3-hydroxyphenazepam
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Grundinformationen
- CAS
70030-11-4- Standard-SMILES
O=C1Nc2ccc(Br)cc2C(c2ccccc2Cl)=NC1O- InChIKey
KRJKJUWAZOWXNV-UHFFFAOYSA-N- Summenformel
- C15H10BrClN2O2
- Durchschnittliche Molmasse
- 365,61 g/mol
Namen und Bezeichner
- Bevorzugter Name
- 3-hydroxyphenazepam
- Englischer Name
- 3-hydroxyphenazepam
- Summenformel
- C15H10BrClN2O2
- Molmasse
- 365.61
Namen und Synonyme
3-hydroxyphenazepam3-Hydroxyphenazepam CAS NO.70030-11-43-Hydroxyphenazepam 1.0 mg/ml in Methanol7-bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one2H-1,4-Benzodiazepin-2-one, 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-
Datenbank-Bezeichner
- CAS
70030-11-4- PubChem CID
- 125820
- ChEMBL
CHEMBL1449427- UNII
- 1KJ8MP77JK
- Nikkaji
- J1.074.642F
Eigenschaften
Physikochemische Eigenschaften
- Siedepunkt
- 544.5 · 544.5±50.0 °C(Predicted)
- Dichte
- 1.7 · 1.70±0.1 g/cm3(Predicted)
- storage temp.
- refrigerate for prolonged storage
- Löslichkeit
- 15 mg/ml; · DMF: 15 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 0.2 mg/ml
- Aggregatzustand
- A neat solid
- pka
- 10.8 · 10.80±0.70(Predicted)
- Farbe
- White powder
Chemie und Industrie
Anwendungen
Beschreibung3-Hydroxyphenazepam is an active metabolite of the novel psychoactive benzodiazepine phenazepam, which emerged in online drug markets in late 2011. Despite being a controlled substance in Europe, North America, and many countries in Asia, phenazepam has been encountered in the form of LSD mimic blotters and as counterfeit diazepam. This certified Snap-N-Spike(R) solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing.
Verwenden3-Hydroxyphenazepam, a metabolite of phenazepam, is also a GABAA receptor agonist. It has diminished myorelaxant properties, but is about equivalent in most other regards.Like other benzodiazepines, 3-hydroxyphenazepam behaves as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor with an EC50 value of 10.3 nM. 3-hydroxyphenazepam is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety.
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