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Methadone Hydrochloride

HCID 14184
NotizenReaktionen
GrundinformationenÜberblickNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
TeilstruktursucheÄhnliche Strukturen suchen

Grundinformationen

CAS
1095-90-5
Standard-SMILES
CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1.Cl
InChIKey
FJQXCDYVZAHXNS-UHFFFAOYSA-N
Summenformel
C21H28ClNO
Durchschnittliche Molmasse
345,9 g/mol
Monoisotopische Masse
345,1859422

Überblick

Methadone hydrochloride is a hydrochloride. It contains a methadone.

Namen und Bezeichner

Bevorzugter Name
Methadone Hydrochloride
IUPAC
6-(dimethylamino)-4,4-diphenylheptan-3-one;hydrochloride
Englischer Name
(+-)-Methadone hydrochloride--DEA
Summenformel
C21H28ClNO
Molmasse
345.90612

Namen und Synonyme

Methadone hydrochlorideAlgolysin1095-90-5ButalginFenadoneMecodinPhenadone hydrochlorideDolofin hydrochlorideKetalgin hydrochlorideHeptadonAdanon hydrochlorideDolophine hydrochloride
Weitere Namen anzeigen
tussalalgidonmacodinmiadonedepridolmephenonmoheptan
WestadoneAN-148AlthoseDTXSID20205016-(Dimethylamino)-4,4-diphenyl-3-heptanone hydrochlorideMethadone hydrochloride cii4,4-Diphenyl-6-dimethylamino-3-heptanone hydrochlorideNSC-19600

Datenbank-Bezeichner

CAS
1095-90-5、125-56-4
PubChem CID
14184
DTXSID
DTXSID2020501
ChEMBL
CHEMBL1200825
ChEBI
CHEBI:50140
UNII
229809935B
EC Number
214-140-7、621-092-4

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
20,3 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
2
Frei drehbare Bindungen
7
Schwere Atome
24
Formalladung
0
Komplexität
346

Experimentelle und physikochemische Eigenschaften

Human Drugs · 3 Einträge

Breast Feeding; Lactation; Milk, Human; Analgesics, Opioid; Narcotics; Antitussive Agents

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Animal DrugsPharmaceuticals -> UK Veterinary Medicines Directorate List

Physikochemische Eigenschaften

storage temp.
2 · 2-8°C
Löslichkeit
2 O: · H2O: >50 mg/mL, clear, colorless to yellow
Aggregatzustand
powder
Farbe
white to off-white

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 6 Einträge

Danger

H300 (94.8%): Fatal if swallowed [Danger Acute toxicity, oral]

P203, P233, P260, P261, P262, P264, P270, P271, P272, P280, P284, P301+P316, P302+P352, P304+P340, P316, P318, P321, P330, P333+P317, P342+P316, P361+P364, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 116 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H301 (97.5%): Toxic if swallowed [Danger Acute toxicity, oral]

Gefahrenhinweise

Regulatory InformationMethadone hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride: Environment tier I assessment
Fire Hazards · 3 Einträge

· Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

· Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.

Health Hazards · 3 Einträge

· Highly toxic, may be fatal if inhaled, ingested or absorbed through skin.

· Highly toxic, may be fatal if inhaled, ingested or absorbed through skin.

· TOXIC; may be fatal if inhaled, ingested or absorbed through skin.

DOT ID and Guide · 3 Einträge

3249 151

Chemie und Industrie

Pharmakologische Informationen

Metabolism/Metabolites · 1 Eintrag

Hepatic. Cytochrome P450 enzymes, primarily CYP3A4, CYP2B6, and CYP2C19 and to a lesser extent CYP2C9 and CYP2D6, are responsible for conversion of methadone to EDDP and other inactive metabolites, which are excreted mainly in the urine. Route of Elimination: The elimination of methadone is mediated by extensive biotransformation, followed by renal and fecal excretion. Unmetabolized methadone and its metabolites are excreted in urine to a variable degree. Half Life: 24-36 hours

FDA Pharmacological Classification · 2 Einträge

METHADONE HYDROCHLORIDE

Full Opioid Agonists [MoA]; Opioid Agonist [EPC]

MeSH Pharmacological Classification · 3 Einträge

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.

Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.

Verwendung und Herstellung

UsesFor the treatment of dry cough, drug withdrawal syndrome, opioid type drug dependence, and pain (A308).

Zugehörige Reaktionen

2
Reaktionsaufzeichnung erstellen
Reaktionsgleichung von HRID 83479
HRID 83479als Eduktuspto-grants-2014_09
Reaktionsgleichung von HRID 2396431
HRID 2396431als Eduktuspto-grants-1996_02

Notizen zur Verbindung

Wird geladen…

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1851 151

3248 131

DOT Hazard Classification · 6 Einträge

Medicine, liquid, flammable, toxic, n.o.s

UN3248

Class 3 Flammable and combustible liquid (49 eCFR § 173.120)

Class 3 Flammable and combustible liquid (49 eCFR § 173.120)

PG II: the degree of danger presented by the material is medium

Medicine, liquid, toxic, n.o.s

Hazard Classes and Categories · 2 Einträge

Acute Tox. 2 (94.8%)

Acute Tox. 3 (97.5%)

Sicherheit und Schutzausrüstung

Accidental Release Measures · 6 Einträge

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

First Aid · 3 Einträge

General First Aid:

General First Aid:

General First Aid:

Exposure Control and Personal Protection · 3 Einträge

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear positive pressure self-contained breathing apparatus (SCBA).

Isolation and Evacuation · 3 Einträge

Immediate precautionary measure

Immediate precautionary measure

Immediate precautionary measure

Emergency Response Planning Guidelines · 3 Einträge

Small Fire

Small Fire

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

Toxikologische Informationen

Treatment · 1 Eintrag

Primary attention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilation. If a non-tolerant person, takes a large dose of methadone, effective opioid antagonists are available to counteract the potentially lethal respiratory depression. (L1712)

Health Effects · 1 Eintrag

Bradycardia and hypotension. In severe overdosage, particularly by the intravenous route, apnea, circulatory collapse, cardiac arrest, and death may occur (RxList, A308). Medical problems can include congested lungs, liver disease, tetanus, infection of the heart valves, skin abscesses, anemia and pneumonia. Death can occur from overdose.

Exposure Routes · 1 Eintrag

Inhalation (MSDS, RxList, A308); dermal (MSDS, RxList, A308); ingestion (MSDS, RxList, A308); intravenous injection (MSDS, RxList, A308). Well absorbed following oral administration. The bioavailability of methadone ranges between 36 to 100%.

Toxicity Summary · 1 Eintrag

Methadone is a mu-agonist; a synthetic opioid analgesic with multiple actions qualitatively similar to those of morphine, the most prominent of which involves the central nervous system and organs composed of smooth muscle. The principal therapeutic uses for methadone are for analgesia and for detoxification or maintenance in opioid addiction. The methadone abstinence syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, the course is more prolonged, and the symptoms are less severe. Some data also indicate that methadone acts as an antagonist at the N-methyl-D-aspartate (NMDA) receptor. The contribution of NMDA receptor antagonism to methadone's efficacy is unknown. Other NMDA receptor antagonists have been shown to produce neurotoxic effects in animals.

Signs and SymptomsIn severe overdosage, particularly by the intravenous route, apnea, circulatory collapse, cardiac arrest, and death may occur.
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Drug Induced Liver Injury · 6 Einträge

Drug Induced Liver Injury Rank (DILIrank 2.0)

Methadone hydrochloride

Ambiguous-DILI-concern

3

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

Sicherheitsdaten

wgk
3
ridadr
UN 3249
RTECS-Nr.
MJ6300000
risk_code
25
hazard_code
T
safety_code
45
hazard_class
6.1
packing_group
II/III