5-Fam

HCID 123755

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Grundinformationen

CAS: 76823-03-5
Standard-SMILES: O=C(O)c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21
InChIKey: NJYVEMPWNAYQQN-UHFFFAOYSA-N
Summenformel: C21H12O7
Durchschnittliche Molmasse: 376,3 g/mol
Monoisotopische Masse: 376,05830272

Überblick

5-carboxyfluorescein is a monocarboxylic acid. It has a role as a fluorochrome. It is functionally related to a fluorescein (lactone form).

Namen und Bezeichner

Bevorzugter Name: 5-Fam
IUPAC: 3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid
Englischer Name: 5-Carboxyfluorescein
Summenformel: C21H12O7
Molmasse: 376.32

Namen und Synonyme

5-Carboxyfluorescein76823-03-55-FAM4-carboxyfluorescein4(5)-CarboxyfluoresceinDTXSID30227642AB2MM66GSFCHEBI:51617Spiro(isobenzofuran-1(3H),9'-(9H)xanthene)-5-carboxylic acid, 3',6-dihydroxy-3-oxo-RefChem:534189DTXCID801501333',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid

Weitere Namen anzeigen

5(6)-FAM5-CF5-Carboxyfluorescein (5-FAM)5-(AND-6)-CARBOXY SNARF(R)-1TQSY001Fam (dye)

3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acidMFCD000368743',6'-dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acidAS-32304PD0122133',6'-Dihydroxy-3-oxo-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acidQ271226875-Carboxyfluorescein (Technical Grade)

Datenbank-Bezeichner

CAS: 76823-03-5
PubChem CID: 123755
DTXSID: DTXSID30227642
ChEMBL: CHEMBL1614945
ChEBI: CHEBI:51617
UNII: AB2MM66GSF
EC Number: 691-482-7
Nikkaji: J480.059A

Eigenschaften

Berechnete Struktureigenschaften

XLogP: 2,9
Polarare Oberfläche (TPSA): 113 Å²
H-Brücken-Donoren: 3
H-Brücken-Akzeptoren: 7
Frei drehbare Bindungen: 1
Schwere Atome: 28
Formalladung: 0
Komplexität: 637

Physikochemische Eigenschaften

Schmelzpunkt: 368 · 368-372°C
Siedepunkt: 725.2 · 725.2±60.0 °C(Predicted)
Dichte: 1.73 · 1.73±0.1 g/cm3(Predicted)
storage temp.: 2 · Keep in dark place,Sealed in dry,2-8°C
Löslichkeit: DMF: soluble
pka: 3.3 · 3.3, 4.6, 6.4, 7.0(at 25℃)
Aggregatzustand: Solid
Farbe: Yellow to orange
BRN: 57037 · 57037
Major Application: Fluorescent probe, diagnosis of cancer, leukemia, colorectal cancer, polynucleotide, bacteria, pathogens, nucleic acid, hepatitis A virus, dengue virus, herpes simplex virus, gene, HIV type, cardiovascular risk factor
InChI: 1S/C21H12O7/c22-11-2-5-15-17(8-11)27-18-9-12(23)3-6-16(18)21(15)14-4-1-10(19(24)25)7-13(14)20(26)28-21/h1-9,22-23H,(H,24,25)
InChIKey: NJYVEMPWNAYQQN-UHFFFAOYSA-N
SMILES: OC(=O)c1ccc2c(c1)C(=O)OC23c4ccc(O)cc4Oc5cc(O)ccc35
CAS Datenbank: 76823 · 76823-03-5(CAS DataBase Reference)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Warning

H315 (20%): Causes skin irritation [Warning Skin corrosion/irritation]

P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)

Aggregated GHS information provided per 5 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Hazard Classes and CategoriesSkin Irrit. 2 (20%)

Sicherheitsdaten

F: 8
wgk: 3
hs_code: 32129000
risk_code: 36
hazard_code: Xi
safety_code: 26-39
Speicherklasse: 11 - Combustible Solids

Chemie und Industrie

Anwendungen · 2 Einträge

Beschreibung5-Carboxyfluorescein is a single isomer derivative of 5(6)-carboxyfluorescein that can be used to fluorescently label biomolecules through the interaction of carboxylic acid with primary amines. It demonstrates excitation/emission maxima of 492 and 518 nm, respectively.

Verwenden5-Carboxyfluorescein(5-FAM) contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid. It is a useful reagent for the preparation of hydrolytically stable fluorescent conjugates and is a useful starting material for the synthesis of other fluorescein-derives reagent. It has been principally used to develop a variety of green fluorescent reagents and small fluorescent molecules due to its relatively high absorbance characteristics, excellent fluorescence quantum yield, and good water solubility. The probe has also found application in studies of liposome-cell, cell-cell, and liposome-liposome interactions and in related studies on lipid bilayer structures.

Vor- und nachgelagerte Produkte

Vorgelagerte Rohstoffe

5-CARBOXYFLUORESCEIN DIACETATE

Nachgelagerte Produkte

6-Carboxyfluorescein

Anbieter100 Anbieter

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

北京欧凯纳斯生化科技有限公司010-62651721 18610486005 · [email protected]

韶远科技（上海）有限公司021-50795510 4000665055 · [email protected]

Ergänzende Hinweise

DefinitionChEBI: 5-carboxyfluorescein is a monocarboxylic acid. It has a role as a fluorochrome. It is functionally related to a fluorescein (lactone form).