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HCID 12734Erstellt: 27. Oktober 2026

N,N'-Methantetraylbis(1-methylethylamin)

DIC · Diisopropylcarbodiimide · DIPC · DIED · DIPCI · N,N-DIISOPROPYLCARBODIIMIDE · DIPCDI · 1,3-DIISOPROPYLCARBODIIMIDE

https://huagongshe.com/de/chemical/12734

Molekülstruktur von N,N'-Methantetraylbis(1-methylethylamin)

Identifikatoren & physikalische Daten

CAS No.693-13-0
SummenformelC7H14N2
Durchschnittliche Molmasse126,2 g/mol
Monoisotopische Masse126,11569845 g/mol
SMILESCC(C)N=C=NC(C)C
InChIKeyBDNKZNFMNDZQMI-UHFFFAOYSA-N
PubChem CID12734
ChEMBLCHEMBL1332992
ChEBICHEBI:53092
EC No.211-743-7
DTXSIDDTXSID4025086
Lokaler NameN,N'-Methantetraylbis(1-methylethylamin)

Chemische & physikalische Eigenschaften

XLogP2,6
Polarare Oberfläche (TPSA)24,7
H-Brücken-Donoren0
H-Brücken-Akzeptoren2
Frei drehbare Bindungen2
Schwere Atome9
Formalladung0
Komplexität101
StoffklassenNitrogen Compounds -> Other Nitrogen Compounds
SpringerMaterials PropertiesSurface tension
Dichte0.806 g/cu cm at 25 °C0.815 g/mL at 20 °C(lit.)
Color/FormColorless liquid
LöslichkeitSoluble in chloroform, methylene chloride, acetonitrile, dioxane, dimethylformamide, and tetrahydrofuranSoluble in chloroform, methylene chloride, acetonitrile, dioxane, dimethylformamide andtetrahydrofuran.
Siedepunkt147 °C145-148 °C(lit.)
DecompositionWhen heated to decomposition it emits toxic fumes of /oxides of nitrogen/.
Dampfdruck9.79 [mmHg]5.1 mm Hg at 25 °C34.9hPa at 55.46℃
BrechungsindexIndex of Refraction = 1.4320 at 20 °Cn20/D 1.433(lit.)
Physical DescriptionColorless liquid[Merck Index]
Other Experimental PropertiesFlammableReacts with water to form 1,3-diisopropylurea
Schmelzpunkt210-2120C (dec)
Flammpunkt93 °F
LagerbedingungenStore below +30°C.
AggregatzustandLiquid
FarbeClear colorless to yellow
BRN878281
Henry-Konstante9.9×10-3 mol/(m3Pa) at 25℃, HSDB (2015)
StabilitätVolatile
Hauptanwendungenpeptide synthesis
InChI1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
InChIKeyBDNKZNFMNDZQMI-UHFFFAOYSA-N
SMILESCC(C)N=C=NC(C)C
LogP (Verteilungskoeffizient)4.11 at 20℃
CAS Datenbank693-13-0(CAS DataBase Reference)
NIST chemische Informationen2-Propanamine, N,N'-methanetetraylbis-(693-13-0)
EPA chemische Informationen2-Propanamine, N,N'-methanetetraylbis- (693-13-0)

Sicherheit & Vorschriften

GHS-EinstufungDangerH226 (100%): Flammable liquid and vapor [Warning Flammable liquids]P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P271, P272, P273, P280, P284, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P320, P321, P332+P317, P333+P317, P342+P316, P362+P364, P370+P378, P391, P403, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 217 reports by companies from 25 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]
Regulatorische InformationenStatus: Active Update: 13-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/220471,3-Diisopropylcarbodiimide: Does not have an individual approval but may be used under an appropriate group standard
GefahrenübersichtAn irritantMay cause skin and respiratory sensitization[Merck Index] No evidence of carcinogenicity in dermal studies of mice and ratsClinical and histological evidence of neurotoxicity observed in male rats[NTP] A mild skin irritantCauses cutaneous sensitization, convulsions, coma, lachrymation, ataxia, changes in thymus and kidney weights, weight loss, spermatogenesis, and allergic dermatitis in repeated-dose dermal studies of mice[RTECS] Reacts with water producing 1,3-diisopropylurea[HSDB] An irritant that may cause serious eye injuryHighly toxic by inhalation[Alfa Aesar MSDS]
Hazard Classes and CategoriesFlam. Liq. 3 (100%)Flammable liquids - Category 3Serious eye damage/eye irritation - Category 1
EntsorgungsverfahrenSRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality

Anwendungen & Verwendung

Beschreibung

Diisopropylcarbodiimide (DIC) is a clear liquid that can be easily dispensed by volume. It slowly reacts with moisture from the air, so for long term storage the bottle should be flushed with dry air or inert gas and sealed tightly. It is used in peptide chemistry as a coupling reagent. It is very toxic and caused contact dermatitis in a laboratory worker.

Verwenden

N,N'-Diisopropylcarbodiimide is used as a reagent in synthetic organic chemistry. It serves as a chemical intermediate and as a stabilizer for Sarin (chemical weapon). It is also used in the synthesis of peptide and nucleic acid. Further, it is used as an antineoplastic and involved in the treatment of malignant melanoma and sarcomas. It is mainly used in amikacin, glutathione dehydrants, as well as in synthesis of acid anhydride, aldehyde, ketone, isocyanate; when it is used as dehydrating condensing agent, it reacts to dicyclohexylurea through short-time reaction under normal temperature.

potential migration in soil or water
effects on animal and plant life
and conformance with environmental and public health regulations.
UmweltverhaltenTERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 560(SRC), determined from a structure estimation method(2), indicates that 1,3-diisopropylcarbodiimide is expected to have low mobility in soil(SRC). However, 1,3-diisopropylcarbodiimide reacts with water(3)in moist soils, dicyclohexylcarbodiimide can hydrate to form diisopropylurea which has an estimated Koc of about 30(2,SRC) indicating high mobility in soil(1) for this degradation product(SRC). Volatilization of 1,3-diisopropylcarbodiimide from moist soil surfaces is expected to occur given an estimated Henry's Law constant of 9.92X10-4 atm-cu m/mole(SRC), using a fragment constant estimation method(2). 1,3-Diisopropylcarbodiimide is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 5.1 mm Hg at 25 °C(3).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 560(SRC), determined from a structure estimation method(2), indicates that 1,3-diisopropylcarbodiimide is expected to adsorb to suspended solids and sediment(SRC). However, 1,3-diisopropylcarbodiimide reacts with water to form diisopropylurea(3). Therefore, adsorption to sediment is not expected to be an important fate processes(SRC). 1,3-Diisopropylcarbodiimide hydration with water is a pseudo-first reaction and is both acid and base catalyzed(3)depending upon conditions (pH, buffering agents, etc), the hydration half-life may vary from less than one hour to several days(3,SRC). At slow hydration rates, some volatilization from water may occur(SRC) based upon an estimated Henry's Law constant of 9.92X10-4 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 4 hours and 5 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 240(SRC), from an estimated log Kow of 4.11(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is high(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,3-diisopropylcarbodiimide, which has a vapor pressure of 5.1 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,3-diisopropylcarbodiimide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 3.5 days(SRC), calculated from its rate constant of 4.55X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 1,3-Diisopropylcarbodiimide reacts with water(2)therefore, removal from air may occur through contact with water vapor or precipitation(SRC).
Unerwünschte WirkungenNeurotoxin - Other CNS neurotoxin
ToxizitätsübersichtA 2025 retrospective study about accidental exposures to diisopropylcarbodiimide described three male workers who experienced similar dermal, respiratory, and neurological effects. They were exposed by inhalation and dermal contact via a presumed single high level exposure from a leaking barrel. All three workers developed contact dermatitis, occupational asthma, neurological effects (persistent headaches, neuropathic pain and hand/foot paraesthesia, fatigue and cognitive impairment), and sleep disturbances. The authors concluded that the close temporal association to a single exposure suggested a possible causal relationship when including inforamtion about neurological toxicity from animal studies.
Ongoing Test StatusThe following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of June 21, 2012: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=693-13-0]The current link is broken and the link and wording could be updated as follows: https://ntpsearch.niehs.nih.gov/?query=693-13-0 The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, e.g., the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. The most recent update for this chemical was in May, 2025 (Evaluation of Substances of Regulatory Interest Using Non-Animal Skin Sensitization Test Methods). Content available as of November 12, 2025.
Soil Adsorption/MobilityUsing a structure estimation method based on molecular connectivity indices(1), the Koc of 1,3-diisopropylcarbodiimide can be estimated to be 560(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1,3-diisopropylcarbodiimide is expected to have low mobility in soil. 1,3-Diisopropylcarbodiimide hydrates in water(3)in moist soils, 1,3-diisopropylcarbodiimide can hydrate to form diisopropylurea which has an estimated Koc of about 30(1) indicating very high mobility in soil for the hydration product(2).
Artificial Pollution Sources1,3-Diisopropylcarbodiimide's production and use as a reagent for peptide syntheses, chemical intermediate, and stabilizer for military nerve agents(1) may result in its release to the environment through various waste streams.
Carcinogen ClassificationDiisopropylcarbodiimideTR-523: Toxicology and Carcinogenesis Studies of Diisopropylcarbodiimide (CASRN 693-13-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies) (2007 )09/28/05No Evidence
Environmental BioconcentrationAn estimated BCF of 240 was calculated in fish for 1,3-diisopropylcarbodiimide(SRC), using an estimated log Kow of 4.11(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC), provided the compound is not metabolized by the organism(SRC). 1,3-Diisopropylcarbodiimide hydrolyzes (hydrates) in water to form diisopropylurea(3), therefore, bioconcentration in aquatic organisms is not expected to be an important fate process(SRC).
Volatilization from Water/SoilThe Henry's Law constant for 1,3-diisopropylcarbodiimide is estimated as 9.92X10-4 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 1,3-diisopropylcarbodiimide is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 4 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 5 days(SRC). The importance of volatilization from water will be lessened because 1,3-Diisopropylcarbodiimide hydrolyzes (hydrates) in water to form diisopropylurea(3) with a half-life that may vary from less than one hour to several days(SRC). 1,3-Diisopropylcarbodiimide's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). 1,3-Diisopropylcarbodiimide is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 5.1 mm Hg at 25 °C(3).
Non-Human Toxicity Excerpts/LABORATORY ANIMALS: Acute Exposure/ ...The objectives of this study were to determine the irritation and sensitizing potential of these two compounds when applied topically to B6C3F1 mice. Sensitization potential was assessed by the Mouse Ear Swelling Test (MEST) and the murine Local Lymph Node Assay (LLNA). Concentrations used in the contact hypersensitivity assays were determined by primary irritancy studies. DCC and DIC were identified as both irritants and contact sensitizers with the MEST being a more sensitive indicator of sensitization potential. The MEST identified DCC as a sensitizer at concentrations as low as 0.006% (w/v) 24 hr and 48 hr post challenge and DIC at 0.3% (w/v) and 1.5% (w/v) 24 and 48 hr post challenge, respectively. In the LLNA, the lowest concentrations yielding a significant response were 0.06% (w/v) for DCC and 10% (w/v) for DIC./LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Dermal administration of DCC and DIC in F344/N rats and B6C3F1 mice for 90-days induced skin irritation at the site of application in a dose-dependent manner. Microscopically, dose-dependent increases in epidermal hyperplasia and chronic inflammation were observed. We further evaluated the effects of dermal exposure of DCC and DIC in p53 haploinsufficient and Tg.AC mouse models. Results revealed the skin as the primary target of DCC and DIC exposure as indicated by dose ? dependent skin lesions (hyperplasia, inflammation and necrosis). DCC induced squamous cell papillomas in Tg.AC mice but did not induce any neoplastic lesions in p53 haploinsufficient mice. Dermal application of DIC did not induce any neoplastic lesions in Tg.AC mice and p53 haploinsufficient mice. Based on these studies, it was predicted that DIC would be negative and DCC positive for carcinogenic activity in the traditional two-year bioassay. In the subsequent studies, the carcinogenic potential of DIC only in F344 rats and B6C3F1 mice in a traditional 2-year chronic carcinogenicity bioassay was evaluated by the dermal route. Findings revealed the skin as the major target organ of toxicity in both sexes in rats and in male mice. There were no neoplastic lesions observed in rats or mice with the administration of DIC. In rats, there were clinical signs of toxicity in the highest dose-group which included ataxia, excitability, impaired gait, low muscle tone, abnormal breathing, lethargy, and seizures. This was accompanied by non-neoplastic lesions in the brain and lung only at the highest dose level. In conclusion, both DIC and DCC are dermal toxicants. DIC did not have any carcinogenic activity in transgenic mouse models or in the traditional NTP two-year carcinogenicity studies in F344 rats and B6C3F1 mice. DCC was positive in the Tg.AC mouse model./GENOTOXICITY/ ... Analysis of peripheral blood smears from male and female B6C3F1 mice exposed to 17.5-140.0 mg DIC/kg/day by skin painting for 13 weeks revealed dose-related increases in the frequency of micronucleated normochromatic erythrocytes (MN-NCE) in both sexes. Results of a similar 13-week peripheral blood micronucleus (MN) test with DCC (1.5-12.0 mg/kg/day) were also positive, although the increases in MN-NCE were not as great as those observed with DIC. In contrast to the positive results of the subchronic skin-painting studies in mice, acute bone marrow MN studies with DIC and DCC in male F344 rats, using intraperitoneal (i.p.) injection, yielded negative results. Both the acute and the subchronic exposures included doses that produced clinical signs of toxicity. Acute mouse bone marrow MN tests with DIC administered in single or triple i.p. injection protocols were subsequently conducted to determine if the differing responses between mice and rats were due to species or protocol differences. The results of these acute tests were negative or equivocal. Because the subchronic studies produced positive results, it was hypothesized that these carbodiimides required multiple treatments over an extended period of time to produce an increase in MN-erythrocytes. To confirm the original response, a second dermal subchronic study was conducted with DICthe protocol was modified to include sequential blood samplings to permit monitoring MN frequencies over time. The data demonstrated a small but consistent induction of micronucleated erythrocytes in mice treated with DIC by skin painting.
Environmental Abiotic DegradationThe rate constant for the vapor-phase reaction of 1,3-diisopropylcarbodiimide with photochemically-produced hydroxyl radicals has been estimated as 4.55X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 3.5 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 1,3-Diisopropylcarbodiimide hydrolyzes (hydrates) in water to form diisopropylurea(2)the hydration is a pseudo-first reaction that is both acid and base catalyzed(2)depending upon conditions (pH, buffering agents, etc), the hydration half-life may vary from less than one hour to several days(SRC).
Probable Routes of Human ExposureOccupational exposure to 1,3-diisopropylcarbodiimide may occur primarily through dermal contact with this compound at workplaces where diisopropylcarbodiimide is produced or used, but exposure through inhalation of vapor can also occur(SRC). Human exposure to diisopropylcarbodiimide could occur during the extensive handling of the compound that occurs during the synthesis of peptides and other compounds in the chemical, pharmaceutical, and recombinant DNA industries(1).
F10-21
Wassergefährdungsklasse (WGK)3
TSCA-Inventar-StatusTSCA listed
UN-TransportnummerUN 2929 6.1/PG 1
Zollcode29252000
RTECS-Nr.FF2175000
R-Sätze (R)10-26-36/37/38-41-42/43-37/38
GefahrensymboleT+,T,F,Xn
hazard_noteFlammable/Highly Toxic/
Sicherheitshinweise (S)26-36/37/39-45-38-28A-16-22
Gefahrenklasse6.1Acute Tox. 1 InhalationEye Dam. 1Flam. Liq. 3Resp. Sens. 1Skin Sens. 1
VerpackungsgruppeII
Lagerklasse3 - Flammable liquids
Gefahrstoffdaten693-13-0(Hazardous Substances Data)