HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2'-(4'-Ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bis-1H-benzimidazoltrihydrochloridtrihydrat
33342 · hoescht 33342 · ho342 · H33342 · HOE 33342 · Hoest 33342 · Hoechst®HOECHST 33342 · HOE-33342 3HCL
Identifikatoren & physikalische Daten
| CAS No. | 23491-52-3 |
|---|---|
| Summenformel | C27H28N6O |
| Durchschnittliche Molmasse | 452,6 g/mol |
| Monoisotopische Masse | 452,23245954 g/mol |
| SMILES | CCOc1ccc(-c2nc3ccc(-c4nc5ccc(N6CCN(C)CC6)cc5[nH]4)cc3[nH]2)cc1 |
| InChIKey | PRDFBSVERLRRMY-UHFFFAOYSA-N |
| PubChem CID | 1464 |
| ChEMBL | CHEMBL343002 |
| ChEBI | CHEBI:51232 |
| EC No. | 245-691-1 |
| DTXSID | DTXSID80178059 |
| Lokaler Name | 2'-(4'-Ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bis-1H-benzimidazoltrihydrochloridtrihydrat |
Chemische & physikalische Eigenschaften
| XLogP | 4,6 |
|---|---|
| Polarare Oberfläche (TPSA) | 73,1 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 5 |
| Frei drehbare Bindungen | 5 |
| Schwere Atome | 34 |
| Formalladung | 0 |
| Komplexität | 664 |
| Physical Description | Yellow-green powder[Acros Organics MSDS] |
| Siedepunkt | 725.9±70.0 °C(Predicted) |
| Dichte | 1.274±0.06 g/cm3(Predicted) |
| Lagerbedingungen | 2-8°C |
| Löslichkeit | H2O: soluble20mg/mLWater : 1 mg/mL (2.21 mMultrasonic and warming and heat to 80°C) |
| Aggregatzustand | Yellow solid |
| pKa (Säurekonstante) | 10.97±0.10(Predicted) |
| Farbe | Brown to breen |
| BRN | 1234011 |
| InChIKey | PRDFBSVERLRRMY-UHFFFAOYSA-N |
| SMILES | C1(C2C=C3NC(C4=CC=C(OCC)C=C4)=NC3=CC=2)NC2=CC(N3CCN(C)CC3)=CC=C2N=1 |
| CAS Datenbank | 23491-52-3(CAS DataBase Reference) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]H315 (97.7%): Causes skin irritation [Warning Skin corrosion/irritation]H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]H341 (90.7%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]P203, P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P318, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 43 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatorische Informationen | 2,5'-Bi-1H-benzimidazole, 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-: Does not have an individual approval but may be used under an appropriate group standard |
| Gefahrenübersicht | May cause irritation[Acros Organics MSDS] See Bisbenzimidazole trihydrochloride. |
| Hazard Classes and Categories | Acute Tox. 4 (100%)Skin Irrit. 2 (97.7%)STOT SE 3 (100%)Muta. 2 (90.7%) |
| F | 3-8-10 |
| Wassergefährdungsklasse (WGK) | 3 |
| Zollcode | 32129000 |
| RTECS-Nr. | DT4200000 |
| R-Sätze (R) | 22-37/38-36/37/38-20/21/22-37-35 |
| Toxizität | dni-hmn-hla 300 nmol/L CRNGDP 13,2389,1992 |
| Gefahrensymbole | Xn,C |
| Sicherheitshinweise (S) | 22-36/37-24/25-36-26-45-36/37/39 |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Verwenden
Hoechst 33342 is useful for staining DNA, chromosomes and nuclei. May be used for fluorescence microscopy or flow cytometry. Suitable for vital DNA staining of a variety of cell types and as a probe of membrane permeability in mammalian cells.