HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Phenbenzamine
PM-245 · Bridal · Antergan · Lergitin · Fourneau compound-2339RP · benzyl-(2-dimethylaminoethyl)-phenyl-amine · N',N'-dimethyl-N-phenyl-N-(phenylmethyl)ethane-1,2-diamine · 1,2-Ethanediamine, N1,N1-dimethyl-N2-phenyl-N2-(phenylmethyl)-
Identifikatoren & physikalische Daten
| CAS No. | 961-71-7 |
|---|---|
| Summenformel | C17H22N2 |
| Durchschnittliche Molmasse | 254,37 g/mol |
| Monoisotopische Masse | 254,17829871 g/mol |
| SMILES | CN(C)CCN(Cc1ccccc1)c1ccccc1 |
| InChIKey | CHOBRHHOYQKCOU-UHFFFAOYSA-N |
| PubChem CID | 13751 |
| ChEMBL | CHEMBL157118 |
| ChEBI | CHEBI:135041 |
| DTXSID | DTXSID3043863 |
Chemische & physikalische Eigenschaften
| XLogP | 3,7 |
|---|---|
| Polarare Oberfläche (TPSA) | 6,5 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 6 |
| Schwere Atome | 19 |
| Formalladung | 0 |
| Komplexität | 227 |
| Dichte | 1.019 (NTP, 1992) - Denser than waterwill sink1.0160 |
| Siedepunkt | 354 to 356 °F at 7 mmHg (NTP, 1992)387.59°C (rough estimate) |
| Physical Description | Phenbenzamine is a liquid. (NTP, 1992) |
| Brechungsindex | 1.5794 |
| Farbe | Pale-yellow oil |
| EPA chemische Informationen | Phenbenzamine (961-71-7) |
Sicherheit & Vorschriften
| Gesundheitsgefahren | ACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products. (NTP, 1992) |
|---|---|
| Reaktive Gruppe | Amines, Phosphines, and Pyridines |
| Reactivity Profile | PHENBENZAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. |
| Air and Water Reactions | No rapid reaction with air. No rapid reaction with water. |
| Brandbekämpfung | This compound is not very flammable but any fire involving this compound may produce dangerous vapors. You should evacuate the area. All firefighters should wear full-body protective clothing and use self-contained breathing apparatuses. You should extinguish any fires involving this chemical with a dry chemical, carbon dioxide, foam, or halon extinguisher. (NTP, 1992) |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: Dampen spilled material with toluene to avoid dust, then transfer material to a suitable container. Use absorbent paper dampened with toluene to pick up remaining material. Wash surfaces well with soap and water. Seal all waste in vapor-tight plastic bags for eventual disposal. |
| Personal Protective Equipment (PPE) | RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992) |
| Toxizität | LDLo ipr-rat: 120 mg/kg BJPCAL 11,1,56 |
Anwendungen & Verwendung
History
In 1942 phenbenzamine (Antergan), C17H22N2, was the first antihistamine to be successfully used in humans.