Identifikatoren & physikalische Daten
| CAS No. | 1317-38-0 |
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| Summenformel | CuO |
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| Durchschnittliche Molmasse | 79,55 g/mol |
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| SMILES | [O]=[Cu] |
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| InChIKey | QPLDLSVMHZLSFG-UHFFFAOYSA-N |
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| PubChem CID | 14829 |
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Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 17,1 |
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| H-Brücken-Donoren | 0 |
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| H-Brücken-Akzeptoren | 1 |
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| Frei drehbare Bindungen | 0 |
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| Schwere Atome | 2 |
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| Formalladung | 0 |
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| Komplexität | 2 |
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| Pestizide | Agrochemicals -> Pesticide active substancesActive substance -> EU Pesticides database: Approved |
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Sicherheit & Vorschriften
| Regulatorische Informationen | 2009/37/EC, Reg. (EU) 2020/1093, Reg. (EU) No 2018/1981, Reg. (EU) No 232/2015, Reg. (EU) No 540/2011, Reg.(EU) No 84/2018 |
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| Minimum Risk Level | Acute Oral: 0.01 mg/kg/day (L134)
Intermediate Oral: 0.01 mg/kg/day (L134) |
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| Treatment | EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration. |
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| Gesundheitliche Auswirkungen | People must absorb small amounts of copper every day because copper is essential for good health, however, high levels of copper can be harmful. Very-high doses of copper can cause damage to your liver and kidneys, and can even cause death. Copper may induce allergic responses in sensitive individuals. (L278, L279) |
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| Expositionspfade | Oral (L277)inhalation (L277)dermal (L277) |
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| Toxizitätsübersicht | Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes become saturated and copper accumulates in the nucleus, causing nuclear damage. This damage is possibly a result of oxidative damage, including lipid peroxidation. Copper inhibits the sulfhydryl group enzymes such as glucose-6-phosphate 1-dehydrogenase, glutathione reductase, and paraoxonases, which protect the cell from free oxygen radicals. It also influences gene expression and is a co-factor for oxidative enzymes such as cytochrome C oxidase and lysyl oxidase. In addition, the oxidative stress induced by copper is thought to activate acid sphingomyelinase, which lead to the production of ceramide, an apoptotic signal, as well as cause hemolytic anemia. Copper-induced emesis results from stimulation of the vagus nerve. (L277, T49, A174, L280) |
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| Signs and Symptoms | Breathing high levels of copper can cause irritation of the nose and throat. Ingesting high levels of copper can cause nausea, vomiting, diarrhea, headache, dizziness, and respiratory difficulty. (L278, L279) |
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| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
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| Toxicity Data | LD50: 470 mg/kg (Oral, Rat) (L333)
LD50: 273 mg/kg (Intraperitoneal, Mouse) (L333) |
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