Diquafosol Tetrasodium

HCID 148196CAS 211427-08-6
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Grundinformationen

Standard-SMILES
O=c1ccn([C@@H]2O[C@H](COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1.[Na+].[Na+].[Na+].[Na+]
InChIKey
OWTGMPPCCUSXIP-FNXFGIETSA-J
Summenformel
C18H22N4Na4O23P4
Durchschnittliche Molmasse
878,2 g/mol

Überblick

See also: Diquafosol (has active moiety).

Namen und Bezeichner

Bevorzugter Name
Diquafosol Tetrasodium
IUPAC
tetrasodium;[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate
Englischer Name
Diquafosol Tetrasodium
Summenformel
C18H27N4NaO23P4
Molmasse
814.3

Namen und Synonyme

Diquafosol tetrasodiumIns 365Diquafosol sodiumDiquafosol tetrasodium saltINS365X8T9SBH9LLKPY-998DE-089Diquafosol tetrasodium [USAN]Diquafosol sodium (JAN)UNII-X8T9SBH9LLDiquafosol tetrasodium (USAN)
Weitere Namen anzeigen
D03864CID 9876095DiquafosoftetrasodiumDexamethoxol tetrasodiumDiquafosol Tetrasodium CRS
DIQUAFOSOL SODIUM [JAN]Uridine(5')tetraphospho(5')uridine tetrasodium saltDIQUAFOSOL TETRASODIUM [MART.]DIQUAFOSOL TETRASODIUM [WHO-DD]DIQUAFOSOL TETRASODIUM SALT [MI]P1,P4-Diuridine 5'-tetraphosphate tetrasodium saltDIQUAFOSOL TETRASODIUM (MART.)Uridine 5'-(pentahydrogen tetraphosphate), P'''-5'ester with uridine, tetrasodium salt

Datenbank-Bezeichner

CAS
211427-08-6
PubChem CID
148196
ChEMBL
CHEMBL1767408
UNII
X8T9SBH9LL

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
405 Ų
H-Brücken-Donoren
6
H-Brücken-Akzeptoren
23
Frei drehbare Bindungen
14
Schwere Atome
53

Physikochemische Eigenschaften

storage temp.
-20 °C · Store at -20°C
Löslichkeit
1 · DMSO:1.0(Max Conc. mg/mL);1.14(Max Conc. mM)Water:100.0(Max Conc. mg/mL);113.86(Max Conc. mM)
Aggregatzustand
A solid
Farbe
White to off-white
Wasserlöslichkeit
2 O: · H2O: 2mg/mL, clear
InChIKey
XPZQVLUPTGTIJP-NIBQMMLDNA-N

Sicherheit und Regulatorisches

Sicherheitsdaten

wgk
WGK 3
Speicherklasse
11 - Combustible Solids

Chemie und Industrie

Anwendungen · 2 Einträge

BeschreibungDiquafosol (INS-365) was approved in Japan in 2010 as a 3% ophthalmic solution for treatment of dry eye disease. Clinical diagnosis of dry eye is difficult because the condition presents a variety of symptoms. Treatment options include tear supplements (lubricants), anti-inflammatory drugs (e.g., cyclosporine eye drops or steroid eye drops), and tear retention devices. Diquafosol is a unique agent for the treatment of dry eye in that it acts as a P2Y2 purinergic receptor agonist with the ability to activate this receptor on the ocular surface and stimulate water, lipid, and mucin secretion. Diquafosol is metabolized by phosphodiesterases to UTP, UDP, UMP, and uridine. Diquafosol has been well tolerated in clinical trials, with side effects being local to the ocular surface.In addition,no serious ocular or systemic adverse drug reactions were found during the clinical trials.

VerwendenEnhancement of mucosal hydration in the treatment of chronic dry eye (P2Y2 receptor antagonist).

Anbieter50 Anbieter

湖北威德利化学试剂有限公司181-6332-1995 18062128043 · [email protected]
济南百隆化学有限公司[email protected] · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
福建华耀医药科技有限公司18559985626 · [email protected]

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