Boc-His(Trt)-OH
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Grundinformationen
- CAS
32926-43-5- Standard-SMILES
CC(C)(C)OC(=O)N[C@@H](Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)C(=O)O- InChIKey
OYXZPXVCRAAKCM-SANMLTNESA-N- Summenformel
- C30H31N3O4
- Durchschnittliche Molmasse
- 497,59 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Boc-His(Trt)-OH
- Englischer Name
- Boc-His(Trt)-OH
- Summenformel
- C30H31N3O4
- Molmasse
- 497.59
Namen und Synonyme
BOC-HIS(TRT)-OHBoc-His(trt)His(Trt)-OHBOC-L-HIS(TRT)-OHBoc-L-His(Trt)Impurity HA-1N-Boc-His(Trt)-OH(S)-L-Boc-his(trt)-ohBoc-His(Trt)-OH, >=98%BOC-N-IM-TRITYL-L-HISTIDINE
Datenbank-Bezeichner
- CAS
32926-43-5- PubChem CID
- 13968084
- UNII
- C9YH4KHR73
- EC Number
- 685-644-6
- Nikkaji
- J3.560.619J
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 130 °C · ~130 °C (dec.)
- Siedepunkt
- 667.5 · 667.5±55.0 °C(Predicted)
- Dichte
- 1.16 · 1.16±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Löslichkeit
- DMSO (Slightly), Methanol (Sparingly)
- pka
- 3.17 · 3.17±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- BRN
- 732035 · 732035
- Major Application
- peptide synthesis
- InChIKey
- OYXZPXVCRAAKCM-SANMLTNESA-N
- SMILES
- C(O)(=O)[C@H](CC1N=CN(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=1)NC(OC(C)(C)C)=O
- CAS Datenbank
- 32926 · 32926-43-5(CAS DataBase Reference)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- hs_code
- 29224999
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
VerwendenBoc-His(Trt)-OH was used in the study to prepare and study structure-activity relationship of amino acid amides as selective inhibitors for dipeptidyl peptidases.
VerwendenBoc-His(Trt)-OH is a histidine derivative. Its a protected histidine derivative for only the critical coupling step. After coupling the Boc- and Trt-groups are cleaved simultaneously by TFA.
Darstellung
synthetischeThe benzyl 2-tert-butoxycarbonylamino-3-(1-trimethylimidazol-4-yl)propionate was dissolved in methanol (20 mL), and potassium hydroxide was added to the reaction system. The reaction system was stirred for 1 h after THF was added to the reaction system. The solvent is removed under vacuum depressurization, and the mixture is then extracted with water and Et2O. Separate the two phases and acidify the aqueous layer with dilute HCl, extract it with Et2O, combine all the ether organic layer and wash it with water and saline, dry the organic layer with anhydrous magnesium sulfate, filter to remove the solvent, and concentrate the filtrate under vacuum under reduced pressure to obtain Boc-His(Trt)-OH.
Anbieter100 Anbieter
北京华美互利生物化工010-56205725 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
江苏生康迈翔科技有限公司18217475093 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
温州共赢化学有限公司+86-0086-577-64498589 +86-15355981851 · [email protected]
Hangzhou Go Top Peptide Biotech
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