2,2,6,6-Tetramethylpiperidin

2,2,6,6-Tetramethylpiperidine

HCID 13035CAS 768-66-1
TeilstruktursucheÄhnliche Strukturen suchen

Grundinformationen

Standard-SMILES
CC1(C)CCCC(C)(C)N1
InChIKey
RKMGAJGJIURJSJ-UHFFFAOYSA-N
Summenformel
C9H19N
Durchschnittliche Molmasse
141,25 g/mol
Monoisotopische Masse
141,15174961

Namen und Bezeichner

Bevorzugter Name
2,2,6,6-Tetramethylpiperidine
IUPAC
2,2,6,6-tetramethylpiperidine
Lokaler Name
2,2,6,6-Tetramethylpiperidin
Englischer Name
2,2,6,6-Tetramethylpiperidine
Summenformel
C9H19N
Molmasse
141.25

Namen und Synonyme

2,2,6,6-Tetramethylpiperidine768-66-1NorpempidinePIPERIDINE, 2,2,6,6-TETRAMETHYL-2,2,6,6-TETRAMETHYL PIPERIDINEMFCD00005985HTMP2,2,6,6-tetramethyl-piperidine44N9S1YCFMNSC-1028382,2,6,6-TetramethylpeperidineEINECS 212-199-3
Weitere Namen anzeigen
TETRAMETHYLPIPERIDINE2,2,6,6-TetramethyL2,2,6,6-Teteamethyl-piperidine6-TetraMethylpiperidine2,2,6,6-Tetramethylpiperidine(Tmp)2,2,62,2,6,6-TetramethylpMedetomidine Impurity 100
UNII-44N9S1YCFMNSC 1028382,2,6,6 Tetramethyl piperidineNSC102838SCHEMBL151002,6,6-TetramethylpiperidineSCHEMBL146951SCHEMBL210605

Datenbank-Bezeichner

CAS
768-66-1
PubChem CID
13035
DTXSID
DTXSID0061113
ChEMBL
CHEMBL2448812
UNII
44N9S1YCFM
EC Number
212-199-3
Nikkaji
J1.732I

Eigenschaften

Berechnete Struktureigenschaften

XLogP
2,1
Polarare Oberfläche (TPSA)
12 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
1
Frei drehbare Bindungen
0
Schwere Atome
10

Experimentelle und physikochemische Eigenschaften

Chemical ClassesNitrogen Compounds -> Amines, Cyclic
SpringerMaterials PropertiesChemical shift
Vapor Pressure0.98 [mmHg]
Physical DescriptionLight yellow liquid; [Sigma-Aldrich MSDS]
Dissociation Constants11.1

Physikochemische Eigenschaften

Schmelzpunkt
-59 °C · -59°C
Siedepunkt
152 °C · 152 °C (lit.)
Dichte
0.837 g/mL · 0.837 g/mL at 25 °C (lit.)
Dampfdruck
14 hPa · 14 hPa (39 °C)
Brechungsindex
20 · n20/D 1.445(lit.)
Flammpunkt
76 °F · 76 °F

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H226 (97.1%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 102 reports by companies from 23 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory Information · 3 Einträge

Chemical: Piperidine, 2,2,6,6-tetramethyl-

Status: Active Update: 11-05-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/19475

2,2,6,6-Tetramethylpiperidine: Does not have an individual approval but may be used under an appropriate group standard

Hazards Summary · 1 Eintrag

Rats demonstrated effects possibly indicative of neurotoxicity in all test groups of acute inhalation study and high dose group (500 mg/kg) of acute oral study; [EPA - TSCATS] A skin and strong eye irritant; Toxic by ingestion; [Sigma-Aldrich MSDS] See Piperidine.

Hazard Classes and CategoriesFlam. Liq. 3 (97.1%)

Toxikologische Informationen

Adverse EffectsNeurotoxin - Other CNS neurotoxin
Toxicity DataLC50 (rat) = 4,550 mg/m3/4hr

Sicherheitsdaten

wgk
2
tsca
TSCA listed
ridadr
UN 1992 3/PG 3
hs_code
29333999
RTECS-Nr.
TN4220000
risk_code
10-22-36/37/38

Chemie und Industrie

Verwendung und Herstellung

General Manufacturing InformationPiperidine, 2,2,6,6-tetramethyl-: ACTIVE

Anwendungen

Verwenden2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors.

Darstellung

synthetischeMany routes for the synthesis of TMP have been reported. One method starts with a conjugate addition reaction of ammonia to phorone. The intermediate triacetone amine is then reduced in a Wolff-Kishner reaction.

Vor- und nachgelagerte Produkte

Nachgelagerte Produkte

Anbieter50 Anbieter

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]
爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

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