Fibronectin

BeschreibungFibronectin (FN) is a glycoprotein whose size ranges from 230 to 270 kDa and usually exists as a dimer, covalently linked by a pair of disulfide bonds at the C-termini. Each monomer consists of three repeating units: 12 Type I, 2 Type II, and 15–17 Type III domains, which account for 90% of the FN sequence. Structural homologs of the Type I, II, and III domains exist in other biomolecules, suggesting that FN evolved through exon shuffling. Despite originating from a single gene, as many as 20 different human variants and 12 different rodent and cow variant FN isoforms have been identified, indicating alternative splicing mechanisms unique to species and tissue development. FN is subcategorized as either plasma FN (pFN), predominantly synthesized by liver hepatocytes, or cellular FN (cFN), which is produced by a wide variety of cells, including fibroblasts, chondrocytes, myocytes, and synovial cells. pFN circulates in the blood at a high concentration (approximately 300 μg/mL), while cFN is locally secreted[1].

Verwendenfibronectin (hydrolyzed) is a humectant and moisturizing agent for skin creams and lotions.