2-Cyanoethyl tetraisopropylphosphorodiamidite

HCID 128153CAS 102691-36-1
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Grundinformationen

Standard-SMILES
CC(C)N(C(C)C)P(OCCC#N)N(C(C)C)C(C)C
InChIKey
RKVHNYJPIXOHRW-UHFFFAOYSA-N
Summenformel
C15H32N3OP
Durchschnittliche Molmasse
301,41 g/mol
Monoisotopische Masse
301,22829927

Namen und Bezeichner

Bevorzugter Name
2-Cyanoethyl tetraisopropylphosphorodiamidite
IUPAC
3-bis[di(propan-2-yl)amino]phosphanyloxypropanenitrile
Englischer Name
2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite
Summenformel
C15H32N3OP
Molmasse
301.41

Namen und Synonyme

102691-36-1Cetipd2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphorodiamiditePhosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyanoethyl ester2-CYANOETHYL TETRAISOPROPYLPHOSPHORODIAMIDITEDTXSID8075176RefChem:862807DTXCID50327333-((Bis(diisopropylamino)phosphino)oxy)propanenitrileBis(diisopropylamino)(2-cyanoethoxy)phosphine2-CYANOETHYL N,N,N',N'-TETRAISOPROPYLPHOSPHORODIAMIDITEP-Reagent
Weitere Namen anzeigen
3-Bis(diisopropylamino)phosphanyloxypropanenitrileTHERAPEUTIC GRADE PHOS REAGENTTETRAISOPROPYLPHOSPHORODIAMIDITE94.0%(GC&
2-Cyanoethyl N,N,N',N'-tetraisopropylphosphordiamiditeMFCD00012213C15H32N3OPPhosphorodiamidous acid, N,N,N',N'-tetrakis(1-methylethyl)-, 2-cyanoethyl ester2-Cyanoethyl N,N,N',N'-Tetraisopropylphosphoramidite3-bis[di(propan-2-yl)amino]phosphanyloxypropanenitrile3-(bis(diisopropylamino)phosphinooxy)propanenitrile3-((Bis(diisopropylamino)phosphino)oxy)-propanenitrile

Datenbank-Bezeichner

CAS
102691-36-1
PubChem CID
128153
DTXSID
DTXSID8075176
UNII
8P2H5F3TEA
EC Number
600-337-9
Nikkaji
J738.473D

Eigenschaften

Berechnete Struktureigenschaften

XLogP
3,3
Polarare Oberfläche (TPSA)
39,5 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
4
Frei drehbare Bindungen
9
Schwere Atome
20

Physikochemische Eigenschaften

Siedepunkt
100 °C0.5 · 100 °C0.5 mm Hg(lit.)
Dichte
0.949 g/mL · 0.949 g/mL at 25 °C(lit.)
Brechungsindex
20 · n20/D 1.470(lit.)
Flammpunkt
141 °F · 141 °F
storage temp.
-20 °C · -20°C
Löslichkeit
Acetonitrile (Slightly), Benzene, Chloroform (Sparingly), Methanol (Slightly)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H226 (97.2%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P280, P284, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P321, P330, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P370+P378, P403, P403+P235, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 179 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory Information · 2 Einträge

Status: Active Update: 01-08-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/25176

Phosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyanoethyl ester: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesFlam. Liq. 3 (97.2%)

Sicherheitsdaten

F
10-21-34
wgk
3
ridadr
UN 1993 3/PG 3
hs_code
29299000
risk_code
5-36/37/38-42/43-36/38
hazard_code
Xi,Xn

Chemie und Industrie

Anwendungen · 2 Einträge

Beschreibung2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite is a colorless viscous liquid, which is soluble in most organic solvents. It is a widely used phosphitylating reagent for the preparation of various phosphorylated biomolecules, such as nucleoside carbohydrate conjugates, phospholipids and glycopeptides. In particular, this reagent is highly effective for automated solid-phase DNA/RNA oligonucleotide synthesis. It has shown great utility in the coupling of nucleobases or carbohydrates via their phosphotriesters in the presence of activators such as 1H-tetrazole, in moderate yields under mild conditions.This compound is cheaper and more stable than 2-cyanoethyl N,N-diisopropylchlorophosphorodiamidite (the other commonly used phosphinylating reagent)[1].

VerwendenReagent for synthesizing phosphitylated nucleotides.1

Vor- und nachgelagerte Produkte

Anbieter50 Anbieter

北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]
北京安司莫森技术有限公司010-82954736 13391601435 · [email protected]

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