[Ethan-1,2-diylbis[nitrilobis(methylen)]]tetrakisphosphonsure

Ethylenediaminetetra(methylenephosphonic acid)

HCID 15025CAS 1429-50-1
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Grundinformationen

Standard-SMILES
O=P(O)(O)CN(CCN(CP(=O)(O)O)CP(=O)(O)O)CP(=O)(O)O
InChIKey
NFDRPXJGHKJRLJ-UHFFFAOYSA-N
Summenformel
C6H20N2O12P4
Durchschnittliche Molmasse
436,12 g/mol
Monoisotopische Masse
435,9966706

Überblick

Lexidronam is a phosphonate analog of ethylenediaminetetraacetic acid (EDTA), with chelating activity. Lexidronam binds to and associates with hydroxyapatite crystals concentrated in areas of bone turnover. It has been used as a radiopharmaceutical in complexes with radioactive metals to selectively deliver cytotoxic radiation to osteoblastic bone metastases.

Namen und Bezeichner

Bevorzugter Name
Ethylenediaminetetra(methylenephosphonic acid)
IUPAC
[2-[bis(phosphonomethyl)amino]ethyl-(phosphonomethyl)amino]methylphosphonic acid
Lokaler Name
[Ethan-1,2-diylbis[nitrilobis(methylen)]]tetrakisphosphonsure
Englischer Name
Ethylenebis(nitrilodimethylene)tetraphosphonic acid
Summenformel
C6H20N2O12P4
Molmasse
436.12

Namen und Synonyme

1429-50-1LexidronamEthylenediaminetetra(methylenephosphonic acid)V4CP8RSX7VBRIQUEST 422-25SDTXSID3061689EDTPO(Ethylenedinitrilo)-tetramethylenephosphonic acidEthylenediamine tetra(methylene phosphonic acid)PH540Ethylenediamine tetrakis(methylene phosphonic acid)PH-540
Weitere Namen anzeigen
edtmpMethylene Phosphonic AcidETHYLENEDIAMINE TETRA(METHYLENEPHOSPHONIC ACID)EDTMPS·Na8sandeqingxiDequest 2041EDTMP, EDTMPAtetrakis(methylene)
Phosphonic acid, (1,2-ethanediylbis(nitrilobis(methylene)))tetrakis-editempaeditempa acid68Ga-EDTMPRefChem:406469DTXCID9034654ethylenediaminetetra(methylenephosphonic)acidN,N,N',N' ethylenediamine tetra(methylenephosphonic acid)

Datenbank-Bezeichner

CAS
1429-50-1、15142-96-8、22036-77-7、61827-49-4
PubChem CID
15025
DTXSID
DTXSID3061689
ChEMBL
CHEMBL1208647
UNII
V4CP8RSX7V
EC Number
215-851-5、263-254-3
Nikkaji
J56.130D

Eigenschaften

Berechnete Struktureigenschaften

XLogP
-11,2
Polarare Oberfläche (TPSA)
237 Ų
H-Brücken-Donoren
8
H-Brücken-Akzeptoren
14
Frei drehbare Bindungen
11
Schwere Atome
24

Experimentelle und physikochemische Eigenschaften

Chemical ClassesOther Classes -> Phosphate Compounds
DrugsPharmaceuticals -> Listed in ZINC15
CosmeticsChelating
Physical DescriptionSolid; [Sigma-Aldrich MSDS]

Physikochemische Eigenschaften

Schmelzpunkt
247 °C · 247 °C
Siedepunkt
878.7 · 878.7±75.0 °C(Predicted)
Dichte
1.993 · 1.993±0.06 g/cm3(Predicted)
Dampfdruck
0 Pa · 0Pa at 25℃
storage temp.
-20 °C · Hygroscopic, -20°C Freezer, Under inert atmosphere
Löslichkeit
Aqueous Base (Slightly)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 6 Einträge

Warning

H315 (58.7%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 327 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Gefahrenhinweise

Regulatory Information · 3 Einträge

Chemical: Phosphonic acid, [1,2-ethanediylbis[nitrilobis(methylene)]]tetrakis-

Status: Active Update: 24-10-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23979

Phosphonic acid, [1,2-ethanediylbis[nitrilobis(methylene)]]tetrakis-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazards Summary · 1 Eintrag

Not sensitizing in guinea pigs; No evidence of mutagenicity; Similar phosphonate compounds demonstrate moderate skin and eye irritation and no evidence of teratogenicity; [Reference #1] A skin and strong eye irritant; [Sigma-Aldrich MSDS] See Aminotrimethylene phosphonic acid.

Hazard Classes and Categories · 2 Einträge

Skin Irrit. 2 (58.7%)

Carcinogenicity - Category 1B

Sicherheitsdaten

tsca
TSCA listed
hs_code
29212900
risk_code
36/37/38
hazard_code
Xi
safety_code
26-36/37/39

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological ClassificationChemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.

Verwendung und Herstellung

UsesUsed in consumer dishwashing and laundry detergents; [Reference #1]
Use ClassificationCosmetics -> Chelating
General Manufacturing InformationPhosphonic acid, P,P',P'',P'''-[1,2-ethanediylbis[nitrilobis(methylene)]]tetrakis-: ACTIVE

Anwendungen

VerwendenEthylenediaminetetra(methylenephosphonic acid) is a nitrogenous polyphosphonic acid chelator is able to form complexes with various metal ions.

Vor- und nachgelagerte Produkte

Anbieter50 Anbieter

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
河北创海生物科技有限公司+86-86-13131129325 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]

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