N-1,3-Dimethylbutyl-N'-phenyl-p-phenylendiamin

Fires involving this material should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Use water spray, powder.

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personal protection: protective gloves and particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

Cough.

Redness.

Redness.

TEN AUTOMOBILE TIRES MFR BY 8 FIRMS INDUCED CONTACT SENSITIVITY IN 7 SUBJECTS ALLERGIC TO N-ISOPROPYL-N'-PHENYL-P-PHENYLENEDIAMINE ANTIOZONANT. N-(1,3-DIMETHYLBUTYL)-N'-PHENYL-P-PHENYLENEDIAMINE, AN ANTIOZONANT PURPORTED TO BE NONSENSITIZING, GAVE POS RESPONSES IN ALL PATIENTS ALLERGIC TO N-ISOPROPYL-N'-PHENYL-P-PHENYLENEDIAMINE.

The case of a 48 year old woman who had worked for 16 years in a rubber factory, in the quality control department of a rubber factory was discussed. Part of her work included the weighing of rubber chemicals, primarily in powdered form or as pellets. Although the patient wore leather gloves and a face mask, after a short period of time pruritus, erythema and vesicles developed on the uncovered skin of the hands and neck. Contact allergies were noted to N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine, 2,2,4-trimethyl-1,2-dihydroquinoline and also to N-isopropyl-N'-phenyl-p-phenylenediamine. When away from her work, the patient did heal, only to relapse on returning to the job.

N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine was evaluated for mutagenicity in the Salmonella/microsome preincubation assay using a standard protocol approved by the National Toxicology Program. Doses of 0, 0.1, 0.3, 1, 3.3, 10, 33, 100, and 200 ug/plate were tested in four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) in the presence and absence of Aroclor-induced rat or hamster liver S9. These tests were negative and the highest ineffective dose level tested in all four Salmonella tester strains under all treatment conditions was 3.3 ug/plate. The four highest dose levels caused clearing of the background lawn.

N-(1,3-Dimethylbutyl)-N-phenylparaphenylenediamine is a derivative of phenylenediamine which is widely used in the rubber industry as an antioxidant. N-(1,3-Dimethylbutyl)-N-phenylparaphenylenediamine which is a strong allergen, is least studied for its clastogenic potency. This study evaluated the genotoxic property of DMPPD in Swiss albino mice bone marrow cells by using chromosomal aberration and micronuclei assay. Three concentrations of N-(1,3-dimethylbutyl)-N-phenylparaphenylenediamine, i.e., 100, 150 and 200 mg/kg body wt. did not significantly increase the micronuclei in polychromatic erythrocytes or the ratio of poly to normochromatic erythrocytes. Chromosome aberration studies using 100 mg and 200 mg/kg body wt. showed that N-(1,3-dimethylbutyl)-N-phenylparaphenylenediamine is a non-inducer of chromosome aberrations. The results indicated non-clastogenicity of N-(1,3-dimethylbutyl)-N-phenylparaphenylenediamine in mice marrow cells up to a concentration of 200 mg/kg bw under our experimental conditions.