Karminsure
CI 75470 · E120 · CARMINE RED · coccinic acid · CARMINE ALUMINUM LAKE · Carminic · C.I.Naturalred4 · NSC 326224
Identifikatoren & physikalische Daten
| CAS No. | 1260-17-9 |
|---|---|
| Summenformel | C22H20O13 |
| Durchschnittliche Molmasse | 492,4 g/mol |
| Monoisotopische Masse | 492,09039069 g/mol |
| SMILES | Cc1c(C(=O)O)c(O)cc2c1C(=O)c1c(O)c([C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(O)c(O)c1C2=O |
| InChIKey | DGQLVPJVXFOQEV-NGOCYOHBSA-N |
| PubChem CID | 14749 |
| ChEMBL | CHEMBL1366408 |
| EC No. | 215-724-4 |
| Lokaler Name | Karminsure |
Chemische & physikalische Eigenschaften
| XLogP | 0,5 |
|---|---|
| Polarare Oberfläche (TPSA) | 243 |
| H-Brücken-Donoren | 9 |
| H-Brücken-Akzeptoren | 13 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 35 |
| Formalladung | 0 |
| Komplexität | 864 |
| Physical Description | Red crystals in methanolbright red powderdeep red color in water[HSDB] |
| Schmelzpunkt | 136 °C |
| Siedepunkt | 506.2°C (rough estimate) |
| Dichte | 1.4504 (rough estimate) |
| Brechungsindex | 1.6000 (estimate) |
| Flammpunkt | 12℃ |
| Lagerbedingungen | room temp |
| Löslichkeit | 30g/l1.298g/L(room temperature) |
| Aggregatzustand | Crystalline Powder |
| pKa (Säurekonstante) | 1.62±0.20(Predicted) |
| Farbe | Red to dark red |
| pH | 1.6 (10g/l, H2O, 20℃) |
| Geruch | Odorless |
| Merck | 14,1843 |
| BRN | 71651 |
| Hauptanwendungen | diagnostic assay manufacturinghematologyhistology |
| InChIKey | DGQLVPJVXFOQEV-JNVSTXMASA-N |
| SMILES | Cc1c(C(O)=O)c(O)cc2C(=O)c3c(O)c(O)c([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c(O)c3C(=O)c12 |
| LogP (Verteilungskoeffizient) | 1.532 (est) |
| CAS Datenbank | 1260-17-9 |
| EPA chemische Informationen | C.I. Natural Red 4 (1260-17-9) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 100% (298 of 298) of all reports.Not ClassifiedReported as not meeting GHS hazard criteria by 298 of 298 companies. For more detailed information, please visit ECHA C&L website.Aggregated GHS information provided per 298 reports by companies from 1 notifications to the ECHA C&L Inventory.Reported as not meeting GHS hazard criteria per 298 of 298 reports by companies.There are 0 notifications provided by 0 of 298 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatorische Informationen | Chemical: CarmineStatus: Active Update: 13-04-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/28382Carmine: Does not have an individual approval but may be used under an appropriate group standard |
| Gefahrenübersicht | Anthraquinones are toxic by ingestion and may cause vomiting, diarrhea, kidney and liver damage, and comaDeaths have been reported after children ingested Rhamnus berries[HSDB] Occupational asthma confirmed in workers in dye manufacturing plant[Malo] Cochineal is the dried bodies of the female insect coccus cacti. Carminic acid is the active coloring material, and carmine is the aluminum lake of carminic acid. [HSDB] See Carminic acid and Cochineal. |
| Hazard Classes and Categories | Not Classified |
| Unerwünschte Wirkungen | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents. |
| Wassergefährdungsklasse (WGK) | 2 |
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 32129000 |
| Sicherheitshinweise (S) | 22-24/25 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrstoffdaten | 1260-17-9(Hazardous Substances Data) |
Anwendungen & Verwendung
History
CI Natural Red 4(CI 75470), is a red dye occurring as a glycoside in the body of the cochineal insect Dactylopius coccus of the order Homoptera, family Coccidae. This insect is native to Central and South America. The Aztecs had extracted the dye from the insect centuries before the coming of the Spaniards. For breeding purposes, the insects were collected in the autumn and carefully protected during the winter months. Cochineal was harvested after three months, and then the bugs were killed by immersion in hot water, by placing in hot ovens, or by exposure to the hot sun. The latter method produced the highest quality dye. At present, Peru and the Canary Islands are the main source of the dye. Until the advent of synthetic dyes, the principal use for carminic acid was for dyeing tin-mordanted wool or silk. Its aluminum lake, carmine, finds use in the coloring of foods.
Verwenden
Carminic acid (C.I. 75470) For staining nuclei in histological sections. Used to prepare staining solutions. CAS 1260-17-9, pH 1.6 (10g/l, HO, 20°C).