2,2,6,6-Tetramethylpiperidin
2,2,6,6-Tetramethylpiperidine
Grundinformationen
- CAS
768-66-1- Standard-SMILES
CC1(C)CCCC(C)(C)N1- InChIKey
RKMGAJGJIURJSJ-UHFFFAOYSA-N- Summenformel
- C9H19N
- Durchschnittliche Molmasse
- 141,25 g/mol
- Monoisotopische Masse
- 141,15174961
Namen und Bezeichner
- Bevorzugter Name
- 2,2,6,6-Tetramethylpiperidine
- IUPAC
- 2,2,6,6-tetramethylpiperidine
- Lokaler Name
- 2,2,6,6-Tetramethylpiperidin
- Englischer Name
- 2,2,6,6-Tetramethylpiperidine
- Summenformel
- C9H19N
- Molmasse
- 141.25
Namen und Synonyme
2,2,6,6-Tetramethylpiperidine768-66-1NorpempidinePIPERIDINE, 2,2,6,6-TETRAMETHYL-HTMP2,2,6,6-Tetramethylpeperidine2,2,6,6-TETRAMETHYL PIPERIDINEMFCD000059852,2,6,6-tetramethyl-piperidine44N9S1YCFM2,6,6-Tetramethylpiperidine2,2,6,6-teramethylpiperidine
Weitere Namen anzeigen
TETRAMETHYLPIPERIDINE2,2,6,6-TetramethyL2,2,6,6-Teteamethyl-piperidine6-TetraMethylpiperidine2,2,6,6-Tetramethylpiperidine(Tmp)2,2,62,2,6,6-TetramethylpMedetomidine Impurity 100
2,2,6,6-tetramethylpiperdine2,2,6,6-tetramethylpiperidin2,2,6,6-tetramethylpiperadineTNV 622NSC-102838EINECS 212-199-3UNII-44N9S1YCFMNSC 102838
Datenbank-Bezeichner
- CAS
768-66-1- PubChem CID
- 13035
- DTXSID
DTXSID0061113- ChEMBL
CHEMBL2448812- UNII
- 44N9S1YCFM
- EC Number
- 212-199-3
- Nikkaji
- J1.732I
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,1
- Polarare Oberfläche (TPSA)
- 12 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 1
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 10
- Formalladung
- 0
- Komplexität
- 111
Experimentelle und physikochemische Eigenschaften
Chemical ClassesNitrogen Compounds -> Amines, Cyclic
SpringerMaterials PropertiesChemical shift
LogP2.15
Vapor Pressure0.98 [mmHg]
Physical DescriptionLight yellow liquid; [Sigma-Aldrich MSDS]
Dissociation Constants11.1
Physikochemische Eigenschaften
- Schmelzpunkt
- -59 °C · -59°C
- Siedepunkt
- 152 °C · 152 °C (lit.)
- Dichte
- 0.837 g/mL · 0.837 g/mL at 25 °C (lit.)
- Dampfdruck
- 14 hPa · 14 hPa (39 °C)
- Brechungsindex
- 20 · n20/D 1.445(lit.)
- Flammpunkt
- 76 °F · 76 °F
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H226 (97.1%): Flammable liquid and vapor [Warning Flammable liquids]
P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 102 reports by companies from 23 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Chemical: Piperidine, 2,2,6,6-tetramethyl-
REACH registered substance: 2,2,6,6-tetramethylpiperidine (EC: 212-199-3)
2,2,6,6-Tetramethylpiperidine: Does not have an individual approval but may be used under an appropriate group standard
Hazards Summary
Rats demonstrated effects possibly indicative of neurotoxicity in all test groups of acute inhalation study and high dose group (500 mg/kg) of acute oral study; [EPA - TSCATS] A skin and strong eye irritant; Toxic by ingestion; [Sigma-Aldrich MSDS] See Piperidine.
Hazard Classes and CategoriesFlam. Liq. 3 (97.1%)
Toxikologische Informationen
Adverse EffectsNeurotoxin - Other CNS neurotoxin
Toxicity DataLC50 (rat) = 4,550 mg/m3/4hr
Chemie und Industrie
Verwendung und Herstellung
General Manufacturing InformationPiperidine, 2,2,6,6-tetramethyl-: ACTIVE
Anwendungen
Verwenden2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors.
Darstellung
synthetischeMany routes for the synthesis of TMP have been reported. One method starts with a conjugate addition reaction of ammonia to phorone. The intermediate triacetone amine is then reduced in a Wolff-Kishner reaction.
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