Pagoclone
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Grundinformationen
- CAS
133737-32-3- Standard-SMILES
CC(C)CCC(=O)CC1c2ccccc2C(=O)N1c1ccc2ccc(Cl)nc2n1- InChIKey
HIUPRQPBWVEQJJ-UHFFFAOYSA-N- Summenformel
- C23H22ClN3O2
- Durchschnittliche Molmasse
- 407,9 g/mol
- Monoisotopische Masse
- 407,1400546
Überblick
Pagoclone is an anxiolytic drug from the cyclopyrrolone family, which is related to other more well known drugs such as the sleeping medication zopiclone. It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with quite different chemical structures.
Namen und Bezeichner
- Bevorzugter Name
- Pagoclone
- IUPAC
- 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-3H-isoindol-1-one
- Englischer Name
- Pagoclone
- Summenformel
- C23H22ClN3O2
- Molmasse
- 407.89
Namen und Synonyme
Pagoclone133737-32-3IP 456PagoclonaRP 62955RP-62955IP-456CI-10432-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-2,3-dihydro-1H-isoindol-1-one38VAG2SA33DTXSID40869830IP456
Weitere Namen anzeigen
Pagoclone Labeled d42-(7-Chloro-2-naphthyridin-1,8-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone1H-Isoindol-1-one, 2-(7-chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-
RP62955pagoclonumRefChem:858293DTXCID908177402-(7-chloro-1.8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-1H-isoindol-1-one133737-48-1rac-Pagoclone2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one
Datenbank-Bezeichner
- CAS
133737-32-3、133737-48-1
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 4,6
- Polarare Oberfläche (TPSA)
- 63,2 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 29
- Formalladung
- 0
- Komplexität
- 613
Experimentelle und physikochemische Eigenschaften
LogP4.8
Physikochemische Eigenschaften
- Schmelzpunkt
- 173 · 173-179°C
- storage temp.
- -20 °C · -20°C Freezer
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- Pale Orange to Pale Red
Chemie und Industrie
Pharmakologische Informationen
Pharmacodynamics
Pagoclone was originally developed as an anti-anxiety drug, but never commercialised. It is a partial agonist acting at GABAA receptors in the brain. In contrast to zopiclone, pagoclone produces anxiolytic effects with little or no sedative or amnestic actions at low doses.
Mechanism of Action
Pagoclone is a subtype-selective drug which binds primarily to the alpha2/alpha3 subtypes of the GABAA receptor which are responsible for the anti-anxiety effects of these kind of drugs, but has relatively little efficacy at the alpha1 subtype which produces the sedative and memory loss effects.
Anwendungen
VerwendenPagoclone is a partial GABAA agonist, used to reduce panic attacks and appear to decrease symptoms of generalized anxiety.
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