Tauroursodeoxycholic acid
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Grundinformationen
- CAS
14605-22-2- Standard-SMILES
C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)CC4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C- Summenformel
- C26H45NO6S
- Durchschnittliche Molmasse
- 499,7 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Tauroursodeoxycholic acid
- Englischer Name
- Tauroursodeoxycholic acid
- Summenformel
- C26H45NO6S
- Molmasse
- 499.7
Namen und Synonyme
TUDCAUrsodoxicoltaurineTauroursodeoxycholic Acid (TUDCA)Tauroursodeoxycholate acidTauroursodeoxycholic Acid DihydrateTauroliteursodeoxycholyltaurineTauroursodeoxycholic acid-D4TUDCA Tauroursodeoxycholic Acidtauroursodeoxycholic acid sodium
Datenbank-Bezeichner
- CAS
14605-22-2- PubChem CID
- 12443252
- ChEMBL
CHEMBL4747140
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 173 · 173-175°C
- Dichte
- 1.216 · 1.216±0.06 g/cm3(Predicted)
- Brechungsindex
- 46 ° · 46 ° (C=1, EtOH)
- storage temp.
- 15 · 15-25℃
- Löslichkeit
- Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml with warming)
- Aggregatzustand
- solid
- pka
- 1.42 · 1.42±0.50(Predicted)
- Farbe
- White
- Stabilität
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
- Major Application
- lipidomics
- InChIKey
- BHTRKEVKTKCXOH-LBSADWJPSA-N
- SMILES
- [C@@]12([H])CC[C@H]([C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@@]1(C)CC[C@]1([H])[C@@]3(C)CC[C@@H](O)C[C@@]3([H])C[C@H](O)[C@@]21[H] |&1:0,4,5,18,22,24,28,31,34,36,r|
- CAS Datenbank
- 14605 · 14605-22-2(CAS DataBase Reference)
- CAS Number Unlabeled
- 35807 · 35807-85-3
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 2
- hs_code
- 29242990
- RTECS-Nr.
- KI7372500
- Toxizität
- mouse,LD50,intravenous,350mg/kg (350mg/kg),Japanese Kokai Tokyo Koho Patents. Vol. #92-235918,
- safety_code
- 22-24/25
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
BeschreibungTauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid synthesized in hepatocytes by the conjugation of ursodeoxycholic acid (UDCA) with the amino acid taurine. UDCA, which is made by gut bacteria, is FDAapproved in the United States for the treatment of certain cholestatic liver diseases. Humans make TUDCA to some extent, but it is found in copious amounts in the bile of bears. TUDCA is a classic inhibitor of endoplasmic reticulum (ER) stress. Reduces ER stress and adipose tissue inflammation in a mouse model of high fat diet-induced obesity. Blocks ER stress-induced NLRP3 inflammasome activation and hepatocyte death. Attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mouse model.
VerwendenTauroursodeoxycholic acid (TUDCA) is a water-soluble bile salt naturally occurring in the body. When bile salts reach the intestines, they can be metabolized by bacteria into ursodeoxycholic acid (UDCA). TUDCA is formed when taurine binds to UDCA. TUDCA is used to treat cholestasis, a condition in which bile fails to flow from the liver to the duodenum. TUDCA, UDCA, and other soluble bile salts can counteract the toxicity of regular bile acids when the latter are backed up in the liver. TUDCA is also used to treat cholesterol gallstones, dissolving them to a size in which they may be passed.
Anbieter100 Anbieter
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
北京绿百草科技发展有限公司
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