glycol diacetate is expected to have very high mobility in soil(SRC). Volatilization of 1,2-propylene glycol diacetate from moist soil surfaces may be important(SRC) given an estimated Henry's Law constant of 1.4X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(3). 1,2-Propylene glycol diacetate is not expected to volatilize from dry soil surfaces based on an estimated vapor pressure of 0.58 mm Hg(SRC), determined from a fragment constant method(4). Biodegradation data for 1,2-propylene glycol diacetate are not available(SRC). However, ethylene glycol diacetate has been determined to biodegrade readily as measured in the Hach respirometric and OECD screening (die-away) tests using sewage inocula(5). Because 1,2-propylene glycol diacetate is similar in structure to ethylene glycol diacetate, it has the potential to readily biodegrade(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that 1,2-propylene glycol diacetate is not expected to adsorb to suspended solids and sediment in water(SRC). 1,2-Propylene glycol diacetate may volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 1.4X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated volatilization half-lives for a model river and model lake are 336 days and 2446 days, respectively(3,SRC). A base-catalyzed second-order hydrolysis rate constant of 3.5X10-1 L/mol-sec(SRC) was estimated using a structure estimation method(7); this corresponds to half-lives of 227 days and 23 days at pH values of 7 and 8, respectively(7,SRC). According to a classification scheme(5), an estimated BCF of 3.2(3,SRC), from an estimated log Kow of 0.82(6,SRC), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data for 1,2-propylene glycol diacetate are not available(SRC). However, ethylene glycol diacetate has been determined to biodegrade readily as measured in the Hach respirometric and OECD screening (die-away) tests using sewage inocula(8). Because 1,2-propylene glycol diacetate is similar in structure to ethylene glycol diacetate, it has the potential to readily biodegrade(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,2-propylene glycol diacetate, which has an estimated vapor pressure of 0.58 mm Hg at 25 °C(2,SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,2-propylene glycol diacetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2.7 days(3,SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for 1,2-propylene glycol diacetate can be estimated to be about 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1,2-propylene glycol diacetate is expected to have very high mobility in soil(SRC).

Biodegradation data for 1,2-propylene glycol diacetate are not available(SRC). However, ethylene glycol diacetate has been determined to biodegrade readily as measured in the Hach respirometric and OECD screening (die-away) tests using sewage inocula(1). Because 1,2-propylene glycol diacetate is similar in structure to ethylene glycol diacetate, it has the potential to biodegrade readily(SRC).

An estimated BCF of 3.2 was calculated for 1,2-propylene glycol diacetate(SRC), using an estimated log Kow of 0.82(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for 1,2-propylene glycol diacetate is estimated as 1.4X10-7 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 1,2-propylene glycol diacetate may volatilize from water surfaces(2,SRC). Based on this Henry's Law constant, the estimated volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 336 days(2,SRC). The estimated volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 2446 days(2,SRC). 1,2-Propylene glycol diacetate's Henry's Law constant(1,SRC) indicates that volatilization from moist soil surfaces may occur(SRC). 1,2-Propylene glycol diacetate is not expected to volatilize from dry soil surfaces based on an estimated vapor pressure of 0.58 mm Hg(SRC), determined from a fragment constant method(3).

The rate constant for the vapor-phase reaction of 1,2-propylene glycol diacetate with photochemically-produced hydroxyl radicals has been estimated as 5.9X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 2.7 days at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1,SRC). A base-catalyzed second-order hydrolysis rate constant of 3.5X10-1 L/mol-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 227 days and 23 days at pH values of 7 and 8, respectively(2,SRC).

1,2-Propylene glycol diacetate's use as a research chemical may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 0.58 mm Hg at 25 °C indicates 1,2-propylene glycol diacetate will exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,2-propylene glycol diacetate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 2.7 days. If released to soil, 1,2-propylene glycol diacetate is expected to have very high mobility based upon an estimated Koc of 10. Volatilization from moist soil surfaces may be an important fate process based upon an estimated Henry's Law constant of 1.4X10-7 atm-cu m/mole. Volatilization from dry soil surfaces should not be important given the vapor pressure of this compound. If released into water, 1,2-propylene glycol diacetate is not expected to adsorb to suspended solids and sediment in water based on the estimated Koc. Volatilization from water surfaces may be an important fate process based on its estimated Henry's Law constant. Estimated half-lives from a model river and model lake are 336 days and 2446 days, respectively. Biodegradation data for 1,2-propylene glycol diacetate is not available. However, ethylene glycol diacetate has been determined to biodegrade readily as measured in the Hach respirometric and OECD screening (die-away) tests using sewage inocula. Because 1,2-propylene glycol diacetate is similar in structure to ethylene glycol diacetate, it has the potential to readily biodegrade. An estimated BCF of 3.2 suggests the potential for bioconcentration in aquatic organisms is low. A base-catalyzed second-order hydrolysis rate constant of 3.5X10-1 L/mol-sec was estimated using a structure estimation method; this corresponds to half-lives of 227 days and 23 days at pH values of 7 and 8, respectively. (SRC)

Used as a research chemical; [HSDB] Used as a solvent for coatings, silkscreen printing inks, and resins; Also used as an emulsifier food additive, a plasticizer for cellulosics, and a coalescing agent for paints; [CHEMINFO]

Painting (Solvents) [Category: Paint]

RESEARCH CHEMICAL

2023: <75,000 lb

(1979) NO EVIDENCE OF COMMERCIAL PRODN IN U.S.

(1981) NO EVIDENCE OF COMMERCIAL PRODN IN U.S.

EPA Safer Chemical Functional Use Classes -> Solvents

Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavoring Agents -> JECFA Flavorings Index

Textiles, apparel, and leather manufacturing

1,2-Propanediol, 1,2-diacetate: ACTIVE