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Chlordiphenylarsin

Diphenylchloroarsine

HCID 12836
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Grundinformationen

CAS
712-48-1
Standard-SMILES
Cl[As](c1ccccc1)c1ccccc1
InChIKey
YHHKGKCOLGRKKB-UHFFFAOYSA-N
Summenformel
C12H10AsCl
Durchschnittliche Molmasse
264,58 g/mol
Monoisotopische Masse
263,968698

Überblick

Diphenylchloroarsine appears as a chemical warfare vomiting agent. It is a colorless crystalline solid, or a dark-brown liquid. Strongly irritating to skin and eyes. Toxic by ingestion and inhalation.

Namen und Bezeichner

Bevorzugter Name
Diphenylchloroarsine
IUPAC
chloro(diphenyl)arsane
Lokaler Name
Chlordiphenylarsin
Englischer Name
Diphenyl chloroarsine
Summenformel
C12H10AsCl
Molmasse
264.58

Namen und Synonyme

DIPHENYLCHLOROARSINESneezing gasDiphenylchlorarsineChlorodiphenylarsineClark 1EINECS 211-921-4BRN 2937168UNII-1H39V3559BDTXSID30858733Diphenylchloroarsine, solid1H39V3559BDiphenylchloroarsine, liquid
Weitere Namen anzeigen
clark1clarkibluecrosssneezinggasdifenylchlorarsinchlor-difenylarsindiphenylchloorarsinearsine,chlorodiphenylChlorodiphenylarsenic
3-16-00-00944 (Beilstein Handbook Reference)UN 1699chlorodiphenylarsaneArsine, chlorodiphenyl-diphenyl arsine chlorideRefChem:134672Diphenyl arsinous chlorideDTXCID30809467

Datenbank-Bezeichner

CAS
712-48-1
PubChem CID
12836
DTXSID
DTXSID30858733
UNII
1H39V3559B
EC Number

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
0 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
0
Frei drehbare Bindungen
2
Schwere Atome
14
Formalladung
0
Komplexität
142

Experimentelle und physikochemische Eigenschaften

Chemical ClassesReactive agents - 1st degree
Density · 2 Einträge

Relative density (water = 1): 1.4 (45 °C)

1.333 @ 40°C

SolubilitySolubility in water, g/100ml: 0.2 (poor)
Decomposition333 °C
Melting Point · 2 Einträge

38-44 °C

44 °C

Vapor DensityRelative vapor density (air = 1): 9.15
Vapor Pressure · 2 Einträge

Vapor pressure, Pa at 20 °C: 0.06

0.00049 [mm Hg] @20 °C

Physical Description · 2 Einträge

Diphenylchloroarsine appears as a chemical warfare vomiting agent. It is a colorless crystalline solid, or a dark-brown liquid. Strongly irritating to skin and eyes. Toxic by ingestion and inhalation.

COLOURLESS CRYSTALS. TECHNICAL-GRADE PRODUCT: DARK BROWN LIQUID.

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

Gefahrenhinweise

Regulatory Information · 2 Einträge

Restricted substance: Chlorodiphenylarsine

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

DOT LabelPoison
Fire Hazards · 3 Einträge

For information on chemical warfare vomiting agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)

· Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

· Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Health Hazards · 3 Einträge

For information on chemical warfare vomiting agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)

· Highly toxic, may be fatal if inhaled, ingested or absorbed through skin.

· Highly toxic, may be fatal if inhaled, ingested or absorbed through skin.

DOT ID and Guide · 2 Einträge

3450 151

1699 151

Reactive GroupAcyl Halides, Sulfonyl Halides, and Chloroformates
EC ClassificationSymbol: T, N; R: 23/25-50/53; S: (1/2)-20/21-28-45-60-61; Note: A
UN ClassificationUN Hazard Class: 6.1; UN Pack Group: I
Reactivity AlertsStrong Reducing Agent
Reactivity Profile · 1 Eintrag

Chemie und Industrie

Pharmakologische Informationen

Metabolism/Metabolites · 1 Eintrag

Arsenic is absorbed mainly by inhalation or ingestion, as to a lesser extent, dermal exposure. It is then distributed throughout the body, where it is reduced into arsenite if necessary, then methylated into monomethylarsenic (MMA) and dimethylarsenic acid (DMA) by arsenite methyltransferase. Arsenic and its metabolites are primarily excreted in the urine. Arsenic is known to induce the metal-binding protein metallothionein, which decreases the toxic effects of arsenic and other metals by binding them and making them biologically inactive, as well as acting as an antioxidant. (L20)

Verwendung und Herstellung

UsesDiphenylchloroarsine belongs to the group of chemical warfare agents known as vomiting agents or sneeze gases. Due to its toxicity, it is nowadays considered obsolete. (L359)

Anbieter5 Anbieter

陕西缔都新材料有限公司81124267 17392282731 · [email protected]
南通合润生物科技有限公司18362409333 · [email protected]
Shaanxi Didu New Materials Co. Ltd+86-86-17392712779 +86-13289823923 · [email protected]
厦门盈融达化工有限公司+86-0592-6210733 · [email protected]
DAYANG CHEM (HANGZHOU) CO.,LTD+86-88938639 +86-17705817739 · [email protected]

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Notizen zur Verbindung

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Auf dieser SeiteGrundinformationenÜberblickNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
211-921-4
Nikkaji
J35.211J

Physikochemische Eigenschaften

Schmelzpunkt
44 °C · 44°C
Siedepunkt
337 °C · 337°C
Dichte
1.482 · 1.4820
Brechungsindex
1.6332 · 1.6332
Aggregatzustand
solid
Henry's Law Constant
6.1 · 6.1×101 mol/(m3Pa) at 25℃, Ebert et al. (2023)
EPA chemische Informationen
Diphenylchlorarsine (712-48-1)

DIPHENYLCHLOROARSINE is incompatible with strong oxidizing agents, amines, and alkalis. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Chemical DangersDecomposes on heating. This produces toxic fumes including arsenic and chlorine. Reacts with strong oxidants.
Packaging and LabellingUnbreakable packaging. Put breakable packaging into closed unbreakable container. Severe marine pollutant.

Sicherheit und Schutzausrüstung

Fire Fighting · 2 Einträge

For information on chemical warfare vomiting agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)

In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep drums, etc., cool by spraying with water.

First Aid Measures · 4 Einträge

Fresh air, rest. Half-upright position. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Refer for medical attention .

Accidental Release Measures · 4 Einträge

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

First Aid · 3 Einträge

For information on chemical warfare vomiting agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)

General First Aid:

General First Aid:

Safe StorageSeparated from strong oxidants. Keep in a well-ventilated room.
Exposure Control and Personal Protection · 2 Einträge

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear positive pressure self-contained breathing apparatus (SCBA).

Nonfire Spill ResponseFor information on chemical warfare vomiting agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)
Spillage Disposal · 1 Eintrag

Sweep spilled substance into covered containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Personal protection: chemical protection suit including self-contained breathing apparatus.

Isolation and Evacuation · 3 Einträge

For initial isolation and protective action distances for chemical warfare vomiting agents see the Chemical Warfare Agents table in the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)

Immediate precautionary measure

Immediate precautionary measure

Eye PreventionWear safety spectacles, face shield or eye protection in combination with breathing protection.
Inhalation RiskA harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C; on spraying or dispersing, however, much faster.
Skin PreventionProtective gloves.

Toxikologische Informationen

Treatment · 1 Eintrag

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

Health EffectsArsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20)
Exposure Routes · 2 Einträge

The substance can be absorbed into the body by inhalation of its aerosol.

Oral (L2) ; inhalation (L2) ; dermal (L2)

Toxicity Summary · 1 Eintrag

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

Signs and Symptoms · 5 Einträge

Sore throat. Cough. Headache. Nausea. Vomiting. Laboured breathing. Shortness of breath. Chest tightness. Unconsciousness. Symptoms may be delayed.

Redness.

Watering of the eyes. Redness.

Abdominal pain. Headache. Nausea. Vomiting.

Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of

ICSC Environmental DataThe substance is very toxic to aquatic organisms.
Carcinogen Classification3, not classifiable as to its carcinogenicity to humans. (L135)

Sicherheitsdaten

ridadr
UN 3450 6.1/PG I (DIPHENYLCHLOROARSINE, SOLID)
hazard_class
6.1(a)
packing_group
I