HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(N,N-didemethyl) 1-Hydroxy Sibutramine Hydrochloride
1-Hydroxy didesmethyl Sibutramine · (N,N-Didemethyl)-1-Hydroxy-Sibutramine HCl · (N,N-didemethyl) 1-Hydroxy Sibutramine Hydrochloride · (N,N-dideMethyl) 1-Hydroxy SibutraMine Hydrocholride · Sertraline Impurity 1 Monomer（Sertraline EP Impurity A Monomer）
Identifikatoren & physikalische Daten
| CAS No. | 186521-88-0 |
|---|---|
| Summenformel | C15H23Cl2NO |
| Durchschnittliche Molmasse | 304,3 g/mol |
| Monoisotopische Masse | 303,1156697 g/mol |
| SMILES | CC(CO)CC(N)C1(c2ccc(Cl)cc2)CCC1.Cl |
| InChIKey | HXIZALIKJURKFS-UHFFFAOYSA-N |
| PubChem CID | 129012000 |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 46,3 |
|---|---|
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 5 |
| Schwere Atome | 19 |
| Formalladung | 0 |
| Komplexität | 259 |
| Schmelzpunkt | >86°C (dec.) |
| Lagerbedingungen | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Löslichkeit | DMSO (Slightly), Methanol (Sparingly) |
| Aggregatzustand | Solid |
| Farbe | White to Off-White |
| Stabilität | Hygroscopic |
Anwendungen & Verwendung
Verwenden
De(N,N-dimethyl) 1-Hydroxy Sibutramine Hydrocholride is an intermediate in the synthesis of De(N,N,3-trimethyl) Sibutramine Hydrocholride (D298380), an analogue of Sibutramine (S422500), a serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure.