Diarsenpentoxid

Isolate hazard area and deny entry. Stay upwind; keep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing.

In case of fire in the surroundings, use appropriate extinguishing media.

- Arsenic pentoxide is non-combustible; the substance itself does not burn, but it may decompose upon heating to produce corrosive and/or toxic fumes.

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.

Rinse mouth. Refer immediately for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

Warning: Effects usually appear within 30 minutes of exposure but may be delayed for several hours. Caution is advised.

General First Aid:

· Wear positive pressure self-contained breathing apparatus (SCBA).

Biological Exposure Indices (BEI) [ACGIH] - Inorganic arsenic plus methylated metabolites in urine = 35 ug As/L; end of workweek;

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical, or carbon dioxide.

Use flooding quantities of water as spray. Control runoff and isolate discharge material for proper disposal. Extinguish fire using agent suitable for surrounding fire.

Personnel protection: ... Wear appropriate chemical protective clothing. ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material.

Store in tightly-closed containers in a cool, well-ventilated area away from metals, acids and other incompatible materials.

Protect container against physical damage. Store in well ventilated area away from food or food products and combustible materials. /Inorganic arsenic cmpd/

Separate from acids, halogens, aluminum, and zinc. Store in a cool, dry, well-ventilated location.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a POTW is acceptable only after review by the governing authority. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must meet Hazardous Material Criteria for disposal.

Personal precautions: Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

Prompt cleanup and removal are necessary.

Floors and other accessible surfaces contaminated with inorganic arsenic may not be cleaned by the use of compressed air, and shoveling and brushing may be used only where vacuuming or other relevant methods have been tried and found not to be effective. /Inorganic arsenic compounds/

For more Cleanup Methods (Complete) data for ARSENIC PENTOXIDE (6 total), please visit the HSDB record page.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P011, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.[

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D004, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste. /Arsenic/[

Dissolve in a minimum of concentrated hydrochloric acid. Dilute with water until white precipitate forms. Add HCl to dissolve. Saturate with H2S; filter and wash precipitate and return to supplier. Alternatively, precipitate with heavy metals such as lime or ferric hydroxide in lieu of H2S...

For more Disposal Methods (Complete) data for ARSENIC PENTOXIDE (9 total), please visit the HSDB record page.

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Store and dispose of according to local regulations.

The mean, median and range concentration of inorganic arsenic in 23 urine samples from individuals handling products containing arsenic pentoxide were 23.4, 19.5 and 11.5 to 48.4 As/mmol creatinine, respectively(1). The mean and range concentration of inorganic arsenic, which includes arsenic (V) is 2-91 ug/L urine from a Hawaiian study population. Among residents of a West Bengal, India region inflicted with blackfoot disease, As(V) accounted for 21.5% of total arsenic species in fingernail samples(2).

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

LC50; Species: Cancer magister (Dungeness or edible crab); Conditions: saltwater, static, 15 °C, pH 8.1, salinity 33.79%, dissolved oxygen 6.5-8.0 mg/L; Concentration: 232 ug/L for 24 hr

LC50; Species: Morone saxatilis (Striped bass) age 63 days; Conditions: freshwater, static, 20 °C, hardness 475 mg/L CaCO3; Concentration: 30500 ug/L for 96 hr (95% confidence interval: 21292-43690 ug/L)

LC50; Species: Morone saxatilis (Striped bass) age 63 days; Conditions: freshwater, static, 20 °C, hardness 285 mg/L CaCO3; Concentration: 40500 ug/L for 96 hr (95% confidence interval: 32022-51223 ug/L)

LC50; Species: Morone saxatilis (Striped bass) weight 1.8 g; Conditions: saltwater, static, 25 °C, pH 8.12, hardness 4430 mg/L CaCO3, salinity 22.5 ppt, alkalinity 88 mg/L CaCO3; Concentration: 10300 ug/L for 96 hr (95% confidence interval: 6400-13500 ug/L)

For more Ecotoxicity Values (Complete) data for ARSENIC PENTOXIDE (7 total), please visit the HSDB record page.

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Arsenic pentoxide is readily absorbed into the body via ingestion, inhalation, and through mucosal membranes. Unless it is mixed with a solvent to enhance absorption, arsenic pentoxide is minimally absorbed through intact skin. Arsenic pentoxide can be absorbed through broken skin. Eye exposure to arsenic pentoxide can cause irritation, but it is not associated with systemic toxicity.

Oral (L2) ; inhalation (L2); dermal (L2)

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

/PLANTS/ This manuscript reports the toxic effects of As2O3 (arsenic trioxide) and As2O5 (arsenic pentoxide) on S. kali as well as the arsenic and phosphate uptake and arsenic coordination within plant tissues. Plants were germinated and grown for 15 days on a Hoagland-modified medium containing either As(III) (arsenic trioxide) or As(V) (arsenic pentoxide). Subsequently, the seedlings were measured and analyzed using inductively coupled plasma optical emission spectroscopy and X-ray absorption spectroscopy techniques. Plants stressed with 2 mg/L of whichever As(III) or As(V) concentrated 245 +/- 19, 30 +/- 1, and 60 +/- 3 mg As /kg dry weight or 70 +/- 6, 10 +/- 0.3, and 27 +/- 3 mg As/kg dry weight in roots, stems, and leaves, respectively. Arsenate was less toxic, and more As translocation occurred from the roots to the leaves. All treatments reduced P concentration at root level; however, only As(V) at 2 and 4 mg/L reduced P concentration at leaf level. Regardless the arsenic species supplied to the plants, arsenic was found in plant tissues as As(III) coordinated to three sulfur ligands with an interatomic distance of approximately 2.25 angstroms.

Cough. Sore throat. Headache. Dizziness. Weakness. Shortness of breath. Chest pain. See Ingestion.

Redness. Burning sensation. Pain.

Redness. Pain.

Vomiting. Abdominal pain. Diarrhoea. Severe thirst. Muscle cramps. Shock or collapse. Symptoms may be delayed.

- Arsenic pentoxide dust causes eye irritation, itching, burning, mild temporary redness and/or inflammation of the eye membrane (conjunctivitis), watering (lacrimation), temporary double vision (diplopia), abnormal sensitivity to light (photophobia), vision dimness, and other transient eye damage or lesion formation (ulceration).

- The classic presentation of arsenic pentoxide toxicity revolves around the gastrointestinal symptoms described in Signs/Symptoms, General. Other signs and symptoms include fluid in the lungs (pulmonary edema), adult respiratory distress (ARS), toxic delirium, pain in the extremities and muscles, absence of urination (anuria), blood and protein in the urine (hematuria and proteinuria), tissue swelling in the extremities (peripheral edema), headache, loss of appetite (anorexia), and vertigo. Skin findings are uncommon but may include flushing and sweating (diaphoresis). Severe toxicity may cause respiratory failure, kidney damage and failure, cellular liver damage (hepatocellular damage), and mania.

/SIGNS AND SYMPTOMS/ In man, symptoms of acute inorganic arsenic poisoning occurring as consequence of ... ingestion consist of burning & dryness of oral & nasal cavities, GI disturbance, & muscle spasms; vertigo, delirium, & coma may occur. Edema of face & about eyelids may also be evident. Chronic arsenic intoxication is characterized by malaise & fatigue, GI disturbances, hyperpigmentation & peripheral neuropathy may ultimately occur. Pale bands on fingernails & toes may develop. Clinical pathology may reveal anemia (slightly hypochromic) and basophilic stippling. Red cell disruption, decr red cell production, and leukopenia are frequently observed /from chronic exposure/. /Arsenic/

/SIGNS AND SYMPTOMS/ Arsenic pentoxide is capable of producing skin sensitization and contact dermatitis. Arsenic is also capable of producing keratoses, especially on the palms and soles.

/SIGNS AND SYMPTOMS/ Within minutes to hours following arsenic pentoxide ingestion the patient/victim may experience nausea, vomiting, abdominal pain, and "rice water" like diarrhea. Patient/victims suffering from less severe arsenic pentoxide toxicity may experience the following adverse health effects: Gastrointestinal: Metallic taste or irritation of the top of the mouth and back of the throat (oropharynx) and inflammation of the pharynx (pharyngitis). Persistent inflammation of the stomach lining (gastroenteritis) with possible ulcerative lesions and bleeding (hemorrhage). Dermal: toxic inflammation and redness of the skin (erythroderma) with skin shedding (exfoliative dermatitis) may result from a hypersensitivity reaction to arsenic pentoxide. Mild low blood pressure (hypotension).

/SIGNS AND SYMPTOMS/ ... Patients/victims suffering from severe arsenic pentoxide intoxication may experience the following multisystem adverse health effects: Cardiovascular: heart rate disturbances (sinus tachycardia and ventricular dysrhythmias), low blood pressure caused by change in position (orthostatic hypotension), shock, heart (myocardial) dysfunction, false heart attack (mimicked myocardial infarction), and loss of circulating blood volume (hypovolemia) from leaking capillaries. Central nervous system: acute degenerative disease or dysfunction of the brain (encephalopathy) may develop and progress over several days, delirium, and confusion. Seizures may be caused by brain swelling (cerebral edema) and brain vessel bleeding (microhemorrhages). Seizures and fainting (syncope) may be caused by heart rate irregularities as opposed to being primarily neurological. Respiratory system: accumulation of fluid in the lungs (pulmonary edema), acute respiratory distress syndrome (ARDS), and respiratory failure. Liver (hepatic): inflammation of the liver (hepatitis). Kidney (renal): acute kidney (renal) failure due to low blood pressure (hypotension), deposition of muscle or blood proteins in the kidneys (tubular deposition of myoglobin or hemoglobin), or direct kidney toxicity. Fever. Unusual complications: injury to the nerve supply of the diaphragm and larynx (phrenic nerve paralysis), paralysis of muscles on one side of the face (unilateral facial nerve palsy), inflammation of the pancreas (pancreatitis), and inflammation of the lining surrounding the heart and lungs (pericarditis and pleuritis).

Arsenic pentoxide's production and use in the manufacture of colored glass, arsenates, in adhesives for metals(1) and in dyeing and printing(2) may result in its release to the environment through various waste streams. Its use as in wood preservatives, in weed control, and as a fungicide(1,2) will result in its direct release to the environment(SRC).

Tolerances for total residues of combined arsenic (calculated as As) in food are established as follows: (a) In edible tissues and in eggs of chickens and turkeys: (1) 0.5 part per million in uncooked muscle tissue. (2) 2 parts per million in uncooked edible by-products. (3) 0.5 part per million in eggs. (b) In edible tissues of swine: (1) 2 parts per million in uncooked liver and kidney. (2) 0.5 part per million in uncooked muscle tissue and by-products other than liver and kidney. /Arsenic/

P011; As stipulated in 40 CFR 261.33, when arsenic pentoxide, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to federal and/or state hazardous waste regulations. Also defined as a hazardous waste is any container or inner liner used to hold this waste or any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5(e)).

D004; A solid waste containing arsenic may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. /Arsenic/

Section 4(g)(2)(A) of FIFRA calls for EPA to determine, after submission of relevant data concerning an active ingredient, whether or not products containing the active ingredient are eligible for reregistration. EPA has previously identified and required the submission of the generic (i.e., active ingredient-specific) data required to support reregistration of wood preservative products containing arsenic and/or chromium as active ingredients. The Agency has reviewed these generic data, and has determined that the data are sufficient to support a reregistration eligibility decision for the wood preservative uses of chromated arsenicals (see Appendix B). EPA considered the available information and, after a thorough evaluation of the risks and benefits associated with each use, has determined that the wood preservative uses of chromated arsenicals presented in Appendix A will not pose unreasonable risks to humans or the environment provided that (1) all risk mitigation measures are implemented, (2) label amendments are made as described in Section V, and (3) current data gaps and confirmatory data needs are addressed. Accordingly, should a registrant fail to implement any of the requirements for reregistration identified in this document, the Agency may take regulatory action to address the potential risk concerns from the use of chromated arsenicals. /Case includes arsenic pentoxide/

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Arsenic pentoxide is found on List A, which contains most pesticides that are used on foods and, hence, have a high potential for human exposure. List A consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA '88. Case No: 0132; Pesticide type: fungicide (wood perservative); Registration Standard Date: 6/1/88, 9/10/86; Case Status:/Office of Pesticide Programs/ (OPP) is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the RED document.; Active ingredient (AI): arsenic pentoxide; Data Call-in (DCI) Date(s): 1/31/94; AI Status: The producers of the pesticide has made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Arsenic pentoxide is included on this list.

Inorganic arsenic has been designated as a hazardous air pollutant under section 112 of the Clean Air Act. /Inorganic Arsenic/

Emission limits. (a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/

Emission limits. (b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/

For more Atmospheric Standards (Complete) data for ARSENIC PENTOXIDE (7 total), please visit the HSDB record page.

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Arsenic pentoxide is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 100 or 10,000 lbs. Extremely hazardous substances that are solids are subject to either of two threshold planning quantities ... The lower quantity applies only if the solid exists in powdered for and has a particle size less than 100 microns; or is handled in solution or in molten form; or meets the criteria for a National Fire Protection Association (NFPA) rating of 2, 3 or 4 for reactivity. If the solid does not meet any of these criteria, it is subject to the upper ... threshold planning quantity ... .

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1 lb or 0.454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Arsenic pentoxide is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.

For the maximum protection of human health from the potential carcinogenic effects due to exposure of arsenic through ingestion of contaminated water & contaminated aquatic organisms, the ambient water concn should be zero based on the nonthreshold assumption for this chemical. However, zero level may not be attainable at the present time. Therefore, the levels which may result in incremental increase of cancer risk over the lifetime are estimated at 1X10-5, 1X10-6, & 1X10-7. The corresponding criteria are 22 ng/L, 2.2 ng/L, & 0.22 ng/L, respectively .... For consumption of aquatic organisms only, excluding consumption of water, the levels are 175 ng/mL, 17.5 ng/L, & 1.75 ng/L, respectively. /Arsenic/

Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Arsenic and compounds/

(AZ) ARIZONA 10 ug/L /Arsenic/

(CT) CONNECTICUT 10 ug/L /Arsenic/

10 ug/L /Arsenic/

Maximum Contaminant Level: 0.010 mg/L /Arsenic/