Dihexa
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Grundinformationen
- CAS
1401708-83-5- Standard-SMILES
CCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)NCCCCCC(N)=O)[C@@H](C)CC- InChIKey
XEUVNVNAVKZSPT-JTJYXVOQSA-N- Summenformel
- C27H44N4O5
- Durchschnittliche Molmasse
- 504,672 g/mol
- Monoisotopische Masse
- 504,33117051
Namen und Bezeichner
- Bevorzugter Name
- Dihexa
- Englischer Name
- Dihexa
- Summenformel
- C27H44N4O5
- Molmasse
- 504.66
Namen und Synonyme
Hexanoyl-Tyr-Ile-Ahx-NH2PNB-0408DihexaDihexa (PNB-0408)Prebiotic dipeptideDihexa, 10 mM in DMSODihexa (Synonyms: PNB-0408Dihexa（Hexanoyl-Tyr-Ile-Ahx-NH2）TIANFUCHEM--1401708-83-5---DihexaN-hexanoic-Tyr-Ile-(6) aminohexanoic amide
Datenbank-Bezeichner
- CAS
1401708-83-5- PubChem CID
- 129010512
- DTXSID
DTXSID701032895- UNII
- 9WYX65A5C2
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 209 °C · >209°C (dec.)
- Siedepunkt
- 866.2 · 866.2±65.0 °C(Predicted)
- Dichte
- 1.111 · 1.111±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 9.83 · 9.83±0.15(Predicted)
- Farbe
- White to Off-White
- InChIKey
- ADWKPLXLPNPJTR-JTJYXVOQSA-N
- SMILES
- C(N)(=O)[C@H]([C@@H](C)CC)N(C(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)CCCCC)CCCCCC(N)=O
Chemie und Industrie
Anwendungen
BeschreibungDihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.
VerwendenN-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa) is an angiotensin IV analog as a procognitive/antidementia agent.
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咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
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Baoji Guokang Healthchem co.,ltd
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