Oxidase, Urat

Urate Oxidase

HCID 14228836

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Grundinformationen

CAS: 9002-12-4
Standard-SMILES: N.O=c1ccn(C2OC(COP(=O)(O)OC3C(CO)OC(n4ccc(=O)[nH]c4=O)C3O)C(O)C2O)c(=O)[nH]1
InChIKey: VPXDHZMLJOJKOX-UHFFFAOYSA-N
Summenformel: C18H26N5O14P
Durchschnittliche Molmasse: 567,4 g/mol

Überblick

An enzyme that catalyzes the conversion of urate and unidentified products. It is a copper protein. The initial products decompose to form allantoin. EC 1.7.3.3.

Namen und Bezeichner

Bevorzugter Name: Urate Oxidase
IUPAC: azane;[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate
Lokaler Name: Oxidase, Urat
Englischer Name: URICASE
Summenformel: C18H26N5O14P
Molmasse: 567.397901

Namen und Synonyme

Oxidase, urate9002-12-4Urate OxidaseRefChem:901193Urate:oxygen oxidoreductaseURATE OXIDASE [WHO-DD]232-655-5azane;[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphateUricase from Bacillus fastidiosusUricase from Candida utilisUricase from Bacillus fastidiosus, lyophilized, ~9 U/mgUricase from Arthrobacter globiformis, lyophilized powder, 15-30 units/mg protein (biuret)

Weitere Namen anzeigen

UAOUA-RUA-TURICASEC:C&B40UricozymeEC 1.7.3.3EC: 1.7.3.3urikoxidaseUratoxidase

Uricase from Candida sp., recombinant, expressed in E. coli, lyophilized powder, >=2 units/mg solid

Datenbank-Bezeichner

CAS: 9002-12-4
PubChem CID: 14228836
EC Number: 232-655-5

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA): 255 Å²
H-Brücken-Donoren: 8
H-Brücken-Akzeptoren: 15
Frei drehbare Bindungen: 8
Schwere Atome: 38
Formalladung: 0
Komplexität: 1.070

Experimentelle und physikochemische Eigenschaften

Human DrugsBreast Feeding; Lactation; Milk, Human; Enzymes; Gout Suppressants; Urate Oxidase

Physikochemische Eigenschaften

storage temp.: -20 °C · -20°C
Löslichkeit: 5 mg/mL, · 5 mg/mL, clear, colorless to very faintly yellow (in enzyme dilution buffer)
Aggregatzustand: lyophilized powder
Farbe: White to off-white
Biologische Quelle: Bacillus sp. (B. fastidiosus)
Wasserlöslichkeit: Hardly soluble in water, slightly soluble in buffer alkaline solution.
Merck: 13 · 13,9944
Specific Activity: 15 · 15-30units/mg protein (biuret)
Major Application: detection
InChIKey: VPXDHZMLJOJKOX-UHFFFAOYSA-N
SMILES: N.OCC1OC(C(O)C1OP(O)(=O)OCC2OC(C(O)C2O)N3C=CC(=O)NC3=O)N4C=CC(=O)NC4=O
EPA chemische Informationen: Oxidase, urate (9002-12-4)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

This chemical does not meet GHS hazard criteria for 50% (1 of 2) of reports.

Danger

H334 (50%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

P233, P260, P271, P284, P304+P340, P342+P316, P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory.

Gefahrenhinweise

Regulatory Information · 3 Einträge

Chemical: Oxidase, urate

XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).

Oxidase, urate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Other Safety InformationIMAP assessments - Oxidase, urate: Environment tier I assessment

Toxikologische Informationen

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

Sicherheitsdaten

F: 10-21
wgk: 3
tsca: TSCA listed
hs_code: 35079090
RTECS-Nr.: YU7100000
safety_code: 24/25
Speicherklasse: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
Hazard Classifications: Eye Irrit. 2Repr. 1BResp. Sens. 1

Chemie und Industrie

Pharmakologische Informationen

ATC Code · 2 Einträge

M - Musculo-skeletal system

QM - Musculo-skeletal system

Verwendung und Herstellung

General Manufacturing InformationUrate oxidase: ACTIVE

Anwendungen · 1 Eintrag

VerwendenUricase is very important for the determination of uric acid in biological fluids. Uricase is an important medical enzyme which can be used to determine urate in clinical analysis. The enzyme Urate oxidase (UO) catalyzes the oxidation of uric acid to 5-hydroxyisourate.