HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
S-Ethyl-N-cyclohexylthiocarbamat
SABET · EUREX · Ronit · etsan · R-2063 · RO-NEET · CYCLOATE · Cycolate
Identifikatoren & physikalische Daten
| CAS No. | 1134-23-2 |
|---|---|
| Summenformel | C11H21NOS |
| Durchschnittliche Molmasse | 215,36 g/mol |
| Monoisotopische Masse | 215,13438547 g/mol |
| SMILES | CCSC(=O)N(CC)C1CCCCC1 |
| InChIKey | DFCAFRGABIXSDS-UHFFFAOYSA-N |
| PubChem CID | 14337 |
| ChEMBL | CHEMBL1889969 |
| ChEBI | CHEBI:81955 |
| EC No. | 214-482-7 |
| DTXSID | DTXSID6032356 |
| Lokaler Name | S-Ethyl-N-cyclohexylthiocarbamat |
Chemische & physikalische Eigenschaften
| XLogP | 4,1 |
|---|---|
| Polarare Oberfläche (TPSA) | 45,6 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 4 |
| Schwere Atome | 14 |
| Formalladung | 0 |
| Komplexität | 178 |
| LogP (Verteilungskoeffizient) | log Kow = 3.88 |
| Geruch | Aromatic |
| Dichte | 1.016 at 30 °C/4 °C1.0156 |
| Color/Form | Colorless liquidOily |
| Löslichkeit | Miscible with most organic solvents, e.g. acetone, benzene, methanol, ethanol, xylene, kerosene, etc.Miscible with 4-methylpentan-2-oneIn water, 85 mg/L at 22 °C85mg/L(22 ºC) |
| Corrosivity | Noncorrosive |
| Flammpunkt | 139 °C (TAG OPEN CUP)>100 °C |
| Siedepunkt | 145 °C at 10 mm Hg145 °C(Press: 10 Torr) |
| Decomposition | When heated to decomposition it emits toxic fumes of /sulfur and nitrogen oxides/. |
| Schmelzpunkt | 11.5 °C11.5°C |
| Dampfdruck | 0.002 [mmHg]1.57X10-3 mm Hg at 25 °C0.002Pa at 25℃ |
| Brechungsindex | INDEX OF REFRACTION: 1.5054 @ 30 °C/D1.5500 (estimate) |
| Lagerbedingungen | 0-6°C |
| Aggregatzustand | Liquid |
| pKa (Säurekonstante) | -1.30±0.20(Predicted) |
| BRN | 2937178 |
| Henry-Konstante | 1.9×100 mol/(m3Pa) at 25℃, HSDB (2015) |
| Hauptanwendungen | agricultureenvironmental |
| InChI | 1S/C11H21NOS/c1-3-12(11(13)14-4-2)10-8-6-5-7-9-10/h10H,3-9H2,1-2H3 |
| InChIKey | DFCAFRGABIXSDS-UHFFFAOYSA-N |
| SMILES | CCSC(=O)N(CC)C1CCCCC1 |
| LogP (Verteilungskoeffizient) | 3.88 at 20℃ |
| CAS Datenbank | 1134-23-2 |
| EPA chemische Informationen | Cycloate (1134-23-2) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 6.7% (3 of 45) of reports.WarningH302 (86.7%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 45 reports by companies from 5 notifications to the ECHA C&L Inventory.Reported as not meeting GHS hazard criteria per 3 of 45 reports by companies.There are 4 notifications provided by 42 of 45 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatorische Informationen | Hazard Traits - Developmental ToxicityAuthoritative List - Prop 65Report - regardless of intended function of ingredient in the productCycloate is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)Status: Active Update: 18-12-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/27457The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| DOT-Kennzeichnung | Class 9 |
| Brandgefahren | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:Some may burn but none ignite readily. Containers may explode when heated. Some may be transported hot. For UN3508, Capacitor, asymmetric, be aware of possible short circuiting as this product is transported in a charged state. Polymeric beads, expandable (UN2211) may evolve flammable vapours. (ERG, 2024) |
| Brandpotenzial | Fire point: 149 °C |
| Gesundheitsgefahren | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:Inhalation of material may be harmful. Contact may cause burns to skin and eyes. Inhalation of Asbestos dust may have a damaging effect on the lungs. Fire may produce irritating, corrosive and/or toxic gases. Some liquids produce vapors that may cause dizziness or asphyxiation. Runoff from fire control or dilution water may cause environmental contamination. (ERG, 2024) |
| Gefahrenübersicht | A skin and eye irritant[HSDB] May cause irritation[MSDSonline] Oral LD50 (rat) = 1652 mg/kgDermal LD50 (rat) = 3200 mg/kg[Ullmann] |
| Reaktive Gruppe | Thiocarbamate Esters and Salts/Dithiocarbamate Esters and Salts |
| Special Reports | USEPA/OPPTSReregistration Eligibility Decision (RED) for Cycloate (S-ethyl cyclohexyl(ethyl)thiocarbamate) 112 pp. (September 30, 2004) This document provides a thorough review of the scientific data underlying this herbicidee's registration and fulfills the EPA's requirement to determine whether herbicides containing this active ingredient are eligible for reregistration before calling in data on products. |
| FIFRA-Anforderungen | Tolerances are established for residues of the herbicide S-ethyl cyclohexylethylthiocarbamate in or on the following food commodities: [Table#3498]Section 4(g)(2)(A) of FIFRA calls for the Agency to determine, after submission of relevant data concerning an active ingredient, whether or not products containing the active ingredient are eligible for reregistration. The Agency has previously identified and required the submission of the generic (i.e., active ingredient-specific) data required to support reregistration of products containing cycloate as an active ingredient. The Agency has completed its review of these generic data and has determined that the data are sufficient to support reregistration of all products containing cycloate. Appendix B identifies the generic data requirements that the Agency reviewed as part of its determination of reregistration eligibility of cycloate. These data were sufficient to allow the Agency to determine that cycloate can be used without resulting in unreasonable adverse effects to humans and the environment. The Agency, therefore, finds that all products containing cycloate as the active ingredient are eligible for reregistration provided specified changes are made to the label and additional data identified in Section V of this RED confirm this conclusion. Actions needed to reregister particular products are addressed in Section V of /the RED/ document.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Cycloate is found on List B. Case No: 2125Pesticide type: herbicideCase Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.Active ingredient (AI): S-Ethyl N-ethylcyclohexanecarbamothioateData Call-in (DCI) Date(s): 04/05/91, 10/18/95AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner. |
| Reactivity Profile | CYCLOATE is a thiocarbamate ester. Flammable gases are generated by the combination of thiocarbamates and dithiocarbamates with aldehydes, nitrides, and hydrides. Thiocarbamates and dithiocarbamates are incompatible with acids, peroxides, and acid halides. |
| Air and Water Reactions | Thio and dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids or alkalis. |
| Hazard Classes and Categories | Acute Tox. 4 (86.7%)Teratogens |
| Brandbekämpfung | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:CAUTION: Fire involving Safety devices (UN3268) and Fire suppressant dispersing devices (UN3559) may have a delayed activation and a risk of hazardous projectiles. Extinguish the fire at a safe distance.SMALL FIRE: Dry chemical, CO2, water spray or regular foam.LARGE FIRE: Water spray, fog or regular foam. Do not scatter spilled material with high-pressure water streams. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.FIRE INVOLVING TANKS: Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024) |
| Erste Hilfe | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:Refer to the "General First Aid" section. (ERG, 2024) |
| Brandbekämpfungsverfahren | If material /is/ on fire or involved in /a/ fire do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide. /Carbamate pesticide, liquid, nos, (compounds and preparations) (agricultural insecticides, nec, liquid)Carbamate pesticide, liquid, nos (compounds and preparations) (agricultural insecticides, nec, liquid)Carbamate pesticide, liquid, nos (compounds and preparations) (insecticides, other than agricultural, nec/Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Solid streams of water may be ineffective. Use foam, dry chemical, or carbon dioxide. /Carbamate pesticide, liquid nos (compounds and preparations) (insecticides, other than agricultural, nec)/Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical or carbon dioxide. /Carbamate pesticide, solid, nos (compounds and preparations) (insecticides, other than agricultural, nec)/Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Carbamate pesticide, solid, nos (compounds and preparations) (agricultural insecticides, nec, other than liquid)/ |
| Lagerbedingungen | Keep containers closed when not in use. Do not store near seeds, fertilizers, or foodstuffs. Protect from temperatures below 20 °F. Product crystallizes at lower temperatures. Warm or store at higher temperatures and mix to redissolve crystals and assure uniformity before use. Do not store near sources of heat or open flame. Combustible liquid. /RO-NEET 6-E/Store away from feed, foodstuffs and out of the reach of children. Prevent drifting. |
| Reinigungsverfahren | Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System (NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance, contact your State Water Board or Regional Office of the EPA. |
| Freisetung ohne Brand | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent dust cloud. For Asbestos, avoid inhalation of dust. Cover spill with plastic sheet or tarp to minimize spreading. Do not clean up or dispose of, except under supervision of a specialist.SMALL DRY SPILL: With clean shovel, place material into clean, dry container and cover looselymove containers from spill area.SMALL SPILL: Pick up with sand or other non-combustible absorbent material and place into containers for later disposal.LARGE SPILL: Dike far ahead of liquid spill for later disposal. Cover powder spill with plastic sheet or tarp to minimize spreading. Prevent entry into waterways, sewers, basements or confined areas. (ERG, 2024) |
| Entsorgungsverfahren | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.Pesticide DIsposal: Wastes resulting from the use of this product may be disposed of on site or at an approved waste disposal facility. /RO-NEET 6-E/Container Disposal: Triple rinse (or equivalent)then offer for recycling or reconditioning, or puncture and dispose of in a sanitary land fill, or by other procedures approved by State and local authorirites. For bulk and mini-bulk containers, reseal conatiner and offer for reconditioning, or triple rinse (or equivalent) and offer for recycling or reconditioning, or clean in accordance with manufacturer's instructions. Before refilling, inspect thoroughly for damage such as cracks, punctures, bulges, dents, abrasions, and damaged or worn threads on closure devices. Refill only with RO-NEET 6-Ethe contents of these containers cannot be completely removed by cleaning. /RO-NEET 6-E/Do not contaminate water when disposing of equipment wash water or rinsate.For more Disposal Methods (Complete) data for CYCLOATE (6 total), please visit the HSDB record page. |
| Preventive Measures | For several good reasons, .... herbicides ... should be handled and applied only with full attention to safety measures that minimize personal contact. Many formulations contain adjuvants (stabilizers, penetrants, surfactants) that may have significant irritating and toxic effects. A number of premixed formulations contain two or more active ingredientsthe companion pesticides may be more toxic than the principal herbicide. Good hygienic practice should not be disregarded just because a pesticide is reported to have a high LD50 in laboratory rodents.Harmful if swallowed. Avoid contact with skin, eyes, and clothing. avoid contamination of feed or food. /RO-NEET 6-E//For liquid formulations/ follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry. Discard clothing and other absorbent materials that have been drenched or heavily contaminated with this product's concentrate. Do not reuse them.SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.For more Preventive Measures (Complete) data for CYCLOATE (14 total), please visit the HSDB record page. |
| Isolation and Evacuation | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directionsalso, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024) |
| Allowable Tolerances | Tolerances are established for residues of the herbicide S-ethyl cyclohexylethylthiocarbamate in or on the following food commodities: [Table#3497] |
| Personal Protective Equipment (PPE) | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)End-Use Products Intended for Occupational Use (Worker Protection Standard). For liquid formulations: Engineering controls are required for all mixers, loaders and applicators. All mixers, loaders, applicators, and other handlers must wear at a minumum: long-sleeved shirt and long pants, shoes plus socks, and chemical-resistant gloves and chemical-resistant apron when mixing and loading.Handlers /covered under the Worker Protection Standard and performing tasks using liquid formulations/, such as spill clean-up or cleaning equipment, for which engineering controls are not feasible must wear: long-sleeved shirt and long pants, shoes plus socks, chemical-resistant gloves, chemical-resistant apron, and a NIOSH-approved respirator with an organic-vapor removing cartridge with a prefilter approved for pesticides (MSHA/NIOSH approval number prefix TC-23C), or a canister approved for pesticides (MSHA/NIOSH approval number prefix TC-14G), or an organic-vapor cartridge or canister with any N2, R or P or He prefilter.Chemical resistant gloves /include/ barrier laminate or nitrile rubber or neoprene rubber or viton. /Ro-Neet 6-E/DO ALL LABORATORY SAMPLING, MIXING, WEIGHING, ETC, UNDER ... FUME REMOVAL DEVICE IN AREA HAVING GOOD FORCED VENTILATION OF NONRECIRCULATED AIR, OR WEAR GAS MASK OF PROPER TYPE. ... WEAR CLEAN PROTECTIVE CLOTHING AND NONPERMEABLE GLOVES (SUCH AS POLYETHYLENE GLOVES) AS NECESSARY. /51.041: SPECIAL CHEMICAL HAZARDS/Chemical-resistant gloves. Long-sleeved shirt and long pants. Shoes plus socks. |
| Treatment | Treatment of carbamate poisoning is similar to that of organophosphate poisoning in that atropine sulfate injections readily reverse the effects. For acute exposures and first aid: EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration. |
| Gesundheitliche Auswirkungen | Data concerning the effects of thiocarbamates on man are scarce. However, cases of irritation and sensitization have been observed among agricultural workers. Some thiocarbamates, e.g., molinate, have an effect on sperm morphology and, consequently, on reproduction. However, no teratogenic effects have been observed. The results of mutagenicity studies have shown that thiocarbamates containing dichloroallyl groups are highly mutagenic. Some thiocarbamates are acetylcholine esterase inhibitors. Acute exposure to cholinesterase inhibitors can cause a cholinergic crisis characterized by severe nausea/vomiting, salivation, sweating, bradycardia, hypotension, collapse, and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved. |
| Ökotoxizitätswerte | LC50Species: Oncorhynchus mykiss (Rainbow trout)Conditions: freshwater, staticConcentration: 4500 ug/L for 96 hr (95% confidence interval: 3000-8000 ug/L) /97.8% purity/Concentration: 5600 ug/L for 96 hr (95% confidence interval: 3800-8200 ug/L) /74.2% purity/Concentration: 6000 ug/L for 96 hr (95% confidence interval: 4600-7800 ug/L) /73.9% purity/LC50 Oncorhynchus mykiss (Rainbow trout) 7.0 ppm for 96 hrstatic /96.8% purity/ /from table/For more Ecotoxicity Values (Complete) data for CYCLOATE (15 total), please visit the HSDB record page. |
| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 345(2) to 800(3) indicate that cycloate is expected to have moderate mobility in soil(SRC). Volatilization of cycloate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.2X10-6 atm-cu m/mole(SRC), based upon its vapor pressure, 1.57X10-3 mm Hg(4), and water solubility, 85 mg/L(5). Cycloate is not expected to volatilize from dry soil surfaces(SRC) based upon its estimated vapor pressure(4). A field half-life of 30 days has been reported(5). 14C-labeled cycloate was up to 90% mineralized using a continuous flow-through system and soil inoculum(7), indicating that biodegradation is an important environmental fate process in soil(SRC).TERRESTRIAL FATE: UNDER CROP GROWING CONDITIONS, CYCLOATE HAS HALF-LIFE OF 4-8 WK IN SEVERAL SOILS. IN A LOAM SOIL AT 70-80 °F THE HALF-LIFE WAS 3.5 WK.AQUATIC FATE: Based on a classification scheme(1), Koc values of 345(2) to 800(3) indicate that cycloate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is(4) based upon an estimated Henry's Law constant of 5.2X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 1.57X10-3 mm Hg(5), and water solubility, 85 mg/L(6). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 8 days and 64 days, respectively(SRC). According to a classification scheme(7), an estimated BCF of 190(SRC), from its log Kow of 3.88(8) and a regression-derived equation(9), suggests the potential for bioconcentration in aquatic organisms is high, provided the compound is not metabolized by the organism(SRC). Cycloate is stable to hydrolysis and photolysis in water(3). 14C-labeled cycloate was up to 90% mineralized using a continuous flow-through system and soil inoculum(10), indicating that biodegradation is an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cycloate, which has a vapor pressure of 1.57X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase cycloate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 10 hrs(SRC), calculated from its rate constant of 3.53X10-11 cu cm/molecule-sec at 25 degC(3). Photodegradation of cycloate was observed in hexane, following exposure to UV light(4). Dipropylamine, ethyl mercaptan, and ethyl disulfide were identified as photolysis products(4). Therefore, cycloate may be susceptible to direct photolysis by sunlight(SRC). A photolysis half-life in air of 5.2 hrs has been reported(5). |
| Expositionspfade | Inhalation (L793)oral (L793)dermal (L793) |
| Milk Concentrations | Two lactating goats were dosed twice daily (after the morning milking and after the evening milking) via balling gun with gelatin capsules containing uniformly ring-labeled (13)C/(14)C-cycloate for four consecutive days at 23 ppm. This dose rate represents approximately 88x the maximum theoretical dietary exposure for lactating ruminants ... . During the treatment period, milk was collected twice daily. The goats were sacrificed 14-16 hours after the final dosing and samples were stored frozen for up to 5 months prior to residue analysis. The total radioactive residues (TRRs) (expressed as cycloate equivalents) in the tissues of the goat used for residue characterization and identification were: 2.86 ppm in liver, 0.48 ppm in kidney, 0.05 ppm in muscle, and 0.01 ppm in fat. The TRR in milk ranged from 0.10 to 0.13 ppm. ... TRR in muscle and fat were low (< or = 0.05 ppm) ... |
| Toxizitätsübersicht | Some thiocarbamates (EPTC, Molinate, Pebulate, and Cycloate) share a common mechanism of toxicity, i.e. the inhibition of acetylcholinesterase. An acetylcholinesterase inhibitor suppresses the action of acetylcholine esterase. Because of its essential function, chemicals that interfere with the action of acetylcholine esterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses. Headache, salivation, nausea, vomiting, abdominal pain and diarrhea are often prominent at higher levels of exposure. Acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop. |
| Ökotoxizitätsauszüge | /BIRDS and MAMMALS/ The acute oral toxicity to birds is (1) Northern bobwhite (Colinus virginianus), product 98.6% a.i.LD50 >2150 mg/kg, practically nontoxic (2) Redwing Blackbirdtechnical productLD50 >100 mg/kg, no more than moderately toxic and (3) StarlingLD50 >100 mg/kg, no more than moderately toxic /From table/. Since the LD50 falls in the range of >100 mg/kg to >2150 mg/kg, /EPA considers that/ cycloate is no more than moderately toxic to avian species on an acute oral basis./BIRDS and MAMMALS/ Two subacute dietary studies using the technical grade active ingredient (TGAI) were required to establish the toxicity of cycloate to birds. The following information was submitted: (1) Northern bobwhite quail (Colinus virginianus)TGAI 96.8%5-day LC50 >5620, practically non-toxic (2)Northern bobwhite quail (Colinus virginianus)TGAI 73.9%5 day LC50 >56,000 (8 day5 day plus 3 day observation after exposure) practically non-toxic (3) Mallard duck (Anas platyrhynchos)TGAI 98.6%5 day LC50 >10,000 (8 day5 day exposure followed by 3 day observation period), practically non-toxic (4) Mallard duck (Anas platyrhynchos)5 day LC50 >5395, practically non-toxic /From table//AQUATIC SPECIES/ LC50 values for freshwater fish falls in the range from 2.6 to 10.5 ppm ai, therefore, cycloate is considered moderately toxic to freshwater fish on an acute basis./OTHER TERRESTRIAL SPECIES/ ...The mobility of freshwater snails Physa and Lymnaea was diminished in the presence of ... cycloate (thiocarbamate) ... ./OTHER TERRESTRIAL SPECIES/ Honey bee (Apis mellifera)73.9% a.i.LD50 29.01ug/bee, judged by EPA as practically non-toxic. |
| Signs and Symptoms | As with organophosphates, the signs and symptoms are based on excessive cholinergic stimulation. Unlike organophosphate poisoning, carbamate poisonings tend to be of shorter duration because the inhibition of nervous tissue acetylcholinesterase is reversible, and carbamates are more rapidly metabolized. Muscle weakness, dizziness, sweating and slight body discomfort are commonly reported early symptoms. Headache, salivation, nausea, vomiting, abdominal pain and diarrhea are often prominent at higher levels of exposure. Contraction of the pupils with blurred vision, incoordination, muscle twitching and slurred speech have been reported. (L795) |
| Soil Adsorption/Mobility | The Koc of cycloate has been experimentally determined to be 345(1,2). The compound tends to sorb to soil under dry conditions and is not reversed if soil is later flooded(3). If already flooded, then cycloate desorbs readily and then volatilizes. Koc values of 500-800 have been reported(3). According to a classification scheme(4), these Koc values suggest that cycloate is expected to have moderate mobility in soil. Cycloate was found at a maximum depth of 6-9 inches in a leaching study using four different soils(5).Koc 600 and Kd 9 for adsorption, and Koc 767 and Kd 11.5 for desorption in a silt loam with 1.5% organic matterKoc 500 and Kd 10 for adsorption, and Koc 615 and Kd 12.3 for desorption in a loam with 2% organic matterKoc 545 and Kd 2.18 for adsorption, and Koc 745 and Kd 2.87 for desorption in a sandy loam with 0.4% organic matterKoc 678 and Kd 8.13 for adsorption, and Koc 803 and Kd 9.63 for desorption in a clay loam with 1.2% organic matter |
| Human Toxicity Excerpts | /GENOTOXICITY/ In a mammalian cell cytogenetics assays (chromosome aberration) ... human lymphocytes, derived from one male and one female healthy donors were exposed in culture to cycloate (98.1% ai ... ), in dimethyl sulfoxide (DMSO) for 3 hours at doses of 0, 10, 50 or 100 ug/mL with and without metabolic activation (both donors). The S-9 homogenate was derived from the livers of Aroclor 1254-induced Alpk:APf Sprague-Dawley rats. Cycloate was cytotoxic, causing a > or = 30% reduction in the mitotic index (MI) at 100 ug/mL without S-9 and an = 15% reduction in the MI at 100 ug/mL with S-9 (both donor cells). In preliminary testing, few, if any metaphases were observed at 150 ug/mL and levels > or = 200 ug/mL were insoluble. The positive controls induced the expected clastogenic responses. There was, however, no indication that cycloate induced an increase in structural chromosome aberrations at any concentration. /98.1%/ |
| Artificial Pollution Sources | Cycloate's production may result in its release to the environment through various waste streamsits use as a herbicide(1) will result in its direct release to the environment(SRC). |
| Landesrichtlinien für Trinkwasser | (FL) FLORIDA 35 ug/L |
| Wassergefährdungsklasse (WGK) | 2 |
| UN-Transportnummer | UN3082 9/PG 3 |
| RTECS-Nr. | GU7200000 |
| R-Sätze (R) | 22-51/53 |
| Toxizität | LC50 (96-hour) for rainbow trout 4.5 mg/L (Hartley and Kidd, 1987), for mosquito fish 10 ppm (Humburg et al., 1989)acute oral LD50 of technical cycloate for male and female rats 2,000–3,190 and 3,160–4,100 mg/kg, respectively (Hartley and Kidd, 1987), 1,678 mg/kg (RTECS, 1985) |
| Gefahrensymbole | Xn,N |
| Sicherheitshinweise (S) | 61 |
| Lagerklasse | 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects |
| Gefahrstoffdaten | 1134-23-2(Hazardous Substances Data) |
| Gefahrenklasse | Acute Tox. 3 InhalationAquatic Chronic 2 |
Anwendungen & Verwendung
Verwenden
Herbicide used to control several broad-leaved weeds and many annual grasses in sugar beets, table beets and spinach