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Cyclopentyl methyl ether
CPME · CMPE · METHOXYCYCLOPENTANE · Cyclpentyl methyl ether · DKJ33F · Cyclopentane,methoxy- · cyclopentyl-f whatsapp · cyclopentyl methyl ethe
Identifikatoren & physikalische Daten
| CAS No. | 5614-37-9 |
|---|---|
| Summenformel | C6H12O |
| Durchschnittliche Molmasse | 100,16 g/mol |
| Monoisotopische Masse | 100,088815 g/mol |
| SMILES | COC1CCCC1 |
| InChIKey | SKTCDJAMAYNROS-UHFFFAOYSA-N |
| PubChem CID | 138539 |
| EC No. | 445-090-6 |
| DTXSID | DTXSID2074958 |
Chemische & physikalische Eigenschaften
| XLogP | 1,3 |
|---|---|
| Polarare Oberfläche (TPSA) | 9,2 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 1 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 7 |
| Formalladung | 0 |
| Komplexität | 46 |
| Physical Description | Liquid |
| Kovats Retention Index | 760 |
| Schmelzpunkt | -140°C |
| Siedepunkt | 106°C |
| Dichte | 0.86 |
| Dampfdruck | 59.9 hPa (25 °C) |
| Flammpunkt | -1°C(lit.) |
| Brechungsindex | 1.4210 |
| Lagerbedingungen | Store below +30°C. |
| Löslichkeit | Chloroform (Sparingly), Methanol (Slightly)Miscible with water, alcohols, ketones and hydrocarbons. |
| Aggregatzustand | Liquid |
| Farbe | APHA: ≤10 |
| Explosionsgrenze | 1.10-9.90% |
| Stabilität | Volatile |
| InChI | 1S/C6H12O/c1-7-6-4-2-3-5-6/h6H,2-5H2,1H3 |
| InChIKey | SKTCDJAMAYNROS-UHFFFAOYSA-N |
| SMILES | COC1CCCC1 |
| LogP (Verteilungskoeffizient) | 1.6 at 20℃ |
| EPA chemische Informationen | Cyclopentane, methoxy- (5614-37-9) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]H312 (32.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]H315 (62.6%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (95.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]P210, P233, P240, P241, P242, P243, P264, P264+P265, P270, P280, P301+P317, P302+P352, P303+P361+P353, P305+P351+P338, P317, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P235, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 115 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatorische Informationen | Cyclopentane, methoxy- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Cyclopentane, methoxy- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.Status: Active Update: 30-07-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/26626Status: Active Update: 29-04-2015 https://echa.europa.eu/registration-dossier/-/registered-dossier/6163 |
| Peroxide Forming Chemical | Cyclopentyl methyl ether (CPME)D: Other compounds that may form peroxides1 ppm open new bottle, 3-10 ppm after 3 hours of air sparging and uv light on a 5 mL sample in a 50 mL flask.683 days to reach 100 ppm, 20 mL of sample in a brown 65 mL bottleWatanabe et al - Org. Process Res. Dev.Peroxide formation is slow (based on literature studies), but the reagent is still inhibited with BHT to provent possible peroxide formation.https://doi.org/10.1021/op0680136https://doi.org/10.1246/cl.2008.774 |
| Hazard Classes and Categories | Flam. Liq. 2 (100%)Acute Tox. 4 (100%)Acute Tox. 4 (32.2%)Skin Irrit. 2 (62.6%)Eye Irrit. 2 (95.7%)Acute Tox. 4 (98%)Skin Irrit. 2 (100%)Eye Irrit. 2 (100%)Aquatic Chronic 3 (37.3%) |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN3271 |
| Zollcode | 2909 20 00 |
| R-Sätze (R) | 11-22-36/38 |
| Toxizität | LD50 orally in Rabbit: 200 - 2000 mg/kg LD50 dermal Rat > 2000 mg/kg |
| Gefahrensymbole | F,Xn |
| Sicherheitshinweise (S) | 26 |
| Gefahrenklasse | 3Acute Tox. 4 OralEye Irrit. 2Flam. Liq. 2Skin Irrit. 2 |
| Verpackungsgruppe | II |
| Lagerklasse | 3 - Flammable liquids |
| Selbstentzündungstemperatur | 180 °C |
Anwendungen & Verwendung
Verwenden
Cyclopentyl methyl ether (CPME) is an alternative to ether solvents such as THF, diethyl ether, and MTBE with a higher resistance to peroxide formation. The more environmentally conservative CPME solvent replaces hazardous solvents in order to achieve sustainability and reduce environmental and operational costs. CPME offers considerable potential and advantage as a direct replacement for CH2Cl2 in binary eluents using MeOH as the modifier with MeOH-DMC and i-PrOH-EtOAc.