N-2-Aminoethyl-1-naphthylamindihydrochlorid

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.；SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.；INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.；INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. You should then dampen the solid spill material with 60-70% methanol, then transfer the dampened material to a suitable container. Use absorbent paper dampened with methanol to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash contaminated surfaces with 60-70% methanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.；STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=1465-25-4]

N-(1-naphthyl) ethylenediamine dihydrochloride

TR-168: Bioassay of N-(1-Naphthyl)ethylenediamine Dihydrochloride for Possible Carcinogenicity (CASRN 1465-25-4) (1979 )

08/31/78

No Evidence

No Evidence

No Evidence

N-(1-Naphthyl)ethylene Diamine Dihydrochloride was evaluated for the induction of sex-linked recessive lethal mutations in Drosophila melanogaster by the National Toxicology Program. Canton-S wild-type males were treated with concentrations that result in approximately 30% mortality. Following treatment, males were mated individually to 3 harems of Basc virgin females to produce 3 broods for analysis. The concentrations tested by injection (1500 ppm) or feeding (3500 ppm) were negative in this assay.

... Levels of Evidence of Carcinogenicity: Male Rats: Negative; Female Rats: Negative; Male Mice: Negative; Female Mice: Negative.

A bioassay for the possible carcinogenicity of N-(1-naphthyl)ethylenediamine dihydrochloride was conducted using Fischer 344 rats and B6C3F1 mice. N-(1-Naphthyl)ethylenediamine dihydrochloride was administered in the feed, at either of two concn, to groups of 50 male and 50 female animals of each species. Twenty-five rats of each sex and 50 mice of each sex were placed on test as controls. The high and low dietary concentrations of N-(1-naphthyl)ethylenediamine dihydrochloride admin to rats and male mice were 0.1 and 0.05 %, respectively. The high and low time-weighted avg concn admin to female mice were, respectively, 0.3 and 0.2%. The cmpd was admin in the diet for 104 wk, followed by an observation period of 4 wk for high dose rats, 3 wk for low dose rats, low dose female mice, and high dose female mice, and 1 wk for high dose male mice. ... In all groups, except for high dose females, adequate numbers of animals survived sufficiently long to be at risk from late-developing tumors. ... Under the conditions of this bioassay, dietary admin of N-(l-naphthyl)ethylenediamine dihydrochloride was not carcinogenic in Fischer 344 rats or B6C3Fl mice. ... Levels of Evidence of Carcinogenicity: Male Rats: Negative; Female Rats: Negative; Male Mice: Negative; Female Mice: Negative.

Chemical: 1,2-Ethanediamine, N-1-naphthalenyl-, dihydrochloride

1,2-Ethanediamine, N-1-naphthalenyl-, dihydrochloride: Does not have an individual approval but may be used under an appropriate group standard