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HCID 131007Erstellt: 2. November 2026

N-(20-Amino-4-hydroxy-4,8,12,17-tetraazaeicos-1-yl)-1H-indole-3-acetamide

AG 489 · Agatoxin489 · Agatoxin-489 · Agatoxin 489 · N-(20-Amino-4-hydroxy-4,8,12,17-tetraazaicosan-1-yl)-1H-indole-3-acetamide · N-(4-Hydroxy-20-amino-4,8,12,17-tetraazaicosane-1-yl)-1H-indole-3-acetamide · N-[3-[3-[3-[4-(3-Aminopropylamino)butylamino]propylamino]propylhydroxyamino]propyl]-1H-indole-3-acetamide

https://huagongshe.com/de/chemical/131007

Molekülstruktur von N-(20-Amino-4-hydroxy-4,8,12,17-tetraazaeicos-1-yl)-1H-indole-3-acetamide

Identifikatoren & physikalische Daten

CAS No.128549-96-2
SummenformelC26H47N7O2
Durchschnittliche Molmasse489,7 g/mol
Monoisotopische Masse489,37912377 g/mol
SMILESNCCCNCCCCNCCCNCCCN(O)CCCNC(=O)Cc1c[nH]c2ccccc12
InChIKeyLIURIBSBVUMOJS-UHFFFAOYSA-N
PubChem CID131007
ChEMBLCHEMBL3286869
DTXSIDDTXSID40155922

Chemische & physikalische Eigenschaften

XLogP0,6
Polarare Oberfläche (TPSA)130
H-Brücken-Donoren7
H-Brücken-Akzeptoren7
Frei drehbare Bindungen22
Schwere Atome35
Formalladung0
Komplexität526

Sicherheit & Vorschriften

TreatmentFirst aid for funnel-web bites consists of applying a pressure immobilization bandage to slow venom movement. Further supportive care may be necessary, but the mainstay of treatment is antivenom. (L1036)
Gesundheitliche Auswirkungenalpha-Agatoxin causes a rapid reversible paralysis. Death can result from progressive hypotension or possibly raised intracranial pressure resulting from cerebral oedema. (L1024, L1036)
ExpositionspfadeInjection (sting/bite) (L1812)
Toxizitätsübersichtalpha-Agatoxins block the glutamate-activated receptor channels in the neuronal postsynaptic terminals of insects and mammals, preventing excitory junction potential from developing. (L1024)
Signs and SymptomsThe bites of funnel-web spiders may cause tingling around the mouth and tongue, facial muscle twitching, nausea, vomiting, profuse sweating, salivation, and shortness of breath. Patients may also rapidly develop agitation, confusion and coma associated with hypertension, metabolic acidosis, dilation of the pupils, generalised muscle twitching and pulmonary oedema. (L1036)
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).