Huangjiangsu A
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Grundinformationen
- CAS
1026020-27-8- Standard-SMILES
CC1=C(CC[C@@H](C)CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)O[C@H]2C[C@H]3[C@@H]4CC=C5C[C@@H](O[C@@H]6O[C@H](CO)[C@@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O)CC[C@]5(C)[C@H]4CC[C@]3(C)[C@@H]12- InChIKey
FTNRXHIYUXAZFP-JNHRZEBYSA-N- Summenformel
- C51H82O22
- Durchschnittliche Molmasse
- 1.047,195 g/mol
- Monoisotopische Masse
- 1.046,52977426
Namen und Bezeichner
- Bevorzugter Name
- Huangjiangsu A
- Englischer Name
- HuangjiangSu A
- Summenformel
- C51H82O22
- Molmasse
- 1047.2
Namen und Synonyme
HuangjiangSu Aβ-D-Glucopyranoside, (3β,25R)-26-(β-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-(3beta,25R)-26-(beta-D-Glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-4)]-beta-D-glucopyranoside
Datenbank-Bezeichner
- CAS
1026020-27-8- PubChem CID
- 134687322
- DTXSID
DTXSID701355512- UNII
- I2UTW331KU
- Nikkaji
- J3.746.090G
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 274 · 274-276 °C
- Dichte
- 1.48 · 1.48±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- Soluble in DMSO
- pka
- 12 · 12+-.0.70(Predicted)
Chemie und Industrie
Anwendungen
BeschreibungHuangjiangsu A is a natural active ingredient found in many plants such as Dioscorea villosa and Polygonatum multiflorum. It belongs to the steroidal saponin class of compounds. Huangjiangsu A is not cytotoxic, and treatment of HepG2 cells with it prior to exposure to H2O2 was effective in increasing cell viability in a concentration-dependent manner. In addition, 50 μM of Huangjiangsu A, pseudoprotodioscin, methyl protobioside, protodioscin, and protodeltonin increased GSH levels and reduced intracellular ROS production, thereby counteracting H2O2-induced injury. Thus, Huangjiangsu A has hepatoprotective potential against H2O2-induced cytotoxicity and ROS generation, and is expected to be a potential drug for the treatment of liver diseases[1-2].
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